Silencing of miR-34a attenuates cardiac dysfunction in a setting of moderate, but not severe, hypertrophic cardiomyopathy.

Silencing of miR-34a attenuates cardiac dysfunction in a setting of moderate, but not severe, hypertrophic cardiomyopathy.

Therapeutic inhibition of the miR-34 family (miR-34a,-b,-c), or miR-34a alone, have emerged as promising strategies for the treatment of cardiac pathology. However, before advancing these approaches further for potential entry into the clinic, a more comprehensive assessment of the therapeutic poten...

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Main Authors: Bianca C Bernardo, Xiao-Ming Gao, Yow Keat Tham, Helen Kiriazis, Catherine E Winbanks, Jenny Y Y Ooi, Esther J H Boey, Susanna Obad, Sakari Kauppinen, Paul Gregorevic, Xiao-Jun Du, Ruby C Y Lin, Julie R McMullen
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2014
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/8b902a46757b434fbe7761cf030d6d9f
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https://doaj.org/article/8b902a46757b434fbe7761cf030d6d9f

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