Relaxed sequence constraints favor mutational freedom in idiosyncratic metazoan mitochondrial tRNAs

Bilaterian mitochondria-encoded tRNA genes accumulate mutations at higher rates than their cytoplasmic tRNA counterparts, resulting in idiosyncratic structures. Here the authors suggest an evolutionary basis for the observed mutational freedom of mitochondrial (mt) tRNAs and reveal the associated co...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Bernhard Kuhle, Joseph Chihade, Paul Schimmel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8baf1f06210545d3a902682fc8ee32eb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8baf1f06210545d3a902682fc8ee32eb
record_format	dspace
spelling	oai:doaj.org-article:8baf1f06210545d3a902682fc8ee32eb2021-12-02T14:41:05ZRelaxed sequence constraints favor mutational freedom in idiosyncratic metazoan mitochondrial tRNAs10.1038/s41467-020-14725-y2041-1723https://doaj.org/article/8baf1f06210545d3a902682fc8ee32eb2020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14725-yhttps://doaj.org/toc/2041-1723Bilaterian mitochondria-encoded tRNA genes accumulate mutations at higher rates than their cytoplasmic tRNA counterparts, resulting in idiosyncratic structures. Here the authors suggest an evolutionary basis for the observed mutational freedom of mitochondrial (mt) tRNAs and reveal the associated co-adaptive structural and functional changes in mt aminoacyl-tRNA synthetases.Bernhard KuhleJoseph ChihadePaul SchimmelNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bernhard Kuhle Joseph Chihade Paul Schimmel Relaxed sequence constraints favor mutational freedom in idiosyncratic metazoan mitochondrial tRNAs
description	Bilaterian mitochondria-encoded tRNA genes accumulate mutations at higher rates than their cytoplasmic tRNA counterparts, resulting in idiosyncratic structures. Here the authors suggest an evolutionary basis for the observed mutational freedom of mitochondrial (mt) tRNAs and reveal the associated co-adaptive structural and functional changes in mt aminoacyl-tRNA synthetases.
format	article
author	Bernhard Kuhle Joseph Chihade Paul Schimmel
author_facet	Bernhard Kuhle Joseph Chihade Paul Schimmel
author_sort	Bernhard Kuhle
title	Relaxed sequence constraints favor mutational freedom in idiosyncratic metazoan mitochondrial tRNAs
title_short	Relaxed sequence constraints favor mutational freedom in idiosyncratic metazoan mitochondrial tRNAs
title_full	Relaxed sequence constraints favor mutational freedom in idiosyncratic metazoan mitochondrial tRNAs
title_fullStr	Relaxed sequence constraints favor mutational freedom in idiosyncratic metazoan mitochondrial tRNAs
title_full_unstemmed	Relaxed sequence constraints favor mutational freedom in idiosyncratic metazoan mitochondrial tRNAs
title_sort	relaxed sequence constraints favor mutational freedom in idiosyncratic metazoan mitochondrial trnas
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8baf1f06210545d3a902682fc8ee32eb
work_keys_str_mv	AT bernhardkuhle relaxedsequenceconstraintsfavormutationalfreedominidiosyncraticmetazoanmitochondrialtrnas AT josephchihade relaxedsequenceconstraintsfavormutationalfreedominidiosyncraticmetazoanmitochondrialtrnas AT paulschimmel relaxedsequenceconstraintsfavormutationalfreedominidiosyncraticmetazoanmitochondrialtrnas
_version_	1718390005254062080

Relaxed sequence constraints favor mutational freedom in idiosyncratic metazoan mitochondrial tRNAs

Ejemplares similares