Outcome analysis of early surgery and conservative treatment in neonates and infants with severe hydronephrosis

Objective The treatment strategy and timing of ureteropelvic junction obstruction (UPJO) in infants remain controversial. This study aimed to compare the effect of early surgical treatment (EST) and conservative treatment (CT) on neonates and infants with UPJO and their recovery of renal function an...

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Autores principales:	Qi-Fei Deng, Han Chu, Bo Peng, Xiang Liu, Yong-Sheng Cao
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8bb493c89a6d417dba8f7f972b46a3f9
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spelling	oai:doaj.org-article:8bb493c89a6d417dba8f7f972b46a3f92021-11-15T00:33:18ZOutcome analysis of early surgery and conservative treatment in neonates and infants with severe hydronephrosis1473-230010.1177/03000605211057866https://doaj.org/article/8bb493c89a6d417dba8f7f972b46a3f92021-11-01T00:00:00Zhttps://doi.org/10.1177/03000605211057866https://doaj.org/toc/1473-2300Objective The treatment strategy and timing of ureteropelvic junction obstruction (UPJO) in infants remain controversial. This study aimed to compare the effect of early surgical treatment (EST) and conservative treatment (CT) on neonates and infants with UPJO and their recovery of renal function and morphology. Methods Eighty neonates and infants with severe hydronephrosis were enrolled in this study. They received early pyeloureteroplasty or CT. Diethylenetriamine pentaacetate was used to assess renal function. Results There were no significant differences in renal function or renal indices at baseline between the two groups. At 3 and 6 months of follow-up, the anteroposterior diameter of the renal pelvis and the Society of Fetal Urology grade in the EST surgery group were significantly lower compared with those at baseline. The thickness of the renal cortex was greater in the EST group than in the CT group at 3 and 6 months of follow-up. After follow-up for 6 months, renal function in the EST group was significantly better than that in the CT group. Conclusion EST accelerates the recovery of renal morphological and functional indices in neonates and infants with severe hydronephrosis.Qi-Fei DengHan ChuBo PengXiang LiuYong-Sheng CaoSAGE PublishingarticleMedicine (General)R5-920ENJournal of International Medical Research, Vol 49 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Qi-Fei Deng Han Chu Bo Peng Xiang Liu Yong-Sheng Cao Outcome analysis of early surgery and conservative treatment in neonates and infants with severe hydronephrosis
description	Objective The treatment strategy and timing of ureteropelvic junction obstruction (UPJO) in infants remain controversial. This study aimed to compare the effect of early surgical treatment (EST) and conservative treatment (CT) on neonates and infants with UPJO and their recovery of renal function and morphology. Methods Eighty neonates and infants with severe hydronephrosis were enrolled in this study. They received early pyeloureteroplasty or CT. Diethylenetriamine pentaacetate was used to assess renal function. Results There were no significant differences in renal function or renal indices at baseline between the two groups. At 3 and 6 months of follow-up, the anteroposterior diameter of the renal pelvis and the Society of Fetal Urology grade in the EST surgery group were significantly lower compared with those at baseline. The thickness of the renal cortex was greater in the EST group than in the CT group at 3 and 6 months of follow-up. After follow-up for 6 months, renal function in the EST group was significantly better than that in the CT group. Conclusion EST accelerates the recovery of renal morphological and functional indices in neonates and infants with severe hydronephrosis.
format	article
author	Qi-Fei Deng Han Chu Bo Peng Xiang Liu Yong-Sheng Cao
author_facet	Qi-Fei Deng Han Chu Bo Peng Xiang Liu Yong-Sheng Cao
author_sort	Qi-Fei Deng
title	Outcome analysis of early surgery and conservative treatment in neonates and infants with severe hydronephrosis
title_short	Outcome analysis of early surgery and conservative treatment in neonates and infants with severe hydronephrosis
title_full	Outcome analysis of early surgery and conservative treatment in neonates and infants with severe hydronephrosis
title_fullStr	Outcome analysis of early surgery and conservative treatment in neonates and infants with severe hydronephrosis
title_full_unstemmed	Outcome analysis of early surgery and conservative treatment in neonates and infants with severe hydronephrosis
title_sort	outcome analysis of early surgery and conservative treatment in neonates and infants with severe hydronephrosis
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/8bb493c89a6d417dba8f7f972b46a3f9
work_keys_str_mv	AT qifeideng outcomeanalysisofearlysurgeryandconservativetreatmentinneonatesandinfantswithseverehydronephrosis AT hanchu outcomeanalysisofearlysurgeryandconservativetreatmentinneonatesandinfantswithseverehydronephrosis AT bopeng outcomeanalysisofearlysurgeryandconservativetreatmentinneonatesandinfantswithseverehydronephrosis AT xiangliu outcomeanalysisofearlysurgeryandconservativetreatmentinneonatesandinfantswithseverehydronephrosis AT yongshengcao outcomeanalysisofearlysurgeryandconservativetreatmentinneonatesandinfantswithseverehydronephrosis
_version_	1718428995872096256

Outcome analysis of early surgery and conservative treatment in neonates and infants with severe hydronephrosis

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