Bladder cancer therapy using a conformationally fluid tumoricidal peptide complex
Partially unfolded alpha-lactalbumin forms an oleic acid complex with antitumorigenic properties. Here, the authors define a structurally flexible, peptide-based oleate complex and report a phase I/II clinical trial where this complex is used to treat patients with bladder cancer.
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Nature Portfolio
2021
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| Acceso en línea: | https://doaj.org/article/8bab807c461e46258408ec0d77b8d766 |
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oai:doaj.org-article:8bab807c461e46258408ec0d77b8d7662021-12-02T17:52:09ZBladder cancer therapy using a conformationally fluid tumoricidal peptide complex10.1038/s41467-021-23748-y2041-1723https://doaj.org/article/8bab807c461e46258408ec0d77b8d7662021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23748-yhttps://doaj.org/toc/2041-1723Partially unfolded alpha-lactalbumin forms an oleic acid complex with antitumorigenic properties. Here, the authors define a structurally flexible, peptide-based oleate complex and report a phase I/II clinical trial where this complex is used to treat patients with bladder cancer.Antonín BrisudaJames C. S. HoPancham S. KandiyalJustin T-Y. NgInes AmbiteDaniel S. C. ButlerJaromir HáčekMurphy Lam Yim WanThi Hien TranAftab NadeemTuan Hiep TranAnna HastingsPetter StormDaniel L. FortunatiParisa EsmaeiliHana NovotnaJakub HorňákY. G. MuK. H. MokMarek BabjukCatharina SvanborgNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Antonín Brisuda James C. S. Ho Pancham S. Kandiyal Justin T-Y. Ng Ines Ambite Daniel S. C. Butler Jaromir Háček Murphy Lam Yim Wan Thi Hien Tran Aftab Nadeem Tuan Hiep Tran Anna Hastings Petter Storm Daniel L. Fortunati Parisa Esmaeili Hana Novotna Jakub Horňák Y. G. Mu K. H. Mok Marek Babjuk Catharina Svanborg Bladder cancer therapy using a conformationally fluid tumoricidal peptide complex |
| description |
Partially unfolded alpha-lactalbumin forms an oleic acid complex with antitumorigenic properties. Here, the authors define a structurally flexible, peptide-based oleate complex and report a phase I/II clinical trial where this complex is used to treat patients with bladder cancer. |
| format |
article |
| author |
Antonín Brisuda James C. S. Ho Pancham S. Kandiyal Justin T-Y. Ng Ines Ambite Daniel S. C. Butler Jaromir Háček Murphy Lam Yim Wan Thi Hien Tran Aftab Nadeem Tuan Hiep Tran Anna Hastings Petter Storm Daniel L. Fortunati Parisa Esmaeili Hana Novotna Jakub Horňák Y. G. Mu K. H. Mok Marek Babjuk Catharina Svanborg |
| author_facet |
Antonín Brisuda James C. S. Ho Pancham S. Kandiyal Justin T-Y. Ng Ines Ambite Daniel S. C. Butler Jaromir Háček Murphy Lam Yim Wan Thi Hien Tran Aftab Nadeem Tuan Hiep Tran Anna Hastings Petter Storm Daniel L. Fortunati Parisa Esmaeili Hana Novotna Jakub Horňák Y. G. Mu K. H. Mok Marek Babjuk Catharina Svanborg |
| author_sort |
Antonín Brisuda |
| title |
Bladder cancer therapy using a conformationally fluid tumoricidal peptide complex |
| title_short |
Bladder cancer therapy using a conformationally fluid tumoricidal peptide complex |
| title_full |
Bladder cancer therapy using a conformationally fluid tumoricidal peptide complex |
| title_fullStr |
Bladder cancer therapy using a conformationally fluid tumoricidal peptide complex |
| title_full_unstemmed |
Bladder cancer therapy using a conformationally fluid tumoricidal peptide complex |
| title_sort |
bladder cancer therapy using a conformationally fluid tumoricidal peptide complex |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/8bab807c461e46258408ec0d77b8d766 |
| work_keys_str_mv |
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| _version_ |
1718379239063945216 |