Four-decade trends in lymph node status of patients with vulvar squamous cell carcinoma in northern Italy

Four-decade trends in lymph node status of patients with vulvar squamous cell carcinoma in northern Italy

Abstract The 4-decade (1980–2017) trends in lymph node status of patients with vulvar squamous cell carcinoma (VSCC) in a province of northern Italy were investigated. Information was collected on lymph node dissection, number of lymph nodes dissected, lymph node involvement, and number of positive...

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Autores principales: Mario Preti, Lauro Bucchi, Leonardo Micheletti, Silvana Privitera, Monica Corazza, Stefano Cosma, Niccolò Gallio, Alessandro Borghi, Federica Bevilacqua, Chiara Benedetto
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Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/8b89c8d73f45406287845e2643dc5f13
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spelling oai:doaj.org-article:8b89c8d73f45406287845e2643dc5f132021-12-02T13:19:29ZFour-decade trends in lymph node status of patients with vulvar squamous cell carcinoma in northern Italy10.1038/s41598-021-85030-x2045-2322https://doaj.org/article/8b89c8d73f45406287845e2643dc5f132021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85030-xhttps://doaj.org/toc/2045-2322Abstract The 4-decade (1980–2017) trends in lymph node status of patients with vulvar squamous cell carcinoma (VSCC) in a province of northern Italy were investigated. Information was collected on lymph node dissection, number of lymph nodes dissected, lymph node involvement, and number of positive lymph nodes from a series of 760 patients admitted to a tertiary referral centre for vulvar disease. The adjusted odds ratios (ORs) for lymph node involvement, for ≥ 2 positive nodes, and for a lymph node ratio ≥ 20% were estimated from multiple logistic regression models. The adjusted OR for lymph node dissection was greater in the 2000s and 2010s versus the 1980s. The adjusted OR for lymph node involvement was 1.36 (95% confidence interval (CI), 0.72–2.60) in the 1990s, 1.31 (95% CI, 0.72–2.38) in the 2000s and 1.32 (95% CI, 0.73–2.41) in the 2010s versus the 1980s. The adjusted OR for ≥ 2 positive nodes was 1.36 (95% CI, 0.68–2.72), 0.86 (95% CI, 0.44–1.65) and 0.67 (95% CI, 0.34–1.31), respectively. The adjusted OR for lymph node ratio ≥ 20% was 1.45 (95% CI, 0.62–3.43), 1.21 (95% CI, 0.54–2.72) and 0.81 (95% CI, 0.35–1.89), respectively. This stagnation indicates the need for a serious rethink of the local model for the care of VSCC.Mario PretiLauro BucchiLeonardo MichelettiSilvana PriviteraMonica CorazzaStefano CosmaNiccolò GallioAlessandro BorghiFederica BevilacquaChiara BenedettoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Mario Preti
Lauro Bucchi
Leonardo Micheletti
Silvana Privitera
Monica Corazza
Stefano Cosma
Niccolò Gallio
Alessandro Borghi
Federica Bevilacqua
Chiara Benedetto
Four-decade trends in lymph node status of patients with vulvar squamous cell carcinoma in northern Italy
description Abstract The 4-decade (1980–2017) trends in lymph node status of patients with vulvar squamous cell carcinoma (VSCC) in a province of northern Italy were investigated. Information was collected on lymph node dissection, number of lymph nodes dissected, lymph node involvement, and number of positive lymph nodes from a series of 760 patients admitted to a tertiary referral centre for vulvar disease. The adjusted odds ratios (ORs) for lymph node involvement, for ≥ 2 positive nodes, and for a lymph node ratio ≥ 20% were estimated from multiple logistic regression models. The adjusted OR for lymph node dissection was greater in the 2000s and 2010s versus the 1980s. The adjusted OR for lymph node involvement was 1.36 (95% confidence interval (CI), 0.72–2.60) in the 1990s, 1.31 (95% CI, 0.72–2.38) in the 2000s and 1.32 (95% CI, 0.73–2.41) in the 2010s versus the 1980s. The adjusted OR for ≥ 2 positive nodes was 1.36 (95% CI, 0.68–2.72), 0.86 (95% CI, 0.44–1.65) and 0.67 (95% CI, 0.34–1.31), respectively. The adjusted OR for lymph node ratio ≥ 20% was 1.45 (95% CI, 0.62–3.43), 1.21 (95% CI, 0.54–2.72) and 0.81 (95% CI, 0.35–1.89), respectively. This stagnation indicates the need for a serious rethink of the local model for the care of VSCC.
format article
author Mario Preti
Lauro Bucchi
Leonardo Micheletti
Silvana Privitera
Monica Corazza
Stefano Cosma
Niccolò Gallio
Alessandro Borghi
Federica Bevilacqua
Chiara Benedetto
author_facet Mario Preti
Lauro Bucchi
Leonardo Micheletti
Silvana Privitera
Monica Corazza
Stefano Cosma
Niccolò Gallio
Alessandro Borghi
Federica Bevilacqua
Chiara Benedetto
author_sort Mario Preti
title Four-decade trends in lymph node status of patients with vulvar squamous cell carcinoma in northern Italy
title_short Four-decade trends in lymph node status of patients with vulvar squamous cell carcinoma in northern Italy
title_full Four-decade trends in lymph node status of patients with vulvar squamous cell carcinoma in northern Italy
title_fullStr Four-decade trends in lymph node status of patients with vulvar squamous cell carcinoma in northern Italy
title_full_unstemmed Four-decade trends in lymph node status of patients with vulvar squamous cell carcinoma in northern Italy
title_sort four-decade trends in lymph node status of patients with vulvar squamous cell carcinoma in northern italy
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/8b89c8d73f45406287845e2643dc5f13
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