Short communication: selective cytotoxicity of curcumin on osteosarcoma cells compared to healthy osteoblasts

Run Chang,1 Linlin Sun,1 Thomas J Webster1,21Department of Chemical Engineering, Northeastern University, Boston, MA, USA; 2Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah, Saudi ArabiaAbstract: Curcumin is a natural phenolic compound extracted from the plant...

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Autores principales: Chang R, Sun L, Webster TJ
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Lenguaje:EN
Publicado: Dove Medical Press 2014
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Acceso en línea:https://doaj.org/article/8b8191cc7a624eaeb13ada6eaf940930
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spelling oai:doaj.org-article:8b8191cc7a624eaeb13ada6eaf9409302021-12-02T02:06:53ZShort communication: selective cytotoxicity of curcumin on osteosarcoma cells compared to healthy osteoblasts1178-2013https://doaj.org/article/8b8191cc7a624eaeb13ada6eaf9409302014-01-01T00:00:00Zhttp://www.dovepress.com/short-communication-selective-cytotoxicity-of-curcumin-on-osteosarcoma-a15487https://doaj.org/toc/1178-2013 Run Chang,1 Linlin Sun,1 Thomas J Webster1,21Department of Chemical Engineering, Northeastern University, Boston, MA, USA; 2Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah, Saudi ArabiaAbstract: Curcumin is a natural phenolic compound extracted from the plant Curcuma longa L. In previous studies, curcumin has been shown to have anticancer, antioxidant, and anti-inflammatory effects. In this study, the cytotoxicity of different concentrations (5, 10, 25, 50, 75, and 100 µM) of curcumin dissolved in dimethyl sulfoxide was compared between MG-63 osteosarcoma and healthy human osteoblast cells. Consequently, the viability of osteosarcoma cells was less than 50% at a concentration of 10 µM compared to the control sample without curcumin, but healthy osteoblast cells had at least 80% viability throughout all the concentrations tested. The results demonstrated that MG-63 osteosarcoma cells were much more sensitive in terms of cytotoxicity to curcumin, while the healthy human osteoblasts exhibited a higher healthy viability after 24 hours of curcumin treatment. Therefore, this study showed that at the right concentrations (5 µM to 25 µM), curcumin, along with a proper nanoparticle drug delivery carrier, may selectively kill bone cancer cells over healthy bone cells.Keywords: curcumin, osteosarcoma, human osteoblast, viability, bone cancerChang RSun LWebster TJDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 461-465 (2014)
institution DOAJ
collection DOAJ
language EN
topic Medicine (General)
R5-920
spellingShingle Medicine (General)
R5-920
Chang R
Sun L
Webster TJ
Short communication: selective cytotoxicity of curcumin on osteosarcoma cells compared to healthy osteoblasts
description Run Chang,1 Linlin Sun,1 Thomas J Webster1,21Department of Chemical Engineering, Northeastern University, Boston, MA, USA; 2Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah, Saudi ArabiaAbstract: Curcumin is a natural phenolic compound extracted from the plant Curcuma longa L. In previous studies, curcumin has been shown to have anticancer, antioxidant, and anti-inflammatory effects. In this study, the cytotoxicity of different concentrations (5, 10, 25, 50, 75, and 100 µM) of curcumin dissolved in dimethyl sulfoxide was compared between MG-63 osteosarcoma and healthy human osteoblast cells. Consequently, the viability of osteosarcoma cells was less than 50% at a concentration of 10 µM compared to the control sample without curcumin, but healthy osteoblast cells had at least 80% viability throughout all the concentrations tested. The results demonstrated that MG-63 osteosarcoma cells were much more sensitive in terms of cytotoxicity to curcumin, while the healthy human osteoblasts exhibited a higher healthy viability after 24 hours of curcumin treatment. Therefore, this study showed that at the right concentrations (5 µM to 25 µM), curcumin, along with a proper nanoparticle drug delivery carrier, may selectively kill bone cancer cells over healthy bone cells.Keywords: curcumin, osteosarcoma, human osteoblast, viability, bone cancer
format article
author Chang R
Sun L
Webster TJ
author_facet Chang R
Sun L
Webster TJ
author_sort Chang R
title Short communication: selective cytotoxicity of curcumin on osteosarcoma cells compared to healthy osteoblasts
title_short Short communication: selective cytotoxicity of curcumin on osteosarcoma cells compared to healthy osteoblasts
title_full Short communication: selective cytotoxicity of curcumin on osteosarcoma cells compared to healthy osteoblasts
title_fullStr Short communication: selective cytotoxicity of curcumin on osteosarcoma cells compared to healthy osteoblasts
title_full_unstemmed Short communication: selective cytotoxicity of curcumin on osteosarcoma cells compared to healthy osteoblasts
title_sort short communication: selective cytotoxicity of curcumin on osteosarcoma cells compared to healthy osteoblasts
publisher Dove Medical Press
publishDate 2014
url https://doaj.org/article/8b8191cc7a624eaeb13ada6eaf940930
work_keys_str_mv AT changr shortcommunicationselectivecytotoxicityofcurcuminonosteosarcomacellscomparedtohealthyosteoblasts
AT sunl shortcommunicationselectivecytotoxicityofcurcuminonosteosarcomacellscomparedtohealthyosteoblasts
AT webstertj shortcommunicationselectivecytotoxicityofcurcuminonosteosarcomacellscomparedtohealthyosteoblasts
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