CIC protein instability contributes to tumorigenesis in glioblastoma

Capicua (CIC) is a tumour suppressor in oligodendroglioma. Here, the authors show that ERK activation mediates CIC regulation via ubiquitination and degradation by PJA1 and a degradation resistant form of CIC enhances efficacy of ERK inhibition in glioblastoma.

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Autores principales:	Severa Bunda, Pardeep Heir, Julie Metcalf, Annie Si Cong Li, Sameer Agnihotri, Stefan Pusch, Mamatjan Yasin, Mira Li, Kelly Burrell, Sheila Mansouri, Olivia Singh, Mark Wilson, Amir Alamsahebpour, Romina Nejad, Bethany Choi, David Kim, Andreas von Deimling, Gelareh Zadeh, Kenneth Aldape
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8bad397c36f64a45b7ac70d9557fd054
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spelling	oai:doaj.org-article:8bad397c36f64a45b7ac70d9557fd0542021-12-02T14:39:19ZCIC protein instability contributes to tumorigenesis in glioblastoma10.1038/s41467-018-08087-92041-1723https://doaj.org/article/8bad397c36f64a45b7ac70d9557fd0542019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08087-9https://doaj.org/toc/2041-1723Capicua (CIC) is a tumour suppressor in oligodendroglioma. Here, the authors show that ERK activation mediates CIC regulation via ubiquitination and degradation by PJA1 and a degradation resistant form of CIC enhances efficacy of ERK inhibition in glioblastoma.Severa BundaPardeep HeirJulie MetcalfAnnie Si Cong LiSameer AgnihotriStefan PuschMamatjan YasinMira LiKelly BurrellSheila MansouriOlivia SinghMark WilsonAmir AlamsahebpourRomina NejadBethany ChoiDavid KimAndreas von DeimlingGelareh ZadehKenneth AldapeNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Severa Bunda Pardeep Heir Julie Metcalf Annie Si Cong Li Sameer Agnihotri Stefan Pusch Mamatjan Yasin Mira Li Kelly Burrell Sheila Mansouri Olivia Singh Mark Wilson Amir Alamsahebpour Romina Nejad Bethany Choi David Kim Andreas von Deimling Gelareh Zadeh Kenneth Aldape CIC protein instability contributes to tumorigenesis in glioblastoma
description	Capicua (CIC) is a tumour suppressor in oligodendroglioma. Here, the authors show that ERK activation mediates CIC regulation via ubiquitination and degradation by PJA1 and a degradation resistant form of CIC enhances efficacy of ERK inhibition in glioblastoma.
format	article
author	Severa Bunda Pardeep Heir Julie Metcalf Annie Si Cong Li Sameer Agnihotri Stefan Pusch Mamatjan Yasin Mira Li Kelly Burrell Sheila Mansouri Olivia Singh Mark Wilson Amir Alamsahebpour Romina Nejad Bethany Choi David Kim Andreas von Deimling Gelareh Zadeh Kenneth Aldape
author_facet	Severa Bunda Pardeep Heir Julie Metcalf Annie Si Cong Li Sameer Agnihotri Stefan Pusch Mamatjan Yasin Mira Li Kelly Burrell Sheila Mansouri Olivia Singh Mark Wilson Amir Alamsahebpour Romina Nejad Bethany Choi David Kim Andreas von Deimling Gelareh Zadeh Kenneth Aldape
author_sort	Severa Bunda
title	CIC protein instability contributes to tumorigenesis in glioblastoma
title_short	CIC protein instability contributes to tumorigenesis in glioblastoma
title_full	CIC protein instability contributes to tumorigenesis in glioblastoma
title_fullStr	CIC protein instability contributes to tumorigenesis in glioblastoma
title_full_unstemmed	CIC protein instability contributes to tumorigenesis in glioblastoma
title_sort	cic protein instability contributes to tumorigenesis in glioblastoma
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/8bad397c36f64a45b7ac70d9557fd054
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CIC protein instability contributes to tumorigenesis in glioblastoma

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