Healing of the nasal septal mucosa in an experimental rabbit model of mucosal injury
Objective: The aim of this study was to investigate the regeneration process of the nasal mucosa after a surgically created mucosal defect in the rabbit nasal septum, and to evaluate the effects of different interventions. Methods: A 7 mm-diameter circular mucosal defect was made in the septum of fo...
Guardado en:
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
KeAi Communications Co., Ltd.
2017
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/8ba6473eb5ed457d9e09a2617d9675a7 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:8ba6473eb5ed457d9e09a2617d9675a7 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:8ba6473eb5ed457d9e09a2617d9675a72021-12-02T14:21:35ZHealing of the nasal septal mucosa in an experimental rabbit model of mucosal injury2095-881110.1016/j.wjorl.2017.02.004https://doaj.org/article/8ba6473eb5ed457d9e09a2617d9675a72017-03-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095881116301019https://doaj.org/toc/2095-8811Objective: The aim of this study was to investigate the regeneration process of the nasal mucosa after a surgically created mucosal defect in the rabbit nasal septum, and to evaluate the effects of different interventions. Methods: A 7 mm-diameter circular mucosal defect was made in the septum of forty New Zealand white rabbits. The rabbits were divided into four groups (ten rabbits in each group) according to the type of intervention; no treatment (control), silastic sheet (SS), hyaluronic acid (HA), and silastic sheet and hyaluronic acid (SS + HA) group. The diameter of the defect, mucosal thickness, epithelial thickness, and ciliated cell count were evaluated every week for five weeks. Results: The average diameter of the defect in the control group were 5.1, 3.65, 1.2, 0.75, and 0.05 mm at postoperative 1, 2, 3, 4, and 5 weeks. In the SS group, the diameter decreased to 4.35, 2.1, 0.35, 0.15, and 0 mm at postoperative 1, 2, 3, 4, and 5 weeks, respectively, in which the mean diameter of the postoperative week 2 was significantly smaller compared to control (3.65 mm vs. 2.1 mm, P = 0.039). For the HA group and SS + HA group, the diameter of the defect did not show a significant difference from the control group during the five weeks. The mucosal thickness, epithelial thickness, and ciliated cell count of the regenerated mucosa were not significantly different among the groups. Conclusion: The regeneration process of the nasal septal mucosa was identified using a novel rabbit model. Mucosal regeneration can be accelerated by applying silastic sheets. Keywords: Nasal septum, Nasal mucosa, Mucous membrane, Hyaluronic acid, RabbitsKyu Young ChoiSung Woo ChoJun-Jae ChoiYu-Lian ZhangDae Woo KimDoo Hee HanHyun Jik KimDong-Young KimChae-Seo RheeTae-Bin WonKeAi Communications Co., Ltd.articleOtorhinolaryngologyRF1-547SurgeryRD1-811ENWorld Journal of Otorhinolaryngology-Head and Neck Surgery, Vol 3, Iss 1, Pp 17-23 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Otorhinolaryngology RF1-547 Surgery RD1-811 |
| spellingShingle |
Otorhinolaryngology RF1-547 Surgery RD1-811 Kyu Young Choi Sung Woo Cho Jun-Jae Choi Yu-Lian Zhang Dae Woo Kim Doo Hee Han Hyun Jik Kim Dong-Young Kim Chae-Seo Rhee Tae-Bin Won Healing of the nasal septal mucosa in an experimental rabbit model of mucosal injury |
| description |
Objective: The aim of this study was to investigate the regeneration process of the nasal mucosa after a surgically created mucosal defect in the rabbit nasal septum, and to evaluate the effects of different interventions. Methods: A 7 mm-diameter circular mucosal defect was made in the septum of forty New Zealand white rabbits. The rabbits were divided into four groups (ten rabbits in each group) according to the type of intervention; no treatment (control), silastic sheet (SS), hyaluronic acid (HA), and silastic sheet and hyaluronic acid (SS + HA) group. The diameter of the defect, mucosal thickness, epithelial thickness, and ciliated cell count were evaluated every week for five weeks. Results: The average diameter of the defect in the control group were 5.1, 3.65, 1.2, 0.75, and 0.05 mm at postoperative 1, 2, 3, 4, and 5 weeks. In the SS group, the diameter decreased to 4.35, 2.1, 0.35, 0.15, and 0 mm at postoperative 1, 2, 3, 4, and 5 weeks, respectively, in which the mean diameter of the postoperative week 2 was significantly smaller compared to control (3.65 mm vs. 2.1 mm, P = 0.039). For the HA group and SS + HA group, the diameter of the defect did not show a significant difference from the control group during the five weeks. The mucosal thickness, epithelial thickness, and ciliated cell count of the regenerated mucosa were not significantly different among the groups. Conclusion: The regeneration process of the nasal septal mucosa was identified using a novel rabbit model. Mucosal regeneration can be accelerated by applying silastic sheets. Keywords: Nasal septum, Nasal mucosa, Mucous membrane, Hyaluronic acid, Rabbits |
| format |
article |
| author |
Kyu Young Choi Sung Woo Cho Jun-Jae Choi Yu-Lian Zhang Dae Woo Kim Doo Hee Han Hyun Jik Kim Dong-Young Kim Chae-Seo Rhee Tae-Bin Won |
| author_facet |
Kyu Young Choi Sung Woo Cho Jun-Jae Choi Yu-Lian Zhang Dae Woo Kim Doo Hee Han Hyun Jik Kim Dong-Young Kim Chae-Seo Rhee Tae-Bin Won |
| author_sort |
Kyu Young Choi |
| title |
Healing of the nasal septal mucosa in an experimental rabbit model of mucosal injury |
| title_short |
Healing of the nasal septal mucosa in an experimental rabbit model of mucosal injury |
| title_full |
Healing of the nasal septal mucosa in an experimental rabbit model of mucosal injury |
| title_fullStr |
Healing of the nasal septal mucosa in an experimental rabbit model of mucosal injury |
| title_full_unstemmed |
Healing of the nasal septal mucosa in an experimental rabbit model of mucosal injury |
| title_sort |
healing of the nasal septal mucosa in an experimental rabbit model of mucosal injury |
| publisher |
KeAi Communications Co., Ltd. |
| publishDate |
2017 |
| url |
https://doaj.org/article/8ba6473eb5ed457d9e09a2617d9675a7 |
| work_keys_str_mv |
AT kyuyoungchoi healingofthenasalseptalmucosainanexperimentalrabbitmodelofmucosalinjury AT sungwoocho healingofthenasalseptalmucosainanexperimentalrabbitmodelofmucosalinjury AT junjaechoi healingofthenasalseptalmucosainanexperimentalrabbitmodelofmucosalinjury AT yulianzhang healingofthenasalseptalmucosainanexperimentalrabbitmodelofmucosalinjury AT daewookim healingofthenasalseptalmucosainanexperimentalrabbitmodelofmucosalinjury AT dooheehan healingofthenasalseptalmucosainanexperimentalrabbitmodelofmucosalinjury AT hyunjikkim healingofthenasalseptalmucosainanexperimentalrabbitmodelofmucosalinjury AT dongyoungkim healingofthenasalseptalmucosainanexperimentalrabbitmodelofmucosalinjury AT chaeseorhee healingofthenasalseptalmucosainanexperimentalrabbitmodelofmucosalinjury AT taebinwon healingofthenasalseptalmucosainanexperimentalrabbitmodelofmucosalinjury |
| _version_ |
1718391559906394112 |