CUT&Tag for efficient epigenomic profiling of small samples and single cells

Understanding gene regulation will require mapping specific chromain features in a small number of cells at high resolution. Here the authors describe CUT&Tag, which uses antibody-mediated tethering of Tn5 transposase to a chromatin protein to generate high resolution libraries.

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Autores principales:	Hatice S. Kaya-Okur, Steven J. Wu, Christine A. Codomo, Erica S. Pledger, Terri D. Bryson, Jorja G. Henikoff, Kami Ahmad, Steven Henikoff
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8bb94c477325463b8190bc5a81b1c143
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spelling	oai:doaj.org-article:8bb94c477325463b8190bc5a81b1c1432021-12-02T16:58:17ZCUT&Tag for efficient epigenomic profiling of small samples and single cells10.1038/s41467-019-09982-52041-1723https://doaj.org/article/8bb94c477325463b8190bc5a81b1c1432019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09982-5https://doaj.org/toc/2041-1723Understanding gene regulation will require mapping specific chromain features in a small number of cells at high resolution. Here the authors describe CUT&Tag, which uses antibody-mediated tethering of Tn5 transposase to a chromatin protein to generate high resolution libraries.Hatice S. Kaya-OkurSteven J. WuChristine A. CodomoErica S. PledgerTerri D. BrysonJorja G. HenikoffKami AhmadSteven HenikoffNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hatice S. Kaya-Okur Steven J. Wu Christine A. Codomo Erica S. Pledger Terri D. Bryson Jorja G. Henikoff Kami Ahmad Steven Henikoff CUT&Tag for efficient epigenomic profiling of small samples and single cells
description	Understanding gene regulation will require mapping specific chromain features in a small number of cells at high resolution. Here the authors describe CUT&Tag, which uses antibody-mediated tethering of Tn5 transposase to a chromatin protein to generate high resolution libraries.
format	article
author	Hatice S. Kaya-Okur Steven J. Wu Christine A. Codomo Erica S. Pledger Terri D. Bryson Jorja G. Henikoff Kami Ahmad Steven Henikoff
author_facet	Hatice S. Kaya-Okur Steven J. Wu Christine A. Codomo Erica S. Pledger Terri D. Bryson Jorja G. Henikoff Kami Ahmad Steven Henikoff
author_sort	Hatice S. Kaya-Okur
title	CUT&Tag for efficient epigenomic profiling of small samples and single cells
title_short	CUT&Tag for efficient epigenomic profiling of small samples and single cells
title_full	CUT&Tag for efficient epigenomic profiling of small samples and single cells
title_fullStr	CUT&Tag for efficient epigenomic profiling of small samples and single cells
title_full_unstemmed	CUT&Tag for efficient epigenomic profiling of small samples and single cells
title_sort	cut&tag for efficient epigenomic profiling of small samples and single cells
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/8bb94c477325463b8190bc5a81b1c143
work_keys_str_mv	AT haticeskayaokur cuttagforefficientepigenomicprofilingofsmallsamplesandsinglecells AT stevenjwu cuttagforefficientepigenomicprofilingofsmallsamplesandsinglecells AT christineacodomo cuttagforefficientepigenomicprofilingofsmallsamplesandsinglecells AT ericaspledger cuttagforefficientepigenomicprofilingofsmallsamplesandsinglecells AT terridbryson cuttagforefficientepigenomicprofilingofsmallsamplesandsinglecells AT jorjaghenikoff cuttagforefficientepigenomicprofilingofsmallsamplesandsinglecells AT kamiahmad cuttagforefficientepigenomicprofilingofsmallsamplesandsinglecells AT stevenhenikoff cuttagforefficientepigenomicprofilingofsmallsamplesandsinglecells
_version_	1718382341991170048

CUT&Tag for efficient epigenomic profiling of small samples and single cells

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