A genome-scale Escherichia coli kinetic metabolic model k-ecoli457 satisfying flux data for multiple mutant strains

Kinetic models of microbial metabolism have great potential to aid metabolic engineering efforts, but the challenge of parameterization has so far limited them to core metabolism. Here, the authors introduce a genome-scale metabolic model of E. colimetabolism that satisfies fluxomic data for a wild-...

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Autores principales:	Ali Khodayari, Costas D. Maranas
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8b90818b6a3044cb9a639e1583c12d45
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spelling	oai:doaj.org-article:8b90818b6a3044cb9a639e1583c12d452021-12-02T15:35:41ZA genome-scale Escherichia coli kinetic metabolic model k-ecoli457 satisfying flux data for multiple mutant strains10.1038/ncomms138062041-1723https://doaj.org/article/8b90818b6a3044cb9a639e1583c12d452016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13806https://doaj.org/toc/2041-1723Kinetic models of microbial metabolism have great potential to aid metabolic engineering efforts, but the challenge of parameterization has so far limited them to core metabolism. Here, the authors introduce a genome-scale metabolic model of E. colimetabolism that satisfies fluxomic data for a wild-type and 25 mutant strains in various growth conditions.Ali KhodayariCostas D. MaranasNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ali Khodayari Costas D. Maranas A genome-scale Escherichia coli kinetic metabolic model k-ecoli457 satisfying flux data for multiple mutant strains
description	Kinetic models of microbial metabolism have great potential to aid metabolic engineering efforts, but the challenge of parameterization has so far limited them to core metabolism. Here, the authors introduce a genome-scale metabolic model of E. colimetabolism that satisfies fluxomic data for a wild-type and 25 mutant strains in various growth conditions.
format	article
author	Ali Khodayari Costas D. Maranas
author_facet	Ali Khodayari Costas D. Maranas
author_sort	Ali Khodayari
title	A genome-scale Escherichia coli kinetic metabolic model k-ecoli457 satisfying flux data for multiple mutant strains
title_short	A genome-scale Escherichia coli kinetic metabolic model k-ecoli457 satisfying flux data for multiple mutant strains
title_full	A genome-scale Escherichia coli kinetic metabolic model k-ecoli457 satisfying flux data for multiple mutant strains
title_fullStr	A genome-scale Escherichia coli kinetic metabolic model k-ecoli457 satisfying flux data for multiple mutant strains
title_full_unstemmed	A genome-scale Escherichia coli kinetic metabolic model k-ecoli457 satisfying flux data for multiple mutant strains
title_sort	genome-scale escherichia coli kinetic metabolic model k-ecoli457 satisfying flux data for multiple mutant strains
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/8b90818b6a3044cb9a639e1583c12d45
work_keys_str_mv	AT alikhodayari agenomescaleescherichiacolikineticmetabolicmodelkecoli457satisfyingfluxdataformultiplemutantstrains AT costasdmaranas agenomescaleescherichiacolikineticmetabolicmodelkecoli457satisfyingfluxdataformultiplemutantstrains AT alikhodayari genomescaleescherichiacolikineticmetabolicmodelkecoli457satisfyingfluxdataformultiplemutantstrains AT costasdmaranas genomescaleescherichiacolikineticmetabolicmodelkecoli457satisfyingfluxdataformultiplemutantstrains
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A genome-scale Escherichia coli kinetic metabolic model k-ecoli457 satisfying flux data for multiple mutant strains

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