Assay to visualize specific protein oxidation reveals spatio-temporal regulation of SHP2

Protein-tyrosine phosphatases (PTPs) are thought to be major targets of receptor-activated reactive oxygen species (ROS). Here the authors describe a method that allows the localized visualization of oxidized intermediates of PTPs inside cells during signaling, and provide support for the “redoxosom...

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Autores principales:	Ryouhei Tsutsumi, Jana Harizanova, Rabea Stockert, Katrin Schröder, Philippe I. H. Bastiaens, Benjamin G. Neel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8bb5ae328a9f42468f14ce5e3ac5290f
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spelling	oai:doaj.org-article:8bb5ae328a9f42468f14ce5e3ac5290f2021-12-02T15:38:55ZAssay to visualize specific protein oxidation reveals spatio-temporal regulation of SHP210.1038/s41467-017-00503-w2041-1723https://doaj.org/article/8bb5ae328a9f42468f14ce5e3ac5290f2017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00503-whttps://doaj.org/toc/2041-1723Protein-tyrosine phosphatases (PTPs) are thought to be major targets of receptor-activated reactive oxygen species (ROS). Here the authors describe a method that allows the localized visualization of oxidized intermediates of PTPs inside cells during signaling, and provide support for the “redoxosome” model.Ryouhei TsutsumiJana HarizanovaRabea StockertKatrin SchröderPhilippe I. H. BastiaensBenjamin G. NeelNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ryouhei Tsutsumi Jana Harizanova Rabea Stockert Katrin Schröder Philippe I. H. Bastiaens Benjamin G. Neel Assay to visualize specific protein oxidation reveals spatio-temporal regulation of SHP2
description	Protein-tyrosine phosphatases (PTPs) are thought to be major targets of receptor-activated reactive oxygen species (ROS). Here the authors describe a method that allows the localized visualization of oxidized intermediates of PTPs inside cells during signaling, and provide support for the “redoxosome” model.
format	article
author	Ryouhei Tsutsumi Jana Harizanova Rabea Stockert Katrin Schröder Philippe I. H. Bastiaens Benjamin G. Neel
author_facet	Ryouhei Tsutsumi Jana Harizanova Rabea Stockert Katrin Schröder Philippe I. H. Bastiaens Benjamin G. Neel
author_sort	Ryouhei Tsutsumi
title	Assay to visualize specific protein oxidation reveals spatio-temporal regulation of SHP2
title_short	Assay to visualize specific protein oxidation reveals spatio-temporal regulation of SHP2
title_full	Assay to visualize specific protein oxidation reveals spatio-temporal regulation of SHP2
title_fullStr	Assay to visualize specific protein oxidation reveals spatio-temporal regulation of SHP2
title_full_unstemmed	Assay to visualize specific protein oxidation reveals spatio-temporal regulation of SHP2
title_sort	assay to visualize specific protein oxidation reveals spatio-temporal regulation of shp2
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8bb5ae328a9f42468f14ce5e3ac5290f
work_keys_str_mv	AT ryouheitsutsumi assaytovisualizespecificproteinoxidationrevealsspatiotemporalregulationofshp2 AT janaharizanova assaytovisualizespecificproteinoxidationrevealsspatiotemporalregulationofshp2 AT rabeastockert assaytovisualizespecificproteinoxidationrevealsspatiotemporalregulationofshp2 AT katrinschroder assaytovisualizespecificproteinoxidationrevealsspatiotemporalregulationofshp2 AT philippeihbastiaens assaytovisualizespecificproteinoxidationrevealsspatiotemporalregulationofshp2 AT benjamingneel assaytovisualizespecificproteinoxidationrevealsspatiotemporalregulationofshp2
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Assay to visualize specific protein oxidation reveals spatio-temporal regulation of SHP2

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