The Effect of Phototherapy on Serum Level of Tumor Necrosis Factor Alpha in Neonates

Background: Jaundice is one of the most common conditions confronting neonatologists daily. Phototherapy is generally regarded as a safe method for treating hyperbilirubinemia, but it may also lead to undesired effects, one of these effects that it can affect the function of the immune system of the...

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Autores principales:	Mohamed Neam, Mohamed Zannoun
Formato:	article
Lenguaje:	EN
Publicado:	Al-Azhar University, Faculty of Medicine (Damietta) 2020
Materias:	phototherapy jaundice immune system cytokines neonate Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8bad20a3a7a244bdb9c76040bab197e0
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spelling	oai:doaj.org-article:8bad20a3a7a244bdb9c76040bab197e02021-12-02T13:52:45ZThe Effect of Phototherapy on Serum Level of Tumor Necrosis Factor Alpha in Neonates2636-41742682-378010.21608/ijma.2019.12655.1004https://doaj.org/article/8bad20a3a7a244bdb9c76040bab197e02020-01-01T00:00:00Zhttps://ijma.journals.ekb.eg/article_55919_e2a9773c283cc915f103b895f0e0ce9b.pdfhttps://doaj.org/toc/2636-4174https://doaj.org/toc/2682-3780Background: Jaundice is one of the most common conditions confronting neonatologists daily. Phototherapy is generally regarded as a safe method for treating hyperbilirubinemia, but it may also lead to undesired effects, one of these effects that it can affect the function of the immune system of the newborn. Aim of the work: The aim of the work was to study the effect of phototherapy on the serum level of tumor necrosis factor- alpha [TNF-α] in neonates. Patients and methods: A total of 35 cases of term neonates with Neonatal Jaundice and indirect hyperbilirubinemia high to the level that need phototherapy for 72hrs or more according to the guidelines of the American Academy of Pediatrics were included in this study, and 15 healthy matched newborns were selected as controls. TNF-α was measured before exposure and after 72 hours phototherapy and from control group at the time of examination. Serum levels of TNF alpha were measured using enzyme linked immunosorbent assay kits. Results: The results showed that there was no statistically significant in patient group before phototherapy in comparison to control group as regards TNF-α, patient demographics or laboratory data. On the other side, serum TNF-α levels significantly increased after exposure to phototherapy for 72 hours when compared to values before phototherapy (151.49±61.97 vs 61.36±31.96 respectively), indicating the influence of phototherapy on serum level of TNF-α. Conclusion: The results demonstrated increased serum TNF-α level after 72 hours may affect the immune system in neonates.Mohamed NeamMohamed ZannounAl-Azhar University, Faculty of Medicine (Damietta)articlephototherapyjaundiceimmune systemcytokinesneonateMedicine (General)R5-920ENInternational Journal of Medical Arts, Vol 2, Iss 1, Pp 157-161 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	phototherapy jaundice immune system cytokines neonate Medicine (General) R5-920
spellingShingle	phototherapy jaundice immune system cytokines neonate Medicine (General) R5-920 Mohamed Neam Mohamed Zannoun The Effect of Phototherapy on Serum Level of Tumor Necrosis Factor Alpha in Neonates
description	Background: Jaundice is one of the most common conditions confronting neonatologists daily. Phototherapy is generally regarded as a safe method for treating hyperbilirubinemia, but it may also lead to undesired effects, one of these effects that it can affect the function of the immune system of the newborn. Aim of the work: The aim of the work was to study the effect of phototherapy on the serum level of tumor necrosis factor- alpha [TNF-α] in neonates. Patients and methods: A total of 35 cases of term neonates with Neonatal Jaundice and indirect hyperbilirubinemia high to the level that need phototherapy for 72hrs or more according to the guidelines of the American Academy of Pediatrics were included in this study, and 15 healthy matched newborns were selected as controls. TNF-α was measured before exposure and after 72 hours phototherapy and from control group at the time of examination. Serum levels of TNF alpha were measured using enzyme linked immunosorbent assay kits. Results: The results showed that there was no statistically significant in patient group before phototherapy in comparison to control group as regards TNF-α, patient demographics or laboratory data. On the other side, serum TNF-α levels significantly increased after exposure to phototherapy for 72 hours when compared to values before phototherapy (151.49±61.97 vs 61.36±31.96 respectively), indicating the influence of phototherapy on serum level of TNF-α. Conclusion: The results demonstrated increased serum TNF-α level after 72 hours may affect the immune system in neonates.
format	article
author	Mohamed Neam Mohamed Zannoun
author_facet	Mohamed Neam Mohamed Zannoun
author_sort	Mohamed Neam
title	The Effect of Phototherapy on Serum Level of Tumor Necrosis Factor Alpha in Neonates
title_short	The Effect of Phototherapy on Serum Level of Tumor Necrosis Factor Alpha in Neonates
title_full	The Effect of Phototherapy on Serum Level of Tumor Necrosis Factor Alpha in Neonates
title_fullStr	The Effect of Phototherapy on Serum Level of Tumor Necrosis Factor Alpha in Neonates
title_full_unstemmed	The Effect of Phototherapy on Serum Level of Tumor Necrosis Factor Alpha in Neonates
title_sort	effect of phototherapy on serum level of tumor necrosis factor alpha in neonates
publisher	Al-Azhar University, Faculty of Medicine (Damietta)
publishDate	2020
url	https://doaj.org/article/8bad20a3a7a244bdb9c76040bab197e0
work_keys_str_mv	AT mohamedneam theeffectofphototherapyonserumleveloftumornecrosisfactoralphainneonates AT mohamedzannoun theeffectofphototherapyonserumleveloftumornecrosisfactoralphainneonates AT mohamedneam effectofphototherapyonserumleveloftumornecrosisfactoralphainneonates AT mohamedzannoun effectofphototherapyonserumleveloftumornecrosisfactoralphainneonates
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The Effect of Phototherapy on Serum Level of Tumor Necrosis Factor Alpha in Neonates

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