Surgical outcomes after collagenase Clostridium histolyticum failure in patients with Peyronie’s disease in a multicenter clinical study

Abstract In the present study we aimed to investigate the surgical outcomes of patients with persistent penile curvature (PC) after Collagenase Clostridium histolyticum (CCH) intraplaque injections. Data from 90 patients with persistent PC after CCH in a multicentre study from 6 andrological centres...

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Autores principales:	Andrea Cocci, David Ralph, Rados Djinovic, Georgios Hatzichristodoulou, Girolamo Morelli, Andrea Salonia, Paolo Capogrosso, Andrea Romano, Gianmartin Cito, Fabrizio Di Maida, Esaú Fernández-Pascual, Javier Romero-Otero, Paulo Egydio, Marco Falcone, Mirko Preto, Giovanni Chiriacò, Jack Beck, Maarten Albersen, Suks Minhas, Giovanni Cacciamani, Juan Ignacio Martinez Salamanca, Nicola Mondani, Andrea Minervini, Giorgio Ivan Russo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8bb57d36d36b4aa39e0d517e5200f323
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spelling	oai:doaj.org-article:8bb57d36d36b4aa39e0d517e5200f3232021-12-02T11:46:06ZSurgical outcomes after collagenase Clostridium histolyticum failure in patients with Peyronie’s disease in a multicenter clinical study10.1038/s41598-020-80551-32045-2322https://doaj.org/article/8bb57d36d36b4aa39e0d517e5200f3232021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80551-3https://doaj.org/toc/2045-2322Abstract In the present study we aimed to investigate the surgical outcomes of patients with persistent penile curvature (PC) after Collagenase Clostridium histolyticum (CCH) intraplaque injections. Data from 90 patients with persistent PC after CCH in a multicentre study from 6 andrological centres were retrospectively reviewed. Three standardized surgical techniques were performed. Group 1: plaque incision grafting (PIG) with penile prosthesis implant (PPI); Group 2: PIG without PPI; Group 3: Nesbit technique. Hospital stay, operative time, postoperative complications and PC persistency/recurrence (> 20°) were evaluated. Overall satisfaction and functional outcomes were assessed through International Index of Erectile Function-Erectile Function (IIEF-EF), Peyronie’s Disease Questionnaire (PDQ), Female Sexual Function Index (FSFI) administered pre and 3 months postoperatively. Of all, 25 (27.8%) patients received grafting procedure + PPI (Group 1), 18 (20.0%) patients belonged to Group 2, and 47 (52.2%) to Group 3. Bovine pericardium graft and collagen fleece have been used in in 22 (51.2%) and 21 (48.8%) patients, respectively. Median penile length after surgery was 13.0 cm (IQR 12.0–15.0). After surgery, Group 1 showed higher increase in penile length after surgery and better improvements in terms of PDQ-PS. In contrast, both IIEF-EF and FSFI scores did not differ among groups. Overall, 86 (95.6%) did not report any complication. 4 (4.4%) patients had PC recurrence; of those, 2 (8.0%), 1 (5.6%) and 1 (2.1%) cases were observed in Group 1, Group 2 and Group 3, respectively. In case of persistent PC after CCH, surgical correction by grafting with or without concomitant PPI or Nesbit technique emerged as a technically feasible, effective and safe procedure, with no significant postoperative complications.Andrea CocciDavid RalphRados DjinovicGeorgios HatzichristodoulouGirolamo MorelliAndrea SaloniaPaolo CapogrossoAndrea RomanoGianmartin CitoFabrizio Di MaidaEsaú Fernández-PascualJavier Romero-OteroPaulo EgydioMarco FalconeMirko PretoGiovanni ChiriacòJack BeckMaarten AlbersenSuks MinhasGiovanni CacciamaniJuan Ignacio Martinez SalamancaNicola MondaniAndrea MinerviniGiorgio Ivan RussoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Andrea Cocci David Ralph Rados Djinovic Georgios Hatzichristodoulou Girolamo Morelli Andrea Salonia Paolo Capogrosso Andrea Romano Gianmartin Cito Fabrizio Di Maida Esaú Fernández-Pascual Javier Romero-Otero Paulo Egydio Marco Falcone Mirko Preto Giovanni Chiriacò Jack Beck Maarten Albersen Suks Minhas Giovanni Cacciamani Juan Ignacio Martinez Salamanca Nicola Mondani Andrea Minervini Giorgio Ivan Russo Surgical outcomes after collagenase Clostridium histolyticum failure in patients with Peyronie’s disease in a multicenter clinical study
