Resveratrol increases glucose induced GLP-1 secretion in mice: a mechanism which contributes to the glycemic control.
Resveratrol (RSV) is a potent anti-diabetic agent when used at high doses. However, the direct targets primarily responsible for the beneficial actions of RSV remain unclear. We used a formulation that increases oral bioavailability to assess the mechanisms involved in the glucoregulatory action of...
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2011
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oai:doaj.org-article:8b96eb10e8834befa95800ee2058fc4c2021-11-18T06:52:35ZResveratrol increases glucose induced GLP-1 secretion in mice: a mechanism which contributes to the glycemic control.1932-620310.1371/journal.pone.0020700https://doaj.org/article/8b96eb10e8834befa95800ee2058fc4c2011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21673955/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Resveratrol (RSV) is a potent anti-diabetic agent when used at high doses. However, the direct targets primarily responsible for the beneficial actions of RSV remain unclear. We used a formulation that increases oral bioavailability to assess the mechanisms involved in the glucoregulatory action of RSV in high-fat diet (HFD)-fed diabetic wild type mice. Administration of RSV for 5 weeks reduced the development of glucose intolerance, and increased portal vein concentrations of both Glucagon-like peptid-1 (GLP-1) and insulin, and intestinal content of active GLP-1. This was associated with increased levels of colonic proglucagon mRNA transcripts. RSV-mediated glucoregulation required a functional GLP-1 receptor (Glp1r) as neither glucose nor insulin levels were modulated in Glp1r-/- mice. Conversely, levels of active GLP-1 and control of glycemia were further improved when the Dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin was co-administered with RSV. In addition, RSV treatment modified gut microbiota and decreased the inflammatory status of mice. Our data suggest that RSV exerts its actions in part through modulation of the enteroendocrine axis in vivo.Thi-Mai Anh DaoAurélie WagetPascale KloppMatteo SerinoChristelle VachouxLaurent PechereDaniel J DruckerSerge ChampionSylvain BarthélemyYves BarraRémy BurcelinEric SéréePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 6, p e20700 (2011) |
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Medicine R Science Q |
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Medicine R Science Q Thi-Mai Anh Dao Aurélie Waget Pascale Klopp Matteo Serino Christelle Vachoux Laurent Pechere Daniel J Drucker Serge Champion Sylvain Barthélemy Yves Barra Rémy Burcelin Eric Sérée Resveratrol increases glucose induced GLP-1 secretion in mice: a mechanism which contributes to the glycemic control. |
| description |
Resveratrol (RSV) is a potent anti-diabetic agent when used at high doses. However, the direct targets primarily responsible for the beneficial actions of RSV remain unclear. We used a formulation that increases oral bioavailability to assess the mechanisms involved in the glucoregulatory action of RSV in high-fat diet (HFD)-fed diabetic wild type mice. Administration of RSV for 5 weeks reduced the development of glucose intolerance, and increased portal vein concentrations of both Glucagon-like peptid-1 (GLP-1) and insulin, and intestinal content of active GLP-1. This was associated with increased levels of colonic proglucagon mRNA transcripts. RSV-mediated glucoregulation required a functional GLP-1 receptor (Glp1r) as neither glucose nor insulin levels were modulated in Glp1r-/- mice. Conversely, levels of active GLP-1 and control of glycemia were further improved when the Dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin was co-administered with RSV. In addition, RSV treatment modified gut microbiota and decreased the inflammatory status of mice. Our data suggest that RSV exerts its actions in part through modulation of the enteroendocrine axis in vivo. |
| format |
article |
| author |
Thi-Mai Anh Dao Aurélie Waget Pascale Klopp Matteo Serino Christelle Vachoux Laurent Pechere Daniel J Drucker Serge Champion Sylvain Barthélemy Yves Barra Rémy Burcelin Eric Sérée |
| author_facet |
Thi-Mai Anh Dao Aurélie Waget Pascale Klopp Matteo Serino Christelle Vachoux Laurent Pechere Daniel J Drucker Serge Champion Sylvain Barthélemy Yves Barra Rémy Burcelin Eric Sérée |
| author_sort |
Thi-Mai Anh Dao |
| title |
Resveratrol increases glucose induced GLP-1 secretion in mice: a mechanism which contributes to the glycemic control. |
| title_short |
Resveratrol increases glucose induced GLP-1 secretion in mice: a mechanism which contributes to the glycemic control. |
| title_full |
Resveratrol increases glucose induced GLP-1 secretion in mice: a mechanism which contributes to the glycemic control. |
| title_fullStr |
Resveratrol increases glucose induced GLP-1 secretion in mice: a mechanism which contributes to the glycemic control. |
| title_full_unstemmed |
Resveratrol increases glucose induced GLP-1 secretion in mice: a mechanism which contributes to the glycemic control. |
| title_sort |
resveratrol increases glucose induced glp-1 secretion in mice: a mechanism which contributes to the glycemic control. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2011 |
| url |
https://doaj.org/article/8b96eb10e8834befa95800ee2058fc4c |
| work_keys_str_mv |
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