Epigenetically reprogrammed methylation landscape drives the DNA self-assembly and serves as a universal cancer biomarker

DNA methylation is an epigenetic modification that control genetic programs. Here, the authors found that the methylation landscape influences the physicochemical properties of DNA and that it can serve as a universal cancer biomarker, and developed a one-step assay for the detection of cancer DNA.

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Autores principales:	Abu Ali Ibn Sina, Laura G. Carrascosa, Ziyu Liang, Yadveer S. Grewal, Andri Wardiana, Muhammad J. A. Shiddiky, Robert A. Gardiner, Hemamali Samaratunga, Maher K. Gandhi, Rodney J. Scott, Darren Korbie, Matt Trau
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8ba444c0c7b149acac89adbdeaa84064
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:8ba444c0c7b149acac89adbdeaa840642021-12-02T14:41:16ZEpigenetically reprogrammed methylation landscape drives the DNA self-assembly and serves as a universal cancer biomarker10.1038/s41467-018-07214-w2041-1723https://doaj.org/article/8ba444c0c7b149acac89adbdeaa840642018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07214-whttps://doaj.org/toc/2041-1723DNA methylation is an epigenetic modification that control genetic programs. Here, the authors found that the methylation landscape influences the physicochemical properties of DNA and that it can serve as a universal cancer biomarker, and developed a one-step assay for the detection of cancer DNA.Abu Ali Ibn SinaLaura G. CarrascosaZiyu LiangYadveer S. GrewalAndri WardianaMuhammad J. A. ShiddikyRobert A. GardinerHemamali SamaratungaMaher K. GandhiRodney J. ScottDarren KorbieMatt TrauNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Abu Ali Ibn Sina Laura G. Carrascosa Ziyu Liang Yadveer S. Grewal Andri Wardiana Muhammad J. A. Shiddiky Robert A. Gardiner Hemamali Samaratunga Maher K. Gandhi Rodney J. Scott Darren Korbie Matt Trau Epigenetically reprogrammed methylation landscape drives the DNA self-assembly and serves as a universal cancer biomarker
description	DNA methylation is an epigenetic modification that control genetic programs. Here, the authors found that the methylation landscape influences the physicochemical properties of DNA and that it can serve as a universal cancer biomarker, and developed a one-step assay for the detection of cancer DNA.
format	article
author	Abu Ali Ibn Sina Laura G. Carrascosa Ziyu Liang Yadveer S. Grewal Andri Wardiana Muhammad J. A. Shiddiky Robert A. Gardiner Hemamali Samaratunga Maher K. Gandhi Rodney J. Scott Darren Korbie Matt Trau
author_facet	Abu Ali Ibn Sina Laura G. Carrascosa Ziyu Liang Yadveer S. Grewal Andri Wardiana Muhammad J. A. Shiddiky Robert A. Gardiner Hemamali Samaratunga Maher K. Gandhi Rodney J. Scott Darren Korbie Matt Trau
author_sort	Abu Ali Ibn Sina
title	Epigenetically reprogrammed methylation landscape drives the DNA self-assembly and serves as a universal cancer biomarker
title_short	Epigenetically reprogrammed methylation landscape drives the DNA self-assembly and serves as a universal cancer biomarker
title_full	Epigenetically reprogrammed methylation landscape drives the DNA self-assembly and serves as a universal cancer biomarker
title_fullStr	Epigenetically reprogrammed methylation landscape drives the DNA self-assembly and serves as a universal cancer biomarker
title_full_unstemmed	Epigenetically reprogrammed methylation landscape drives the DNA self-assembly and serves as a universal cancer biomarker
title_sort	epigenetically reprogrammed methylation landscape drives the dna self-assembly and serves as a universal cancer biomarker
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/8ba444c0c7b149acac89adbdeaa84064
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Epigenetically reprogrammed methylation landscape drives the DNA self-assembly and serves as a universal cancer biomarker

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