DCBLD1 is associated with the integrin signaling pathway and has prognostic value in non-small cell lung and invasive breast carcinoma

Abstract Germline single nucleotide polymorphisms in the promoter region of the DCBLD1 gene are associated with non-smoking cases of both non-small cell lung carcinoma (NSCLC) and human papillomavirus-negative head and neck cancer. However the clinical relevance and function of DCBLD1 remain unclear...

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Autores principales:	Guillaume B. Cardin, Monique Bernard, Francis Rodier, Apostolos Christopoulos
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8ba00709e590431b8952cc5729226de6
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spelling	oai:doaj.org-article:8ba00709e590431b8952cc5729226de62021-12-02T16:04:23ZDCBLD1 is associated with the integrin signaling pathway and has prognostic value in non-small cell lung and invasive breast carcinoma10.1038/s41598-021-92090-62045-2322https://doaj.org/article/8ba00709e590431b8952cc5729226de62021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92090-6https://doaj.org/toc/2045-2322Abstract Germline single nucleotide polymorphisms in the promoter region of the DCBLD1 gene are associated with non-smoking cases of both non-small cell lung carcinoma (NSCLC) and human papillomavirus-negative head and neck cancer. However the clinical relevance and function of DCBLD1 remain unclear. This multicenter retrospective study was designed to evaluate the prognostic value and function of DCBLD1 in the four main solid cancers: NSCLC, invasive breast carcinoma, colorectal adenocarcinoma and prostate adenocarcinoma. We included the following cohorts: GSE81089 NSCLC, METABRIC invasive breast carcinoma, GSE14333 colorectal adenocarcinoma, GSE70770 prostate adenocarcinoma and The Cancer Genome Atlas (TCGA) Firehose Legacy cohorts of all four cancers. DCBLD1 gene expression was associated with a worse overall survival in multivariate analyses for both NSCLC cohorts (TCGA: P = 0.03 and GSE81089: P = 0.04) and both invasive breast carcinoma cohorts (TCGA: P = 0.02 and METABRIC: P < 0.001). Patients with high DCBLD1 expression showed an upregulation of the integrin signaling pathway in comparison to those with low DCBLD1 expression in the TCGA NSCLC cohort (FDR = 5.16 × 10–14) and TCGA invasive breast carcinoma cohort (FDR = 1.94 × 10–05).Guillaume B. CardinMonique BernardFrancis RodierApostolos ChristopoulosNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Guillaume B. Cardin Monique Bernard Francis Rodier Apostolos Christopoulos DCBLD1 is associated with the integrin signaling pathway and has prognostic value in non-small cell lung and invasive breast carcinoma
description	Abstract Germline single nucleotide polymorphisms in the promoter region of the DCBLD1 gene are associated with non-smoking cases of both non-small cell lung carcinoma (NSCLC) and human papillomavirus-negative head and neck cancer. However the clinical relevance and function of DCBLD1 remain unclear. This multicenter retrospective study was designed to evaluate the prognostic value and function of DCBLD1 in the four main solid cancers: NSCLC, invasive breast carcinoma, colorectal adenocarcinoma and prostate adenocarcinoma. We included the following cohorts: GSE81089 NSCLC, METABRIC invasive breast carcinoma, GSE14333 colorectal adenocarcinoma, GSE70770 prostate adenocarcinoma and The Cancer Genome Atlas (TCGA) Firehose Legacy cohorts of all four cancers. DCBLD1 gene expression was associated with a worse overall survival in multivariate analyses for both NSCLC cohorts (TCGA: P = 0.03 and GSE81089: P = 0.04) and both invasive breast carcinoma cohorts (TCGA: P = 0.02 and METABRIC: P < 0.001). Patients with high DCBLD1 expression showed an upregulation of the integrin signaling pathway in comparison to those with low DCBLD1 expression in the TCGA NSCLC cohort (FDR = 5.16 × 10–14) and TCGA invasive breast carcinoma cohort (FDR = 1.94 × 10–05).
format	article
author	Guillaume B. Cardin Monique Bernard Francis Rodier Apostolos Christopoulos
author_facet	Guillaume B. Cardin Monique Bernard Francis Rodier Apostolos Christopoulos
author_sort	Guillaume B. Cardin
title	DCBLD1 is associated with the integrin signaling pathway and has prognostic value in non-small cell lung and invasive breast carcinoma
title_short	DCBLD1 is associated with the integrin signaling pathway and has prognostic value in non-small cell lung and invasive breast carcinoma
title_full	DCBLD1 is associated with the integrin signaling pathway and has prognostic value in non-small cell lung and invasive breast carcinoma
title_fullStr	DCBLD1 is associated with the integrin signaling pathway and has prognostic value in non-small cell lung and invasive breast carcinoma
title_full_unstemmed	DCBLD1 is associated with the integrin signaling pathway and has prognostic value in non-small cell lung and invasive breast carcinoma
title_sort	dcbld1 is associated with the integrin signaling pathway and has prognostic value in non-small cell lung and invasive breast carcinoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8ba00709e590431b8952cc5729226de6
work_keys_str_mv	AT guillaumebcardin dcbld1isassociatedwiththeintegrinsignalingpathwayandhasprognosticvalueinnonsmallcelllungandinvasivebreastcarcinoma AT moniquebernard dcbld1isassociatedwiththeintegrinsignalingpathwayandhasprognosticvalueinnonsmallcelllungandinvasivebreastcarcinoma AT francisrodier dcbld1isassociatedwiththeintegrinsignalingpathwayandhasprognosticvalueinnonsmallcelllungandinvasivebreastcarcinoma AT apostoloschristopoulos dcbld1isassociatedwiththeintegrinsignalingpathwayandhasprognosticvalueinnonsmallcelllungandinvasivebreastcarcinoma
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DCBLD1 is associated with the integrin signaling pathway and has prognostic value in non-small cell lung and invasive breast carcinoma

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