Epidermal growth factor gene polymorphism and risk of hepatocellular carcinoma: a meta-analysis.

<h4>Background</h4>Hepatocarcinogenesis is a complex process that may be influenced by many factors, including polymorphism in the epidermal growth factor (EGF) gene. Previous work suggests an association between the EGF 61*A/G polymorphism (rs4444903) and susceptibility to hepatocellula...

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Autores principales:	Jian-Hong Zhong, Xue-Mei You, Wen-Feng Gong, Liang Ma, Yu Zhang, Qin-Guo Mo, Liu-Cheng Wu, Jun Xiao, Le-Qun Li
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8b84eb7052064a2bb619f9e75857f0ee
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spelling	oai:doaj.org-article:8b84eb7052064a2bb619f9e75857f0ee2021-11-18T07:26:10ZEpidermal growth factor gene polymorphism and risk of hepatocellular carcinoma: a meta-analysis.1932-620310.1371/journal.pone.0032159https://doaj.org/article/8b84eb7052064a2bb619f9e75857f0ee2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22403631/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Hepatocarcinogenesis is a complex process that may be influenced by many factors, including polymorphism in the epidermal growth factor (EGF) gene. Previous work suggests an association between the EGF 61A/G polymorphism (rs4444903) and susceptibility to hepatocellular carcinoma (HCC), but the results have been inconsistent. Therefore, we performed a meta-analysis of several studies covering a large population to address this controversy.<h4>Methods</h4>PubMed, EMBASE, Google Scholar and the Chinese National Knowledge Infrastructure databases were systematically searched to identify relevant studies. Data were abstracted independently by two reviewers. A meta-analysis was performed to examine the association between EGF 61A/G polymorphism and susceptibility to HCC. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated.<h4>Results</h4>Eight studies were chosen in this meta-analysis, involving 1,304 HCC cases (1135 Chinese, 44 Caucasian and 125 mixed) and 2,613 controls (1638 Chinese, 77 Caucasian and 898 mixed). The EGF 61G allele was significantly associated with increased risk of HCC based on allelic contrast (OR = 1.29, 95% CI = 1.16-1.44, p<0.001), homozygote comparison (OR = 1.79, 95% CI = 1.39-2.29, p<0.001) and a recessive genetic model (OR = 1.34, 95% CI = 1.16-1.54, p<0.001), while patients carrying the EGF 61A/A genotype had significantly lower risk of HCC than those with the G/A or G/G genotype (A/A vs. G/A+G/G, OR = 0.66, 95% CI = 0.53-0.83, p<0.001).<h4>Conclusion</h4>The 61G polymorphism in EGF is a risk factor for hepatocarcinogenesis while the EGF 61A allele is a protective factor. Further large and well-designed studies are needed to confirm this conclusion.Jian-Hong ZhongXue-Mei YouWen-Feng GongLiang MaYu ZhangQin-Guo MoLiu-Cheng WuJun XiaoLe-Qun LiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 3, p e32159 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jian-Hong Zhong Xue-Mei You Wen-Feng Gong Liang Ma Yu Zhang Qin-Guo Mo Liu-Cheng Wu Jun Xiao Le-Qun Li Epidermal growth factor gene polymorphism and risk of hepatocellular carcinoma: a meta-analysis.
description	<h4>Background</h4>Hepatocarcinogenesis is a complex process that may be influenced by many factors, including polymorphism in the epidermal growth factor (EGF) gene. Previous work suggests an association between the EGF 61A/G polymorphism (rs4444903) and susceptibility to hepatocellular carcinoma (HCC), but the results have been inconsistent. Therefore, we performed a meta-analysis of several studies covering a large population to address this controversy.<h4>Methods</h4>PubMed, EMBASE, Google Scholar and the Chinese National Knowledge Infrastructure databases were systematically searched to identify relevant studies. Data were abstracted independently by two reviewers. A meta-analysis was performed to examine the association between EGF 61A/G polymorphism and susceptibility to HCC. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated.<h4>Results</h4>Eight studies were chosen in this meta-analysis, involving 1,304 HCC cases (1135 Chinese, 44 Caucasian and 125 mixed) and 2,613 controls (1638 Chinese, 77 Caucasian and 898 mixed). The EGF 61G allele was significantly associated with increased risk of HCC based on allelic contrast (OR = 1.29, 95% CI = 1.16-1.44, p<0.001), homozygote comparison (OR = 1.79, 95% CI = 1.39-2.29, p<0.001) and a recessive genetic model (OR = 1.34, 95% CI = 1.16-1.54, p<0.001), while patients carrying the EGF 61A/A genotype had significantly lower risk of HCC than those with the G/A or G/G genotype (A/A vs. G/A+G/G, OR = 0.66, 95% CI = 0.53-0.83, p<0.001).<h4>Conclusion</h4>The 61G polymorphism in EGF is a risk factor for hepatocarcinogenesis while the EGF 61A allele is a protective factor. Further large and well-designed studies are needed to confirm this conclusion.
format	article
author	Jian-Hong Zhong Xue-Mei You Wen-Feng Gong Liang Ma Yu Zhang Qin-Guo Mo Liu-Cheng Wu Jun Xiao Le-Qun Li
author_facet	Jian-Hong Zhong Xue-Mei You Wen-Feng Gong Liang Ma Yu Zhang Qin-Guo Mo Liu-Cheng Wu Jun Xiao Le-Qun Li
author_sort	Jian-Hong Zhong
title	Epidermal growth factor gene polymorphism and risk of hepatocellular carcinoma: a meta-analysis.
title_short	Epidermal growth factor gene polymorphism and risk of hepatocellular carcinoma: a meta-analysis.
title_full	Epidermal growth factor gene polymorphism and risk of hepatocellular carcinoma: a meta-analysis.
title_fullStr	Epidermal growth factor gene polymorphism and risk of hepatocellular carcinoma: a meta-analysis.
title_full_unstemmed	Epidermal growth factor gene polymorphism and risk of hepatocellular carcinoma: a meta-analysis.
title_sort	epidermal growth factor gene polymorphism and risk of hepatocellular carcinoma: a meta-analysis.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/8b84eb7052064a2bb619f9e75857f0ee
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Epidermal growth factor gene polymorphism and risk of hepatocellular carcinoma: a meta-analysis.

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