Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension

PIEZO1 is a mechanosensitive ion channel, but the mechanism of force transduction is unknown. Here Cox and Bae et al.disrupt the cortical cytoskeleton in HEK293 cells to show that PIEZO1 is gated directly by membrane tension.

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Autores principales:	Charles D. Cox, Chilman Bae, Lynn Ziegler, Silas Hartley, Vesna Nikolova-Krstevski, Paul R. Rohde, Chai-Ann Ng, Frederick Sachs, Philip A. Gottlieb, Boris Martinac
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8bb6428e3a354f2a80b77e5eb08f7827
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spelling	oai:doaj.org-article:8bb6428e3a354f2a80b77e5eb08f78272021-12-02T14:39:32ZRemoval of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension10.1038/ncomms103662041-1723https://doaj.org/article/8bb6428e3a354f2a80b77e5eb08f78272016-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms10366https://doaj.org/toc/2041-1723PIEZO1 is a mechanosensitive ion channel, but the mechanism of force transduction is unknown. Here Cox and Bae et al.disrupt the cortical cytoskeleton in HEK293 cells to show that PIEZO1 is gated directly by membrane tension.Charles D. CoxChilman BaeLynn ZieglerSilas HartleyVesna Nikolova-KrstevskiPaul R. RohdeChai-Ann NgFrederick SachsPhilip A. GottliebBoris MartinacNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Charles D. Cox Chilman Bae Lynn Ziegler Silas Hartley Vesna Nikolova-Krstevski Paul R. Rohde Chai-Ann Ng Frederick Sachs Philip A. Gottlieb Boris Martinac Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension
description	PIEZO1 is a mechanosensitive ion channel, but the mechanism of force transduction is unknown. Here Cox and Bae et al.disrupt the cortical cytoskeleton in HEK293 cells to show that PIEZO1 is gated directly by membrane tension.
format	article
author	Charles D. Cox Chilman Bae Lynn Ziegler Silas Hartley Vesna Nikolova-Krstevski Paul R. Rohde Chai-Ann Ng Frederick Sachs Philip A. Gottlieb Boris Martinac
author_facet	Charles D. Cox Chilman Bae Lynn Ziegler Silas Hartley Vesna Nikolova-Krstevski Paul R. Rohde Chai-Ann Ng Frederick Sachs Philip A. Gottlieb Boris Martinac
author_sort	Charles D. Cox
title	Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension
title_short	Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension
title_full	Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension
title_fullStr	Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension
title_full_unstemmed	Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension
title_sort	removal of the mechanoprotective influence of the cytoskeleton reveals piezo1 is gated by bilayer tension
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/8bb6428e3a354f2a80b77e5eb08f7827
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Removal of the mechanoprotective influence of the cytoskeleton reveals PIEZO1 is gated by bilayer tension

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