Pro-inflammatory hepatic macrophages generate ROS through NADPH oxidase 2 via endocytosis of monomeric TLR4–MD2 complex

Reactive species of oxygen promote the development of hepatic steatosis. Here, Kim et al. demonstrate that palmitate stimulates macrophage infiltration and increases oxidative stress during steatosis by binding to the TLR4–MD2 complex, which results in the activation of NOX2.

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Autores principales:	So Yeon Kim, Jong-Min Jeong, Soo Jin Kim, Wonhyo Seo, Myung-Ho Kim, Won-Mook Choi, Wonbeak Yoo, Jun-Hee Lee, Young-Ri Shim, Hyon-Seung Yi, Young-Sun Lee, Hyuk Soo Eun, Byung Seok Lee, Kwangsik Chun, Suk-Jo Kang, Sun Chang Kim, Bin Gao, George Kunos, Ho Min Kim, Won-Il Jeong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8bb1e950316b49bfbfc161b1e107780f
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spelling	oai:doaj.org-article:8bb1e950316b49bfbfc161b1e107780f2021-12-02T14:40:48ZPro-inflammatory hepatic macrophages generate ROS through NADPH oxidase 2 via endocytosis of monomeric TLR4–MD2 complex10.1038/s41467-017-02325-22041-1723https://doaj.org/article/8bb1e950316b49bfbfc161b1e107780f2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02325-2https://doaj.org/toc/2041-1723Reactive species of oxygen promote the development of hepatic steatosis. Here, Kim et al. demonstrate that palmitate stimulates macrophage infiltration and increases oxidative stress during steatosis by binding to the TLR4–MD2 complex, which results in the activation of NOX2.So Yeon KimJong-Min JeongSoo Jin KimWonhyo SeoMyung-Ho KimWon-Mook ChoiWonbeak YooJun-Hee LeeYoung-Ri ShimHyon-Seung YiYoung-Sun LeeHyuk Soo EunByung Seok LeeKwangsik ChunSuk-Jo KangSun Chang KimBin GaoGeorge KunosHo Min KimWon-Il JeongNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q So Yeon Kim Jong-Min Jeong Soo Jin Kim Wonhyo Seo Myung-Ho Kim Won-Mook Choi Wonbeak Yoo Jun-Hee Lee Young-Ri Shim Hyon-Seung Yi Young-Sun Lee Hyuk Soo Eun Byung Seok Lee Kwangsik Chun Suk-Jo Kang Sun Chang Kim Bin Gao George Kunos Ho Min Kim Won-Il Jeong Pro-inflammatory hepatic macrophages generate ROS through NADPH oxidase 2 via endocytosis of monomeric TLR4–MD2 complex
description	Reactive species of oxygen promote the development of hepatic steatosis. Here, Kim et al. demonstrate that palmitate stimulates macrophage infiltration and increases oxidative stress during steatosis by binding to the TLR4–MD2 complex, which results in the activation of NOX2.
format	article
author	So Yeon Kim Jong-Min Jeong Soo Jin Kim Wonhyo Seo Myung-Ho Kim Won-Mook Choi Wonbeak Yoo Jun-Hee Lee Young-Ri Shim Hyon-Seung Yi Young-Sun Lee Hyuk Soo Eun Byung Seok Lee Kwangsik Chun Suk-Jo Kang Sun Chang Kim Bin Gao George Kunos Ho Min Kim Won-Il Jeong
author_facet	So Yeon Kim Jong-Min Jeong Soo Jin Kim Wonhyo Seo Myung-Ho Kim Won-Mook Choi Wonbeak Yoo Jun-Hee Lee Young-Ri Shim Hyon-Seung Yi Young-Sun Lee Hyuk Soo Eun Byung Seok Lee Kwangsik Chun Suk-Jo Kang Sun Chang Kim Bin Gao George Kunos Ho Min Kim Won-Il Jeong
author_sort	So Yeon Kim
title	Pro-inflammatory hepatic macrophages generate ROS through NADPH oxidase 2 via endocytosis of monomeric TLR4–MD2 complex
title_short	Pro-inflammatory hepatic macrophages generate ROS through NADPH oxidase 2 via endocytosis of monomeric TLR4–MD2 complex
title_full	Pro-inflammatory hepatic macrophages generate ROS through NADPH oxidase 2 via endocytosis of monomeric TLR4–MD2 complex
title_fullStr	Pro-inflammatory hepatic macrophages generate ROS through NADPH oxidase 2 via endocytosis of monomeric TLR4–MD2 complex
title_full_unstemmed	Pro-inflammatory hepatic macrophages generate ROS through NADPH oxidase 2 via endocytosis of monomeric TLR4–MD2 complex
title_sort	pro-inflammatory hepatic macrophages generate ros through nadph oxidase 2 via endocytosis of monomeric tlr4–md2 complex
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8bb1e950316b49bfbfc161b1e107780f
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Pro-inflammatory hepatic macrophages generate ROS through NADPH oxidase 2 via endocytosis of monomeric TLR4–MD2 complex

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