Population Pharmacokinetics and Pharmacodynamics of Praziquantel in Ugandan Children with Intestinal Schistosomiasis: Higher Dosages Are Required for Maximal Efficacy

Population Pharmacokinetics and Pharmacodynamics of Praziquantel in Ugandan Children with Intestinal Schistosomiasis: Higher Dosages Are Required for Maximal Efficacy

ABSTRACT Each year, millions of African children receive praziquantel (PZQ) by mass drug administration (MDA) to treat schistosomiasis at a standard single dose of 40 mg/kg of body weight, a direct extrapolation from studies of adults. A higher dose of 60 mg/kg is also acceptable for refractory case...

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Autores principales: Amaya L. Bustinduy, David Waterhouse, Jose C. de Sousa-Figueiredo, Stephen A. Roberts, Aaron Atuhaire, Govert J. Van Dam, Paul L. A. M. Corstjens, Janet T. Scott, Michelle C. Stanton, Narcis B. Kabatereine, Stephen Ward, William W. Hope, J. Russell Stothard
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2016
Materias:
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/8b891993a4e6486fae10bc9139b1b7b8
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