Pro-inflammatory hepatic macrophages generate ROS through NADPH oxidase 2 via endocytosis of monomeric TLR4–MD2 complex

Pro-inflammatory hepatic macrophages generate ROS through NADPH oxidase 2 via endocytosis of monomeric TLR4–MD2 complex

Reactive species of oxygen promote the development of hepatic steatosis. Here, Kim et al. demonstrate that palmitate stimulates macrophage infiltration and increases oxidative stress during steatosis by binding to the TLR4–MD2 complex, which results in the activation of NOX2.

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Detalles Bibliográficos
Autores principales: So Yeon Kim, Jong-Min Jeong, Soo Jin Kim, Wonhyo Seo, Myung-Ho Kim, Won-Mook Choi, Wonbeak Yoo, Jun-Hee Lee, Young-Ri Shim, Hyon-Seung Yi, Young-Sun Lee, Hyuk Soo Eun, Byung Seok Lee, Kwangsik Chun, Suk-Jo Kang, Sun Chang Kim, Bin Gao, George Kunos, Ho Min Kim, Won-Il Jeong
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/8bb1e950316b49bfbfc161b1e107780f
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Sumario:Reactive species of oxygen promote the development of hepatic steatosis. Here, Kim et al. demonstrate that palmitate stimulates macrophage infiltration and increases oxidative stress during steatosis by binding to the TLR4–MD2 complex, which results in the activation of NOX2.

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