A high-resolution description of β1-adrenergic receptor functional dynamics and allosteric coupling from backbone NMR

Signal transmission and regulation of G-protein-coupled receptors (GPCRs) by ligands occurs via modulation of complex conformational equilibria. Here authors quantify these equilibria and their dynamics in the β1-adrenergic receptor in its apo form and seven ligand complexes using NMR.

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Autores principales:	Anne Grahl, Layara Akemi Abiko, Shin Isogai, Timothy Sharpe, Stephan Grzesiek
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8bb35a77f6744d2dbe67f65cb91afeaf
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spelling	oai:doaj.org-article:8bb35a77f6744d2dbe67f65cb91afeaf2021-12-02T14:42:47ZA high-resolution description of β1-adrenergic receptor functional dynamics and allosteric coupling from backbone NMR10.1038/s41467-020-15864-y2041-1723https://doaj.org/article/8bb35a77f6744d2dbe67f65cb91afeaf2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15864-yhttps://doaj.org/toc/2041-1723Signal transmission and regulation of G-protein-coupled receptors (GPCRs) by ligands occurs via modulation of complex conformational equilibria. Here authors quantify these equilibria and their dynamics in the β1-adrenergic receptor in its apo form and seven ligand complexes using NMR.Anne GrahlLayara Akemi AbikoShin IsogaiTimothy SharpeStephan GrzesiekNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anne Grahl Layara Akemi Abiko Shin Isogai Timothy Sharpe Stephan Grzesiek A high-resolution description of β1-adrenergic receptor functional dynamics and allosteric coupling from backbone NMR
description	Signal transmission and regulation of G-protein-coupled receptors (GPCRs) by ligands occurs via modulation of complex conformational equilibria. Here authors quantify these equilibria and their dynamics in the β1-adrenergic receptor in its apo form and seven ligand complexes using NMR.
format	article
author	Anne Grahl Layara Akemi Abiko Shin Isogai Timothy Sharpe Stephan Grzesiek
author_facet	Anne Grahl Layara Akemi Abiko Shin Isogai Timothy Sharpe Stephan Grzesiek
author_sort	Anne Grahl
title	A high-resolution description of β1-adrenergic receptor functional dynamics and allosteric coupling from backbone NMR
title_short	A high-resolution description of β1-adrenergic receptor functional dynamics and allosteric coupling from backbone NMR
title_full	A high-resolution description of β1-adrenergic receptor functional dynamics and allosteric coupling from backbone NMR
title_fullStr	A high-resolution description of β1-adrenergic receptor functional dynamics and allosteric coupling from backbone NMR
title_full_unstemmed	A high-resolution description of β1-adrenergic receptor functional dynamics and allosteric coupling from backbone NMR
title_sort	high-resolution description of β1-adrenergic receptor functional dynamics and allosteric coupling from backbone nmr
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8bb35a77f6744d2dbe67f65cb91afeaf
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A high-resolution description of β1-adrenergic receptor functional dynamics and allosteric coupling from backbone NMR

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