The Directionality of Fronto-Posterior Brain Connectivity Is Associated with the Degree of Individual Autistic Traits

Altered patterns of brain connectivity have been found in autism spectrum disorder (ASD) and associated with specific symptoms and behavioral features. Growing evidence suggests that the autistic peculiarities are not confined to the clinical population but extend along a continuum between healthy a...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Luca Tarasi, Elisa Magosso, Giulia Ricci, Mauro Ursino, Vincenzo Romei
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	autism spectrum disorder autistic quotient EEG Granger causality bottom-up and top-down connectivity Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/8baa24ac0caa44f482a087374718f8d6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8baa24ac0caa44f482a087374718f8d6
record_format	dspace
spelling	oai:doaj.org-article:8baa24ac0caa44f482a087374718f8d62021-11-25T16:57:32ZThe Directionality of Fronto-Posterior Brain Connectivity Is Associated with the Degree of Individual Autistic Traits10.3390/brainsci111114432076-3425https://doaj.org/article/8baa24ac0caa44f482a087374718f8d62021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3425/11/11/1443https://doaj.org/toc/2076-3425Altered patterns of brain connectivity have been found in autism spectrum disorder (ASD) and associated with specific symptoms and behavioral features. Growing evidence suggests that the autistic peculiarities are not confined to the clinical population but extend along a continuum between healthy and maladaptive conditions. The aim of this study was to investigate whether a differentiated connectivity pattern could also be tracked along the continuum of autistic traits in a non-clinical population. A Granger causality analysis conducted on a resting-state EEG recording showed that connectivity along the posterior-frontal gradient is sensitive to the magnitude of individual autistic traits and mostly conveyed through fast oscillatory activity. Specifically, participants with higher autistic traits were characterized by a prevalence of ascending connections starting from posterior regions ramping the cortical hierarchy. These findings point to the presence of a tendency within the neural mapping of individuals with higher autistic features in conveying proportionally more bottom-up information. This pattern of findings mimics those found in clinical forms of autism, supporting the idea of a neurobiological continuum between autistic traits and ASD.Luca TarasiElisa MagossoGiulia RicciMauro UrsinoVincenzo RomeiMDPI AGarticleautism spectrum disorderautistic quotientEEGGranger causalitybottom-up and top-down connectivityNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBrain Sciences, Vol 11, Iss 1443, p 1443 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	autism spectrum disorder autistic quotient EEG Granger causality bottom-up and top-down connectivity Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	autism spectrum disorder autistic quotient EEG Granger causality bottom-up and top-down connectivity Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Luca Tarasi Elisa Magosso Giulia Ricci Mauro Ursino Vincenzo Romei The Directionality of Fronto-Posterior Brain Connectivity Is Associated with the Degree of Individual Autistic Traits
description	Altered patterns of brain connectivity have been found in autism spectrum disorder (ASD) and associated with specific symptoms and behavioral features. Growing evidence suggests that the autistic peculiarities are not confined to the clinical population but extend along a continuum between healthy and maladaptive conditions. The aim of this study was to investigate whether a differentiated connectivity pattern could also be tracked along the continuum of autistic traits in a non-clinical population. A Granger causality analysis conducted on a resting-state EEG recording showed that connectivity along the posterior-frontal gradient is sensitive to the magnitude of individual autistic traits and mostly conveyed through fast oscillatory activity. Specifically, participants with higher autistic traits were characterized by a prevalence of ascending connections starting from posterior regions ramping the cortical hierarchy. These findings point to the presence of a tendency within the neural mapping of individuals with higher autistic features in conveying proportionally more bottom-up information. This pattern of findings mimics those found in clinical forms of autism, supporting the idea of a neurobiological continuum between autistic traits and ASD.
format	article
author	Luca Tarasi Elisa Magosso Giulia Ricci Mauro Ursino Vincenzo Romei
author_facet	Luca Tarasi Elisa Magosso Giulia Ricci Mauro Ursino Vincenzo Romei
author_sort	Luca Tarasi
title	The Directionality of Fronto-Posterior Brain Connectivity Is Associated with the Degree of Individual Autistic Traits
title_short	The Directionality of Fronto-Posterior Brain Connectivity Is Associated with the Degree of Individual Autistic Traits
title_full	The Directionality of Fronto-Posterior Brain Connectivity Is Associated with the Degree of Individual Autistic Traits
title_fullStr	The Directionality of Fronto-Posterior Brain Connectivity Is Associated with the Degree of Individual Autistic Traits
title_full_unstemmed	The Directionality of Fronto-Posterior Brain Connectivity Is Associated with the Degree of Individual Autistic Traits
title_sort	directionality of fronto-posterior brain connectivity is associated with the degree of individual autistic traits
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/8baa24ac0caa44f482a087374718f8d6
work_keys_str_mv	AT lucatarasi thedirectionalityoffrontoposteriorbrainconnectivityisassociatedwiththedegreeofindividualautistictraits AT elisamagosso thedirectionalityoffrontoposteriorbrainconnectivityisassociatedwiththedegreeofindividualautistictraits AT giuliaricci thedirectionalityoffrontoposteriorbrainconnectivityisassociatedwiththedegreeofindividualautistictraits AT mauroursino thedirectionalityoffrontoposteriorbrainconnectivityisassociatedwiththedegreeofindividualautistictraits AT vincenzoromei thedirectionalityoffrontoposteriorbrainconnectivityisassociatedwiththedegreeofindividualautistictraits AT lucatarasi directionalityoffrontoposteriorbrainconnectivityisassociatedwiththedegreeofindividualautistictraits AT elisamagosso directionalityoffrontoposteriorbrainconnectivityisassociatedwiththedegreeofindividualautistictraits AT giuliaricci directionalityoffrontoposteriorbrainconnectivityisassociatedwiththedegreeofindividualautistictraits AT mauroursino directionalityoffrontoposteriorbrainconnectivityisassociatedwiththedegreeofindividualautistictraits AT vincenzoromei directionalityoffrontoposteriorbrainconnectivityisassociatedwiththedegreeofindividualautistictraits
_version_	1718412849287528448

The Directionality of Fronto-Posterior Brain Connectivity Is Associated with the Degree of Individual Autistic Traits

Ejemplares similares