Everolimus-eluting stent platforms in percutaneous coronary intervention: comparative effectiveness and outcomes

Vasileios F Panoulas,1 Ioannis Mastoris,2 Klio Konstantinou,1 Maurizio Tespili,3 Alfonso Ielasi3 1National Heart and Lung Institute, Imperial College London, London, UK; 2Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A Wiener Cardiovascular Institute, The Icahn Sch...

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Autores principales:	Panoulas VF, Mastoris I, Konstantinou K, Tespili M, Ielasi A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/8b7f165c63a9415a929f8a7c00dfdc9d
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spelling	oai:doaj.org-article:8b7f165c63a9415a929f8a7c00dfdc9d2021-12-02T08:46:06ZEverolimus-eluting stent platforms in percutaneous coronary intervention: comparative effectiveness and outcomes1179-1470https://doaj.org/article/8b7f165c63a9415a929f8a7c00dfdc9d2015-07-01T00:00:00Zhttp://www.dovepress.com/everolimus-eluting-stent-platforms-in-percutaneous-coronary-interventi-peer-reviewed-article-MDERhttps://doaj.org/toc/1179-1470Vasileios F Panoulas,1 Ioannis Mastoris,2 Klio Konstantinou,1 Maurizio Tespili,3 Alfonso Ielasi3 1National Heart and Lung Institute, Imperial College London, London, UK; 2Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A Wiener Cardiovascular Institute, The Icahn School of Medicine at Mount Sinai, New York NY, USA; 3Cardiology Department, Bolognini Hospital Seriate, Seriate (BG), Italy Abstract: Despite the remarkable benefits obtained following the introduction of the first-generation drug-eluting stent (DES), concerns were raised over its long-term safety, particularly with regard to very late (beyond 1 year) stent thrombosis. Newer-generation DESs have been developed to overcome this limitation using novel stent platforms, new drugs, more biocompatible durable polymers, and bioabsorbable polymers or backbones. To date, new-generation DESs have virtually replaced the use of first-generation DESs worldwide. In this review article, we discuss in detail the design, pharmacology, and mechanism of action of the newer-generation permanent and bioresorbable everolimus-eluting platforms. Furthermore, we present and evaluate the current evidence on the performance and safety of these devices compared to those of other available stent platforms. Keywords: PCI, angioplasty, stent, outcome Panoulas VFMastoris IKonstantinou KTespili MIelasi ADove Medical PressarticleMedical technologyR855-855.5ENMedical Devices: Evidence and Research, Vol 2015, Iss default, Pp 317-329 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medical technology R855-855.5
spellingShingle	Medical technology R855-855.5 Panoulas VF Mastoris I Konstantinou K Tespili M Ielasi A Everolimus-eluting stent platforms in percutaneous coronary intervention: comparative effectiveness and outcomes
description	Vasileios F Panoulas,1 Ioannis Mastoris,2 Klio Konstantinou,1 Maurizio Tespili,3 Alfonso Ielasi3 1National Heart and Lung Institute, Imperial College London, London, UK; 2Interventional Cardiovascular Research and Clinical Trials, The Zena and Michael A Wiener Cardiovascular Institute, The Icahn School of Medicine at Mount Sinai, New York NY, USA; 3Cardiology Department, Bolognini Hospital Seriate, Seriate (BG), Italy Abstract: Despite the remarkable benefits obtained following the introduction of the first-generation drug-eluting stent (DES), concerns were raised over its long-term safety, particularly with regard to very late (beyond 1 year) stent thrombosis. Newer-generation DESs have been developed to overcome this limitation using novel stent platforms, new drugs, more biocompatible durable polymers, and bioabsorbable polymers or backbones. To date, new-generation DESs have virtually replaced the use of first-generation DESs worldwide. In this review article, we discuss in detail the design, pharmacology, and mechanism of action of the newer-generation permanent and bioresorbable everolimus-eluting platforms. Furthermore, we present and evaluate the current evidence on the performance and safety of these devices compared to those of other available stent platforms. Keywords: PCI, angioplasty, stent, outcome
format	article
author	Panoulas VF Mastoris I Konstantinou K Tespili M Ielasi A
author_facet	Panoulas VF Mastoris I Konstantinou K Tespili M Ielasi A
author_sort	Panoulas VF
title	Everolimus-eluting stent platforms in percutaneous coronary intervention: comparative effectiveness and outcomes
title_short	Everolimus-eluting stent platforms in percutaneous coronary intervention: comparative effectiveness and outcomes
title_full	Everolimus-eluting stent platforms in percutaneous coronary intervention: comparative effectiveness and outcomes
title_fullStr	Everolimus-eluting stent platforms in percutaneous coronary intervention: comparative effectiveness and outcomes
title_full_unstemmed	Everolimus-eluting stent platforms in percutaneous coronary intervention: comparative effectiveness and outcomes
title_sort	everolimus-eluting stent platforms in percutaneous coronary intervention: comparative effectiveness and outcomes
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/8b7f165c63a9415a929f8a7c00dfdc9d
work_keys_str_mv	AT panoulasvf everolimuselutingstentplatformsinpercutaneouscoronaryinterventioncomparativeeffectivenessandoutcomes AT mastorisi everolimuselutingstentplatformsinpercutaneouscoronaryinterventioncomparativeeffectivenessandoutcomes AT konstantinouk everolimuselutingstentplatformsinpercutaneouscoronaryinterventioncomparativeeffectivenessandoutcomes AT tespilim everolimuselutingstentplatformsinpercutaneouscoronaryinterventioncomparativeeffectivenessandoutcomes AT ielasia everolimuselutingstentplatformsinpercutaneouscoronaryinterventioncomparativeeffectivenessandoutcomes
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Everolimus-eluting stent platforms in percutaneous coronary intervention: comparative effectiveness and outcomes

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