Association between maternal exposure to phthalates and lower language ability in offspring derived from hair metabolome analysis

Abstract The fetus undergoes a crucial period of neurodevelopment in utero. The maternal hair metabolome provides an integrated record of the metabolic state of the mother prior to, and during pregnancy. We investigated whether variation in the maternal hair metabolome was associated with neurodevel...

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Autores principales:	Beatrix Jones, Ting-Li Han, Thibaut Delplancke, Elizabeth J. McKenzie, Jamie V. de Seymour, Mei Chien Chua, Kok Hian Tan, Philip N. Baker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8bb50e440bd5422db8e1f5b38e623698
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spelling	oai:doaj.org-article:8bb50e440bd5422db8e1f5b38e6236982021-12-02T16:07:50ZAssociation between maternal exposure to phthalates and lower language ability in offspring derived from hair metabolome analysis10.1038/s41598-018-24936-52045-2322https://doaj.org/article/8bb50e440bd5422db8e1f5b38e6236982018-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-24936-5https://doaj.org/toc/2045-2322Abstract The fetus undergoes a crucial period of neurodevelopment in utero. The maternal hair metabolome provides an integrated record of the metabolic state of the mother prior to, and during pregnancy. We investigated whether variation in the maternal hair metabolome was associated with neurodevelopmental differences across infants. Maternal hair samples and infant neurocognitive assessments (using the Bayley III Scales of Infant Development at 24 months) were obtained for 373 infant-mother dyads between 26–28 weeks’ gestation from the Growing Up in Singapore Towards Healthy Outcomes cohort. The hair metabolome was analysed using gas chromatography-mass spectrometry. Intensity measurements were obtained for 276 compounds. After controlling for maternal education, ethnicity, and infant sex, associations between metabolites and expressive language skills were detected, but not for receptive language, cognitive or motor skills. The results confirm previous research associating higher levels of phthalates with lower language ability. In addition, scores were positively associated with a cluster of compounds, including adipic acid and medium-chain fatty acids. The data support associations between the maternal hair metabolome and neurodevelopmental processes of the fetus. The association between phthalates and lower language ability highlights a modifiable risk factor that warrants further investigation.Beatrix JonesTing-Li HanThibaut DelplanckeElizabeth J. McKenzieJamie V. de SeymourMei Chien ChuaKok Hian TanPhilip N. BakerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Beatrix Jones Ting-Li Han Thibaut Delplancke Elizabeth J. McKenzie Jamie V. de Seymour Mei Chien Chua Kok Hian Tan Philip N. Baker Association between maternal exposure to phthalates and lower language ability in offspring derived from hair metabolome analysis
description	Abstract The fetus undergoes a crucial period of neurodevelopment in utero. The maternal hair metabolome provides an integrated record of the metabolic state of the mother prior to, and during pregnancy. We investigated whether variation in the maternal hair metabolome was associated with neurodevelopmental differences across infants. Maternal hair samples and infant neurocognitive assessments (using the Bayley III Scales of Infant Development at 24 months) were obtained for 373 infant-mother dyads between 26–28 weeks’ gestation from the Growing Up in Singapore Towards Healthy Outcomes cohort. The hair metabolome was analysed using gas chromatography-mass spectrometry. Intensity measurements were obtained for 276 compounds. After controlling for maternal education, ethnicity, and infant sex, associations between metabolites and expressive language skills were detected, but not for receptive language, cognitive or motor skills. The results confirm previous research associating higher levels of phthalates with lower language ability. In addition, scores were positively associated with a cluster of compounds, including adipic acid and medium-chain fatty acids. The data support associations between the maternal hair metabolome and neurodevelopmental processes of the fetus. The association between phthalates and lower language ability highlights a modifiable risk factor that warrants further investigation.
format	article
author	Beatrix Jones Ting-Li Han Thibaut Delplancke Elizabeth J. McKenzie Jamie V. de Seymour Mei Chien Chua Kok Hian Tan Philip N. Baker
author_facet	Beatrix Jones Ting-Li Han Thibaut Delplancke Elizabeth J. McKenzie Jamie V. de Seymour Mei Chien Chua Kok Hian Tan Philip N. Baker
author_sort	Beatrix Jones
title	Association between maternal exposure to phthalates and lower language ability in offspring derived from hair metabolome analysis
title_short	Association between maternal exposure to phthalates and lower language ability in offspring derived from hair metabolome analysis
title_full	Association between maternal exposure to phthalates and lower language ability in offspring derived from hair metabolome analysis
title_fullStr	Association between maternal exposure to phthalates and lower language ability in offspring derived from hair metabolome analysis
title_full_unstemmed	Association between maternal exposure to phthalates and lower language ability in offspring derived from hair metabolome analysis
title_sort	association between maternal exposure to phthalates and lower language ability in offspring derived from hair metabolome analysis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/8bb50e440bd5422db8e1f5b38e623698
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Association between maternal exposure to phthalates and lower language ability in offspring derived from hair metabolome analysis

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