The effect of hydroalcoholic extract of Melissa Officinalis in prevention of convulsions induced by Nicotine in mice

Background and Objective: Hydroalcoholic extract of Melissa Officinalis (MO) has been considered as an anticonvulsant in traditional medicine. This study was done to determine its effect in prevention of convulsions induced by nicotine in mice. Methods: Normal saline (10 ml/kg) was injected to contr...

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Autores principales:	A Arzi, M Shafie
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2002
Materias:	melissa officinalis convulsions nicotine Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8b95e226e84d487ea21fbe42361ec33c
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spelling	oai:doaj.org-article:8b95e226e84d487ea21fbe42361ec33c2021-11-10T09:19:31ZThe effect of hydroalcoholic extract of Melissa Officinalis in prevention of convulsions induced by Nicotine in mice1561-41072251-7170https://doaj.org/article/8b95e226e84d487ea21fbe42361ec33c2002-04-01T00:00:00Zhttp://jbums.org/article-1-2829-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170Background and Objective: Hydroalcoholic extract of Melissa Officinalis (MO) has been considered as an anticonvulsant in traditional medicine. This study was done to determine its effect in prevention of convulsions induced by nicotine in mice. Methods: Normal saline (10 ml/kg) was injected to control group (i.p). After preparation of hydroalcoholic extract of MO by maceration method, doses of 200, 400, 600, 800 and 1000 mg/kg of this extract administered separately at 0, 15, 30 and 45 minutes before injection of nicotine. Then intensity, duration and latency of convulsions and mortality rate were surveyed. Findings: Administration of the extract with doses of 800 and 1000 mg/kg at 15, 30 and 45 minutes and with dose of 600 mg/kg at 30 min before injection of nicotine significantly increased the latency of convulsions (P<0.05). None of administered doses changed the intensity of convulsions significantly. Conclusion: Obtained results showed that hydroalcoholic extract of Melissa Officinalis (MO) cause to increase latency and intensity of convulsions induced by Nicotine.A ArziM ShafieBabol University of Medical Sciencesarticlemelissa officinalisconvulsionsnicotineMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 4, Iss 2, Pp 18-22 (2002)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	melissa officinalis convulsions nicotine Medicine R Medicine (General) R5-920
spellingShingle	melissa officinalis convulsions nicotine Medicine R Medicine (General) R5-920 A Arzi M Shafie The effect of hydroalcoholic extract of Melissa Officinalis in prevention of convulsions induced by Nicotine in mice
description	Background and Objective: Hydroalcoholic extract of Melissa Officinalis (MO) has been considered as an anticonvulsant in traditional medicine. This study was done to determine its effect in prevention of convulsions induced by nicotine in mice. Methods: Normal saline (10 ml/kg) was injected to control group (i.p). After preparation of hydroalcoholic extract of MO by maceration method, doses of 200, 400, 600, 800 and 1000 mg/kg of this extract administered separately at 0, 15, 30 and 45 minutes before injection of nicotine. Then intensity, duration and latency of convulsions and mortality rate were surveyed. Findings: Administration of the extract with doses of 800 and 1000 mg/kg at 15, 30 and 45 minutes and with dose of 600 mg/kg at 30 min before injection of nicotine significantly increased the latency of convulsions (P<0.05). None of administered doses changed the intensity of convulsions significantly. Conclusion: Obtained results showed that hydroalcoholic extract of Melissa Officinalis (MO) cause to increase latency and intensity of convulsions induced by Nicotine.
format	article
author	A Arzi M Shafie
author_facet	A Arzi M Shafie
author_sort	A Arzi
title	The effect of hydroalcoholic extract of Melissa Officinalis in prevention of convulsions induced by Nicotine in mice
title_short	The effect of hydroalcoholic extract of Melissa Officinalis in prevention of convulsions induced by Nicotine in mice
title_full	The effect of hydroalcoholic extract of Melissa Officinalis in prevention of convulsions induced by Nicotine in mice
title_fullStr	The effect of hydroalcoholic extract of Melissa Officinalis in prevention of convulsions induced by Nicotine in mice
title_full_unstemmed	The effect of hydroalcoholic extract of Melissa Officinalis in prevention of convulsions induced by Nicotine in mice
title_sort	effect of hydroalcoholic extract of melissa officinalis in prevention of convulsions induced by nicotine in mice
publisher	Babol University of Medical Sciences
publishDate	2002
url	https://doaj.org/article/8b95e226e84d487ea21fbe42361ec33c
work_keys_str_mv	AT aarzi theeffectofhydroalcoholicextractofmelissaofficinalisinpreventionofconvulsionsinducedbynicotineinmice AT mshafie theeffectofhydroalcoholicextractofmelissaofficinalisinpreventionofconvulsionsinducedbynicotineinmice AT aarzi effectofhydroalcoholicextractofmelissaofficinalisinpreventionofconvulsionsinducedbynicotineinmice AT mshafie effectofhydroalcoholicextractofmelissaofficinalisinpreventionofconvulsionsinducedbynicotineinmice
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The effect of hydroalcoholic extract of Melissa Officinalis in prevention of convulsions induced by Nicotine in mice

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