Design of multi-scale protein complexes by hierarchical building block fusion

De novo design of self-assembling protein nanostructures and materials is of significant interest, however design of complex, multi-component assemblies is challenging. Here, the authors present a stepwise hierarchical approach to build such assemblies using helical repeat and helical bundle protein...

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Autores principales:	Yang Hsia, Rubul Mout, William Sheffler, Natasha I. Edman, Ivan Vulovic, Young-Jun Park, Rachel L. Redler, Matthew J. Bick, Asim K. Bera, Alexis Courbet, Alex Kang, T. J. Brunette, Una Nattermann, Evelyn Tsai, Ayesha Saleem, Cameron M. Chow, Damian Ekiert, Gira Bhabha, David Veesler, David Baker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8bb80e33cedb4e58856a97a798a217fd
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spelling	oai:doaj.org-article:8bb80e33cedb4e58856a97a798a217fd2021-12-02T15:51:07ZDesign of multi-scale protein complexes by hierarchical building block fusion10.1038/s41467-021-22276-z2041-1723https://doaj.org/article/8bb80e33cedb4e58856a97a798a217fd2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22276-zhttps://doaj.org/toc/2041-1723De novo design of self-assembling protein nanostructures and materials is of significant interest, however design of complex, multi-component assemblies is challenging. Here, the authors present a stepwise hierarchical approach to build such assemblies using helical repeat and helical bundle proteins as building blocks, and provide an in-depth structural characterization of the resulting assemblies.Yang HsiaRubul MoutWilliam ShefflerNatasha I. EdmanIvan VulovicYoung-Jun ParkRachel L. RedlerMatthew J. BickAsim K. BeraAlexis CourbetAlex KangT. J. BrunetteUna NattermannEvelyn TsaiAyesha SaleemCameron M. ChowDamian EkiertGira BhabhaDavid VeeslerDavid BakerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yang Hsia Rubul Mout William Sheffler Natasha I. Edman Ivan Vulovic Young-Jun Park Rachel L. Redler Matthew J. Bick Asim K. Bera Alexis Courbet Alex Kang T. J. Brunette Una Nattermann Evelyn Tsai Ayesha Saleem Cameron M. Chow Damian Ekiert Gira Bhabha David Veesler David Baker Design of multi-scale protein complexes by hierarchical building block fusion
description	De novo design of self-assembling protein nanostructures and materials is of significant interest, however design of complex, multi-component assemblies is challenging. Here, the authors present a stepwise hierarchical approach to build such assemblies using helical repeat and helical bundle proteins as building blocks, and provide an in-depth structural characterization of the resulting assemblies.
format	article
author	Yang Hsia Rubul Mout William Sheffler Natasha I. Edman Ivan Vulovic Young-Jun Park Rachel L. Redler Matthew J. Bick Asim K. Bera Alexis Courbet Alex Kang T. J. Brunette Una Nattermann Evelyn Tsai Ayesha Saleem Cameron M. Chow Damian Ekiert Gira Bhabha David Veesler David Baker
author_facet	Yang Hsia Rubul Mout William Sheffler Natasha I. Edman Ivan Vulovic Young-Jun Park Rachel L. Redler Matthew J. Bick Asim K. Bera Alexis Courbet Alex Kang T. J. Brunette Una Nattermann Evelyn Tsai Ayesha Saleem Cameron M. Chow Damian Ekiert Gira Bhabha David Veesler David Baker
author_sort	Yang Hsia
title	Design of multi-scale protein complexes by hierarchical building block fusion
title_short	Design of multi-scale protein complexes by hierarchical building block fusion
title_full	Design of multi-scale protein complexes by hierarchical building block fusion
title_fullStr	Design of multi-scale protein complexes by hierarchical building block fusion
title_full_unstemmed	Design of multi-scale protein complexes by hierarchical building block fusion
title_sort	design of multi-scale protein complexes by hierarchical building block fusion
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8bb80e33cedb4e58856a97a798a217fd
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Design of multi-scale protein complexes by hierarchical building block fusion

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