description	Abstract In the present study we aimed to investigate the surgical outcomes of patients with persistent penile curvature (PC) after Collagenase Clostridium histolyticum (CCH) intraplaque injections. Data from 90 patients with persistent PC after CCH in a multicentre study from 6 andrological centres were retrospectively reviewed. Three standardized surgical techniques were performed. Group 1: plaque incision grafting (PIG) with penile prosthesis implant (PPI); Group 2: PIG without PPI; Group 3: Nesbit technique. Hospital stay, operative time, postoperative complications and PC persistency/recurrence (> 20°) were evaluated. Overall satisfaction and functional outcomes were assessed through International Index of Erectile Function-Erectile Function (IIEF-EF), Peyronie’s Disease Questionnaire (PDQ), Female Sexual Function Index (FSFI) administered pre and 3 months postoperatively. Of all, 25 (27.8%) patients received grafting procedure + PPI (Group 1), 18 (20.0%) patients belonged to Group 2, and 47 (52.2%) to Group 3. Bovine pericardium graft and collagen fleece have been used in in 22 (51.2%) and 21 (48.8%) patients, respectively. Median penile length after surgery was 13.0 cm (IQR 12.0–15.0). After surgery, Group 1 showed higher increase in penile length after surgery and better improvements in terms of PDQ-PS. In contrast, both IIEF-EF and FSFI scores did not differ among groups. Overall, 86 (95.6%) did not report any complication. 4 (4.4%) patients had PC recurrence; of those, 2 (8.0%), 1 (5.6%) and 1 (2.1%) cases were observed in Group 1, Group 2 and Group 3, respectively. In case of persistent PC after CCH, surgical correction by grafting with or without concomitant PPI or Nesbit technique emerged as a technically feasible, effective and safe procedure, with no significant postoperative complications.
format	article
author	Andrea Cocci David Ralph Rados Djinovic Georgios Hatzichristodoulou Girolamo Morelli Andrea Salonia Paolo Capogrosso Andrea Romano Gianmartin Cito Fabrizio Di Maida Esaú Fernández-Pascual Javier Romero-Otero Paulo Egydio Marco Falcone Mirko Preto Giovanni Chiriacò Jack Beck Maarten Albersen Suks Minhas Giovanni Cacciamani Juan Ignacio Martinez Salamanca Nicola Mondani Andrea Minervini Giorgio Ivan Russo
author_facet	Andrea Cocci David Ralph Rados Djinovic Georgios Hatzichristodoulou Girolamo Morelli Andrea Salonia Paolo Capogrosso Andrea Romano Gianmartin Cito Fabrizio Di Maida Esaú Fernández-Pascual Javier Romero-Otero Paulo Egydio Marco Falcone Mirko Preto Giovanni Chiriacò Jack Beck Maarten Albersen Suks Minhas Giovanni Cacciamani Juan Ignacio Martinez Salamanca Nicola Mondani Andrea Minervini Giorgio Ivan Russo
author_sort	Andrea Cocci
title	Surgical outcomes after collagenase Clostridium histolyticum failure in patients with Peyronie’s disease in a multicenter clinical study
title_short	Surgical outcomes after collagenase Clostridium histolyticum failure in patients with Peyronie’s disease in a multicenter clinical study
title_full	Surgical outcomes after collagenase Clostridium histolyticum failure in patients with Peyronie’s disease in a multicenter clinical study
title_fullStr	Surgical outcomes after collagenase Clostridium histolyticum failure in patients with Peyronie’s disease in a multicenter clinical study
title_full_unstemmed	Surgical outcomes after collagenase Clostridium histolyticum failure in patients with Peyronie’s disease in a multicenter clinical study
title_sort	surgical outcomes after collagenase clostridium histolyticum failure in patients with peyronie’s disease in a multicenter clinical study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8bb57d36d36b4aa39e0d517e5200f323
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Surgical outcomes after collagenase Clostridium histolyticum failure in patients with Peyronie’s disease in a multicenter clinical study

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