The mitral regurgitation effects of cardiac structure and function in left ventricular noncompaction

Abstract This study evaluated the effects of mitral regurgitation (MR) on cardiac structure and function in left ventricular noncompaction (LVNC) patients. The clinical and cardiovascular magnetic resonance (CMR) data for 182 patients with noncompaction or hypertrabeculation from three institutes we...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Qing Zou, Rong Xu, Xiao Li, Hua-yan Xu, Zhi-gang Yang, Yi-ning Wang, Hai-ming Fan, Ying-kun Guo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8b8fb6ba91c242e0be29091e755280c9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8b8fb6ba91c242e0be29091e755280c9
record_format	dspace
spelling	oai:doaj.org-article:8b8fb6ba91c242e0be29091e755280c92021-12-02T13:20:01ZThe mitral regurgitation effects of cardiac structure and function in left ventricular noncompaction10.1038/s41598-021-84233-62045-2322https://doaj.org/article/8b8fb6ba91c242e0be29091e755280c92021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84233-6https://doaj.org/toc/2045-2322Abstract This study evaluated the effects of mitral regurgitation (MR) on cardiac structure and function in left ventricular noncompaction (LVNC) patients. The clinical and cardiovascular magnetic resonance (CMR) data for 182 patients with noncompaction or hypertrabeculation from three institutes were retrospectively included. We analyzed the difference in left ventricular geometry, cardiac function between LVNC patients with and without MR. The results showed that patients with MR had a worse New York Heart Association (NYHA) class and a higher incidence of arrhythmia (P < 0.05). MR occurred in 48.2% of LVNC patients. Compared to LVNC patients without MR, the two-dimensional sphericity index, maximum/minimum end-diastolic ratio and longitudinal shortening in LVNC patients with MR were lower (P < 0.05), and the peak longitudinal strain (PLS) of the global and segmental myocardium were obviously reduced (P < 0.05). No significant difference was found in strain in LVNC patients with different degree of MR; end diastolic volume, end systolic volume, and global PLS were statistically associated with MR and NYHA class (P < 0.05), but the non-compacted to compacted myocardium ratio had no significant correlation with them. In conclusion, the presence of MR is common in LVNC patients. LVNC patients with MR feature more severe morphological and functional changes. Hypertrabeculation is not an important factor affecting structure and function at the heart failure stage.Qing ZouRong XuXiao LiHua-yan XuZhi-gang YangYi-ning WangHai-ming FanYing-kun GuoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Qing Zou Rong Xu Xiao Li Hua-yan Xu Zhi-gang Yang Yi-ning Wang Hai-ming Fan Ying-kun Guo The mitral regurgitation effects of cardiac structure and function in left ventricular noncompaction
description	Abstract This study evaluated the effects of mitral regurgitation (MR) on cardiac structure and function in left ventricular noncompaction (LVNC) patients. The clinical and cardiovascular magnetic resonance (CMR) data for 182 patients with noncompaction or hypertrabeculation from three institutes were retrospectively included. We analyzed the difference in left ventricular geometry, cardiac function between LVNC patients with and without MR. The results showed that patients with MR had a worse New York Heart Association (NYHA) class and a higher incidence of arrhythmia (P < 0.05). MR occurred in 48.2% of LVNC patients. Compared to LVNC patients without MR, the two-dimensional sphericity index, maximum/minimum end-diastolic ratio and longitudinal shortening in LVNC patients with MR were lower (P < 0.05), and the peak longitudinal strain (PLS) of the global and segmental myocardium were obviously reduced (P < 0.05). No significant difference was found in strain in LVNC patients with different degree of MR; end diastolic volume, end systolic volume, and global PLS were statistically associated with MR and NYHA class (P < 0.05), but the non-compacted to compacted myocardium ratio had no significant correlation with them. In conclusion, the presence of MR is common in LVNC patients. LVNC patients with MR feature more severe morphological and functional changes. Hypertrabeculation is not an important factor affecting structure and function at the heart failure stage.
format	article
author	Qing Zou Rong Xu Xiao Li Hua-yan Xu Zhi-gang Yang Yi-ning Wang Hai-ming Fan Ying-kun Guo
author_facet	Qing Zou Rong Xu Xiao Li Hua-yan Xu Zhi-gang Yang Yi-ning Wang Hai-ming Fan Ying-kun Guo
author_sort	Qing Zou
title	The mitral regurgitation effects of cardiac structure and function in left ventricular noncompaction
title_short	The mitral regurgitation effects of cardiac structure and function in left ventricular noncompaction
title_full	The mitral regurgitation effects of cardiac structure and function in left ventricular noncompaction
title_fullStr	The mitral regurgitation effects of cardiac structure and function in left ventricular noncompaction
title_full_unstemmed	The mitral regurgitation effects of cardiac structure and function in left ventricular noncompaction
title_sort	mitral regurgitation effects of cardiac structure and function in left ventricular noncompaction
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8b8fb6ba91c242e0be29091e755280c9
work_keys_str_mv	AT qingzou themitralregurgitationeffectsofcardiacstructureandfunctioninleftventricularnoncompaction AT rongxu themitralregurgitationeffectsofcardiacstructureandfunctioninleftventricularnoncompaction AT xiaoli themitralregurgitationeffectsofcardiacstructureandfunctioninleftventricularnoncompaction AT huayanxu themitralregurgitationeffectsofcardiacstructureandfunctioninleftventricularnoncompaction AT zhigangyang themitralregurgitationeffectsofcardiacstructureandfunctioninleftventricularnoncompaction AT yiningwang themitralregurgitationeffectsofcardiacstructureandfunctioninleftventricularnoncompaction AT haimingfan themitralregurgitationeffectsofcardiacstructureandfunctioninleftventricularnoncompaction AT yingkunguo themitralregurgitationeffectsofcardiacstructureandfunctioninleftventricularnoncompaction AT qingzou mitralregurgitationeffectsofcardiacstructureandfunctioninleftventricularnoncompaction AT rongxu mitralregurgitationeffectsofcardiacstructureandfunctioninleftventricularnoncompaction AT xiaoli mitralregurgitationeffectsofcardiacstructureandfunctioninleftventricularnoncompaction AT huayanxu mitralregurgitationeffectsofcardiacstructureandfunctioninleftventricularnoncompaction AT zhigangyang mitralregurgitationeffectsofcardiacstructureandfunctioninleftventricularnoncompaction AT yiningwang mitralregurgitationeffectsofcardiacstructureandfunctioninleftventricularnoncompaction AT haimingfan mitralregurgitationeffectsofcardiacstructureandfunctioninleftventricularnoncompaction AT yingkunguo mitralregurgitationeffectsofcardiacstructureandfunctioninleftventricularnoncompaction
_version_	1718393286364758016

The mitral regurgitation effects of cardiac structure and function in left ventricular noncompaction

Ejemplares similares