Assay to visualize specific protein oxidation reveals spatio-temporal regulation of SHP2
Protein-tyrosine phosphatases (PTPs) are thought to be major targets of receptor-activated reactive oxygen species (ROS). Here the authors describe a method that allows the localized visualization of oxidized intermediates of PTPs inside cells during signaling, and provide support for the “redoxosom...
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Autores principales: | Ryouhei Tsutsumi, Jana Harizanova, Rabea Stockert, Katrin Schröder, Philippe I. H. Bastiaens, Benjamin G. Neel |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2017
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Materias: | |
Acceso en línea: | https://doaj.org/article/8bb5ae328a9f42468f14ce5e3ac5290f |
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