Assay to visualize specific protein oxidation reveals spatio-temporal regulation of SHP2

Protein-tyrosine phosphatases (PTPs) are thought to be major targets of receptor-activated reactive oxygen species (ROS). Here the authors describe a method that allows the localized visualization of oxidized intermediates of PTPs inside cells during signaling, and provide support for the “redoxosom...

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Autores principales: Ryouhei Tsutsumi, Jana Harizanova, Rabea Stockert, Katrin Schröder, Philippe I. H. Bastiaens, Benjamin G. Neel
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/8bb5ae328a9f42468f14ce5e3ac5290f
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