A systematic review of the effects of psychiatric medications on social cognition

Abstract Introduction Social cognition is an important area of mental functioning relevant to psychiatric disorders and social functioning, that may be affected by psychiatric drug treatments. The aim of this review was to investigate the effects of medications with sedative properties, on social co...

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Autores principales:	Zoë Haime, Andrew J. Watson, Nadia Crellin, Louise Marston, Eileen Joyce, Joanna Moncrieff
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Social cognition Psychopharmacology Schizophrenia Antipsychotic Benzodiazepine Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/8b8528af66ea469d831d693c90b00714
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spelling	oai:doaj.org-article:8b8528af66ea469d831d693c90b007142021-12-05T12:06:09ZA systematic review of the effects of psychiatric medications on social cognition10.1186/s12888-021-03545-z1471-244Xhttps://doaj.org/article/8b8528af66ea469d831d693c90b007142021-11-01T00:00:00Zhttps://doi.org/10.1186/s12888-021-03545-zhttps://doaj.org/toc/1471-244XAbstract Introduction Social cognition is an important area of mental functioning relevant to psychiatric disorders and social functioning, that may be affected by psychiatric drug treatments. The aim of this review was to investigate the effects of medications with sedative properties, on social cognition. Method This systematic review included experimental and neuroimaging studies investigating drug effects on social cognition. Data quality was assessed using a modified Downs and Black checklist (Trac et al. CMAJ 188: E120-E129, 2016). The review used narrative synthesis to analyse the data. Results 40 papers were identified for inclusion, 11 papers investigating benzodiazepine effects, and 29 investigating antipsychotic effects, on social cognition. Narrative synthesis showed that diazepam impairs healthy volunteer’s emotion recognition, with supporting neuroimaging studies showing benzodiazepines attenuate amygdala activity. Studies of antipsychotic effects on social cognition gave variable results. However, many of these studies were in patients already taking medication, and potential practice effects were identified due to short-term follow-ups. Conclusion Healthy volunteer studies suggest that diazepam reduces emotional processing ability. The effects of benzodiazepines on other aspects of social cognition, as well as the effects of antipsychotics, remain unclear. Interpretations of the papers in this review were limited by variability in measures, small sample sizes, and lack of randomisation. More robust studies are necessary to evaluate the impact of these medications on social cognition.Zoë HaimeAndrew J. WatsonNadia CrellinLouise MarstonEileen JoyceJoanna MoncrieffBMCarticleSocial cognitionPsychopharmacologySchizophreniaAntipsychoticBenzodiazepinePsychiatryRC435-571ENBMC Psychiatry, Vol 21, Iss 1, Pp 1-26 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Social cognition Psychopharmacology Schizophrenia Antipsychotic Benzodiazepine Psychiatry RC435-571
spellingShingle	Social cognition Psychopharmacology Schizophrenia Antipsychotic Benzodiazepine Psychiatry RC435-571 Zoë Haime Andrew J. Watson Nadia Crellin Louise Marston Eileen Joyce Joanna Moncrieff A systematic review of the effects of psychiatric medications on social cognition
description	Abstract Introduction Social cognition is an important area of mental functioning relevant to psychiatric disorders and social functioning, that may be affected by psychiatric drug treatments. The aim of this review was to investigate the effects of medications with sedative properties, on social cognition. Method This systematic review included experimental and neuroimaging studies investigating drug effects on social cognition. Data quality was assessed using a modified Downs and Black checklist (Trac et al. CMAJ 188: E120-E129, 2016). The review used narrative synthesis to analyse the data. Results 40 papers were identified for inclusion, 11 papers investigating benzodiazepine effects, and 29 investigating antipsychotic effects, on social cognition. Narrative synthesis showed that diazepam impairs healthy volunteer’s emotion recognition, with supporting neuroimaging studies showing benzodiazepines attenuate amygdala activity. Studies of antipsychotic effects on social cognition gave variable results. However, many of these studies were in patients already taking medication, and potential practice effects were identified due to short-term follow-ups. Conclusion Healthy volunteer studies suggest that diazepam reduces emotional processing ability. The effects of benzodiazepines on other aspects of social cognition, as well as the effects of antipsychotics, remain unclear. Interpretations of the papers in this review were limited by variability in measures, small sample sizes, and lack of randomisation. More robust studies are necessary to evaluate the impact of these medications on social cognition.
format	article
author	Zoë Haime Andrew J. Watson Nadia Crellin Louise Marston Eileen Joyce Joanna Moncrieff
author_facet	Zoë Haime Andrew J. Watson Nadia Crellin Louise Marston Eileen Joyce Joanna Moncrieff
author_sort	Zoë Haime
title	A systematic review of the effects of psychiatric medications on social cognition
title_short	A systematic review of the effects of psychiatric medications on social cognition
title_full	A systematic review of the effects of psychiatric medications on social cognition
title_fullStr	A systematic review of the effects of psychiatric medications on social cognition
title_full_unstemmed	A systematic review of the effects of psychiatric medications on social cognition
title_sort	systematic review of the effects of psychiatric medications on social cognition
publisher	BMC
publishDate	2021
url	https://doaj.org/article/8b8528af66ea469d831d693c90b00714
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A systematic review of the effects of psychiatric medications on social cognition

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