Multiple Functions of Draxin/Netrin-1 Signaling in the Development of Neural Circuits in the Spinal Cord and the Brain

Axon guidance proteins play key roles in the formation of neural circuits during development. We previously identified an axon guidance cue, named draxin, that has no homology with other axon guidance proteins. Draxin is essential for the development of various neural circuits including the spinal c...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Giasuddin Ahmed, Yohei Shinmyo
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	axon guidance draxin netrin-1 spinal commissural axons corpus callosum thalamocortical projections Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Human anatomy QM1-695
Acceso en línea:	https://doaj.org/article/8ba0fd7f08a74f2e9e9ddda94aea0200
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8ba0fd7f08a74f2e9e9ddda94aea0200
record_format	dspace
spelling	oai:doaj.org-article:8ba0fd7f08a74f2e9e9ddda94aea02002021-12-01T00:33:43ZMultiple Functions of Draxin/Netrin-1 Signaling in the Development of Neural Circuits in the Spinal Cord and the Brain1662-512910.3389/fnana.2021.766911https://doaj.org/article/8ba0fd7f08a74f2e9e9ddda94aea02002021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnana.2021.766911/fullhttps://doaj.org/toc/1662-5129Axon guidance proteins play key roles in the formation of neural circuits during development. We previously identified an axon guidance cue, named draxin, that has no homology with other axon guidance proteins. Draxin is essential for the development of various neural circuits including the spinal cord commissure, corpus callosum, and thalamocortical projections. Draxin has been shown to not only control axon guidance through netrin-1 receptors, deleted in colorectal cancer (Dcc), and neogenin (Neo1) but also modulate netrin-1-mediated axon guidance and fasciculation. In this review, we summarize the multifaceted functions of draxin and netrin-1 signaling in neural circuit formation in the central nervous system. Furthermore, because recent studies suggest that the distributions and functions of axon guidance cues are highly regulated by glycoproteins such as Dystroglycan and Heparan sulfate proteoglycans, we discuss a possible function of glycoproteins in draxin/netrin-1-mediated axon guidance.Giasuddin AhmedYohei ShinmyoFrontiers Media S.A.articleaxon guidancedraxinnetrin-1spinal commissural axonscorpus callosumthalamocortical projectionsNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Human anatomyQM1-695ENFrontiers in Neuroanatomy, Vol 15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	axon guidance draxin netrin-1 spinal commissural axons corpus callosum thalamocortical projections Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Human anatomy QM1-695
spellingShingle	axon guidance draxin netrin-1 spinal commissural axons corpus callosum thalamocortical projections Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Human anatomy QM1-695 Giasuddin Ahmed Yohei Shinmyo Multiple Functions of Draxin/Netrin-1 Signaling in the Development of Neural Circuits in the Spinal Cord and the Brain
description	Axon guidance proteins play key roles in the formation of neural circuits during development. We previously identified an axon guidance cue, named draxin, that has no homology with other axon guidance proteins. Draxin is essential for the development of various neural circuits including the spinal cord commissure, corpus callosum, and thalamocortical projections. Draxin has been shown to not only control axon guidance through netrin-1 receptors, deleted in colorectal cancer (Dcc), and neogenin (Neo1) but also modulate netrin-1-mediated axon guidance and fasciculation. In this review, we summarize the multifaceted functions of draxin and netrin-1 signaling in neural circuit formation in the central nervous system. Furthermore, because recent studies suggest that the distributions and functions of axon guidance cues are highly regulated by glycoproteins such as Dystroglycan and Heparan sulfate proteoglycans, we discuss a possible function of glycoproteins in draxin/netrin-1-mediated axon guidance.
format	article
author	Giasuddin Ahmed Yohei Shinmyo
author_facet	Giasuddin Ahmed Yohei Shinmyo
author_sort	Giasuddin Ahmed
title	Multiple Functions of Draxin/Netrin-1 Signaling in the Development of Neural Circuits in the Spinal Cord and the Brain
title_short	Multiple Functions of Draxin/Netrin-1 Signaling in the Development of Neural Circuits in the Spinal Cord and the Brain
title_full	Multiple Functions of Draxin/Netrin-1 Signaling in the Development of Neural Circuits in the Spinal Cord and the Brain
title_fullStr	Multiple Functions of Draxin/Netrin-1 Signaling in the Development of Neural Circuits in the Spinal Cord and the Brain
title_full_unstemmed	Multiple Functions of Draxin/Netrin-1 Signaling in the Development of Neural Circuits in the Spinal Cord and the Brain
title_sort	multiple functions of draxin/netrin-1 signaling in the development of neural circuits in the spinal cord and the brain
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/8ba0fd7f08a74f2e9e9ddda94aea0200
work_keys_str_mv	AT giasuddinahmed multiplefunctionsofdraxinnetrin1signalinginthedevelopmentofneuralcircuitsinthespinalcordandthebrain AT yoheishinmyo multiplefunctionsofdraxinnetrin1signalinginthedevelopmentofneuralcircuitsinthespinalcordandthebrain
_version_	1718406033042309120

Multiple Functions of Draxin/Netrin-1 Signaling in the Development of Neural Circuits in the Spinal Cord and the Brain

Ejemplares similares