Targeting myelin lipid metabolism as a potential therapeutic strategy in a model of CMT1A neuropathy

Targeting myelin lipid metabolism as a potential therapeutic strategy in a model of CMT1A neuropathy

Charcot–Marie–Tooth disease 1A (CMT1A) is a peripheral demyelinating disease. Here, the authors demonstrate in a rodent model of CMT1A that Schwann cells have impairments in lipid biosynthesis, and that restoring lipids via diet can reverse the dysmyelinating phenotype in these animals.

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Autores principales: R. Fledrich, T. Abdelaal, L. Rasch, V. Bansal, V. Schütza, B. Brügger, C. Lüchtenborg, T. Prukop, J. Stenzel, R. U. Rahman, D. Hermes, D. Ewers, W. Möbius, T. Ruhwedel, I. Katona, J. Weis, D. Klein, R. Martini, W. Brück, W. C. Müller, S. Bonn, I. Bechmann, K. A. Nave, R. M. Stassart, M. W. Sereda
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/8b8e4e83c023447f9c6cbe01a5ec8a8b
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spelling oai:doaj.org-article:8b8e4e83c023447f9c6cbe01a5ec8a8b2021-12-02T17:31:59ZTargeting myelin lipid metabolism as a potential therapeutic strategy in a model of CMT1A neuropathy10.1038/s41467-018-05420-02041-1723https://doaj.org/article/8b8e4e83c023447f9c6cbe01a5ec8a8b2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05420-0https://doaj.org/toc/2041-1723Charcot–Marie–Tooth disease 1A (CMT1A) is a peripheral demyelinating disease. Here, the authors demonstrate in a rodent model of CMT1A that Schwann cells have impairments in lipid biosynthesis, and that restoring lipids via diet can reverse the dysmyelinating phenotype in these animals.R. FledrichT. AbdelaalL. RaschV. BansalV. SchützaB. BrüggerC. LüchtenborgT. PrukopJ. StenzelR. U. RahmanD. HermesD. EwersW. MöbiusT. RuhwedelI. KatonaJ. WeisD. KleinR. MartiniW. BrückW. C. MüllerS. BonnI. BechmannK. A. NaveR. M. StassartM. W. SeredaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
R. Fledrich
T. Abdelaal
L. Rasch
V. Bansal
V. Schütza
B. Brügger
C. Lüchtenborg
T. Prukop
J. Stenzel
R. U. Rahman
D. Hermes
D. Ewers
W. Möbius
T. Ruhwedel
I. Katona
J. Weis
D. Klein
R. Martini
W. Brück
W. C. Müller
S. Bonn
I. Bechmann
K. A. Nave
R. M. Stassart
M. W. Sereda
Targeting myelin lipid metabolism as a potential therapeutic strategy in a model of CMT1A neuropathy
description Charcot–Marie–Tooth disease 1A (CMT1A) is a peripheral demyelinating disease. Here, the authors demonstrate in a rodent model of CMT1A that Schwann cells have impairments in lipid biosynthesis, and that restoring lipids via diet can reverse the dysmyelinating phenotype in these animals.
format article
author R. Fledrich
T. Abdelaal
L. Rasch
V. Bansal
V. Schütza
B. Brügger
C. Lüchtenborg
T. Prukop
J. Stenzel
R. U. Rahman
D. Hermes
D. Ewers
W. Möbius
T. Ruhwedel
I. Katona
J. Weis
D. Klein
R. Martini
W. Brück
W. C. Müller
S. Bonn
I. Bechmann
K. A. Nave
R. M. Stassart
M. W. Sereda
author_facet R. Fledrich
T. Abdelaal
L. Rasch
V. Bansal
V. Schütza
B. Brügger
C. Lüchtenborg
T. Prukop
J. Stenzel
R. U. Rahman
D. Hermes
D. Ewers
W. Möbius
T. Ruhwedel
I. Katona
J. Weis
D. Klein
R. Martini
W. Brück
W. C. Müller
S. Bonn
I. Bechmann
K. A. Nave
R. M. Stassart
M. W. Sereda
author_sort R. Fledrich
title Targeting myelin lipid metabolism as a potential therapeutic strategy in a model of CMT1A neuropathy
title_short Targeting myelin lipid metabolism as a potential therapeutic strategy in a model of CMT1A neuropathy
title_full Targeting myelin lipid metabolism as a potential therapeutic strategy in a model of CMT1A neuropathy
title_fullStr Targeting myelin lipid metabolism as a potential therapeutic strategy in a model of CMT1A neuropathy
title_full_unstemmed Targeting myelin lipid metabolism as a potential therapeutic strategy in a model of CMT1A neuropathy
title_sort targeting myelin lipid metabolism as a potential therapeutic strategy in a model of cmt1a neuropathy
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/8b8e4e83c023447f9c6cbe01a5ec8a8b
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