Temporal variability of antibiotics fluxes in wastewater and contribution from hospitals.

Significant quantities of antibiotics are used in all parts of the globe to treat diseases with bacterial origins. After ingestion, antibiotics are excreted by the patient and transmitted in due course to the aquatic environment. This study examined temporal fluctuations (monthly time scale) in anti...

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Autores principales:	Sylvain Coutu, Luca Rossi, D A Barry, Serge Rudaz, Nathalie Vernaz
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8bb3615ca98b4e55b7f7bb687613f670
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spelling	oai:doaj.org-article:8bb3615ca98b4e55b7f7bb687613f6702021-11-18T08:02:18ZTemporal variability of antibiotics fluxes in wastewater and contribution from hospitals.1932-620310.1371/journal.pone.0053592https://doaj.org/article/8bb3615ca98b4e55b7f7bb687613f6702013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23320096/?tool=EBIhttps://doaj.org/toc/1932-6203Significant quantities of antibiotics are used in all parts of the globe to treat diseases with bacterial origins. After ingestion, antibiotics are excreted by the patient and transmitted in due course to the aquatic environment. This study examined temporal fluctuations (monthly time scale) in antibiotic sources (ambulatory sales and data from a hospital dispensary) for Lausanne, Switzerland. Source variability (i.e., antibiotic consumption, monthly data for 2006-2010) were examined in detail for nine antibiotics--azithromycin, ciprofloxacin, clarithromycin, clindamycin, metronidazole, norfloxacin, ofloxacin, sulfamethoxazole and trimethoprim, from which two main conclusions were reached. First, some substances--azithromycin, clarithromycin, ciprofloxacin--displayed high seasonality in their consumption, with the winter peak being up to three times higher than the summer minimum. This seasonality in consumption resulted in seasonality in Predicted Environmental Concentrations (PECs). In addition, the seasonality in PECs was also influenced by that in the base wastewater flow. Second, the contribution of hospitals to the total load of antibiotics reaching the Lausanne Wastewater Treatment Plant (WTP) fluctuated markedly on a monthly time scale, but with no seasonal pattern detected. That is, there was no connection between fluctuations in ambulatory and hospital consumption for the substances investigated.Sylvain CoutuLuca RossiD A BarrySerge RudazNathalie VernazPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 1, p e53592 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sylvain Coutu Luca Rossi D A Barry Serge Rudaz Nathalie Vernaz Temporal variability of antibiotics fluxes in wastewater and contribution from hospitals.
description	Significant quantities of antibiotics are used in all parts of the globe to treat diseases with bacterial origins. After ingestion, antibiotics are excreted by the patient and transmitted in due course to the aquatic environment. This study examined temporal fluctuations (monthly time scale) in antibiotic sources (ambulatory sales and data from a hospital dispensary) for Lausanne, Switzerland. Source variability (i.e., antibiotic consumption, monthly data for 2006-2010) were examined in detail for nine antibiotics--azithromycin, ciprofloxacin, clarithromycin, clindamycin, metronidazole, norfloxacin, ofloxacin, sulfamethoxazole and trimethoprim, from which two main conclusions were reached. First, some substances--azithromycin, clarithromycin, ciprofloxacin--displayed high seasonality in their consumption, with the winter peak being up to three times higher than the summer minimum. This seasonality in consumption resulted in seasonality in Predicted Environmental Concentrations (PECs). In addition, the seasonality in PECs was also influenced by that in the base wastewater flow. Second, the contribution of hospitals to the total load of antibiotics reaching the Lausanne Wastewater Treatment Plant (WTP) fluctuated markedly on a monthly time scale, but with no seasonal pattern detected. That is, there was no connection between fluctuations in ambulatory and hospital consumption for the substances investigated.
format	article
author	Sylvain Coutu Luca Rossi D A Barry Serge Rudaz Nathalie Vernaz
author_facet	Sylvain Coutu Luca Rossi D A Barry Serge Rudaz Nathalie Vernaz
author_sort	Sylvain Coutu
title	Temporal variability of antibiotics fluxes in wastewater and contribution from hospitals.
title_short	Temporal variability of antibiotics fluxes in wastewater and contribution from hospitals.
title_full	Temporal variability of antibiotics fluxes in wastewater and contribution from hospitals.
title_fullStr	Temporal variability of antibiotics fluxes in wastewater and contribution from hospitals.
title_full_unstemmed	Temporal variability of antibiotics fluxes in wastewater and contribution from hospitals.
title_sort	temporal variability of antibiotics fluxes in wastewater and contribution from hospitals.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/8bb3615ca98b4e55b7f7bb687613f670
work_keys_str_mv	AT sylvaincoutu temporalvariabilityofantibioticsfluxesinwastewaterandcontributionfromhospitals AT lucarossi temporalvariabilityofantibioticsfluxesinwastewaterandcontributionfromhospitals AT dabarry temporalvariabilityofantibioticsfluxesinwastewaterandcontributionfromhospitals AT sergerudaz temporalvariabilityofantibioticsfluxesinwastewaterandcontributionfromhospitals AT nathalievernaz temporalvariabilityofantibioticsfluxesinwastewaterandcontributionfromhospitals
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Temporal variability of antibiotics fluxes in wastewater and contribution from hospitals.

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