Factors Affecting Nodal Status in Breast Cancer

Background: Nodal status in breast cancer [BC] is the most prognostic factor for survival and prognosis, and affects treatment decisions. Nodal status had reciprocal relation with pre- and post-operative factors. All these reflect the crucial importance of nodal status in BC. Aim of the work: Evalu...

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Autores principales:	Diaa Aboelata, Amr Sarhan, Mohammed Abo Mira, Sami Mohammed
Formato:	article
Lenguaje:	EN
Publicado:	Al-Azhar University, Faculty of Medicine (Damietta) 2020
Materias:	axillary evacuation breast cancer lymph nodes adjuvant therapy prognosis Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/8bbeaacc605342e2bcacdf45b42c27d4
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spelling	oai:doaj.org-article:8bbeaacc605342e2bcacdf45b42c27d42021-12-02T13:52:46ZFactors Affecting Nodal Status in Breast Cancer2636-41742682-378010.21608/ijma.2020.24500.1105https://doaj.org/article/8bbeaacc605342e2bcacdf45b42c27d42020-07-01T00:00:00Zhttps://ijma.journals.ekb.eg/article_92262_04c2f90ab42fd684e7610c88af8e6fc3.pdfhttps://doaj.org/toc/2636-4174https://doaj.org/toc/2682-3780Background: Nodal status in breast cancer [BC] is the most prognostic factor for survival and prognosis, and affects treatment decisions. Nodal status had reciprocal relation with pre- and post-operative factors. All these reflect the crucial importance of nodal status in BC. Aim of the work: Evaluation of pre- and post-operative factors related to nodal status in breast cancer. Patients and Methods: The current work included 40 patients with confirmed BC, who had been scheduled for modified radical mastectomy or conservative breast surgery with axillary evacuation. All were assessed in a systematic manner preoperatively. In addition, an intraoperative and post-operative evaluation had been carried out. Postoperative histopathological examination of excised tissues had been done for all specimens. Both intra- and post-surgical complications and factors associated with positive nodal status were documented. Results: The most significant factors associated with high positive nodal status were age (patient ≤ 45 years was significantly associated with increased positive nodes when compared to > 45 years (37.68±35.23 vs 17.66±19.45 respectively), obesity (30.66±27.33 vs 18.49±25.07 nodes for obese and lean individuals respectively)., tumors greater than 2 cm, positivity of the human-epidermal-growth-factor receptor 2 [Her2]/neu, positive lymphovasular invasion, tumors of the upper quadrant, and the type of histopathology. Conclusion: Nodal status affected by pre- and post-surgery factors (e.g., age, obesity, tumor site, tumor size, Her2/neu, lymphovascular invasion and histopathological type of the tumor). Thus, these factors help in planning of the treatment such as the type of surgery, endocrine therapy, radiation therapy and the adjuvant chemotherapy.Diaa AboelataAmr SarhanMohammed Abo MiraSami MohammedAl-Azhar University, Faculty of Medicine (Damietta)articleaxillary evacuationbreast cancerlymph nodesadjuvant therapyprognosisMedicine (General)R5-920ENInternational Journal of Medical Arts, Vol 2, Iss 3, Pp 535-541 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	axillary evacuation breast cancer lymph nodes adjuvant therapy prognosis Medicine (General) R5-920
spellingShingle	axillary evacuation breast cancer lymph nodes adjuvant therapy prognosis Medicine (General) R5-920 Diaa Aboelata Amr Sarhan Mohammed Abo Mira Sami Mohammed Factors Affecting Nodal Status in Breast Cancer
description	Background: Nodal status in breast cancer [BC] is the most prognostic factor for survival and prognosis, and affects treatment decisions. Nodal status had reciprocal relation with pre- and post-operative factors. All these reflect the crucial importance of nodal status in BC. Aim of the work: Evaluation of pre- and post-operative factors related to nodal status in breast cancer. Patients and Methods: The current work included 40 patients with confirmed BC, who had been scheduled for modified radical mastectomy or conservative breast surgery with axillary evacuation. All were assessed in a systematic manner preoperatively. In addition, an intraoperative and post-operative evaluation had been carried out. Postoperative histopathological examination of excised tissues had been done for all specimens. Both intra- and post-surgical complications and factors associated with positive nodal status were documented. Results: The most significant factors associated with high positive nodal status were age (patient ≤ 45 years was significantly associated with increased positive nodes when compared to > 45 years (37.68±35.23 vs 17.66±19.45 respectively), obesity (30.66±27.33 vs 18.49±25.07 nodes for obese and lean individuals respectively)., tumors greater than 2 cm, positivity of the human-epidermal-growth-factor receptor 2 [Her2]/neu, positive lymphovasular invasion, tumors of the upper quadrant, and the type of histopathology. Conclusion: Nodal status affected by pre- and post-surgery factors (e.g., age, obesity, tumor site, tumor size, Her2/neu, lymphovascular invasion and histopathological type of the tumor). Thus, these factors help in planning of the treatment such as the type of surgery, endocrine therapy, radiation therapy and the adjuvant chemotherapy.
format	article
author	Diaa Aboelata Amr Sarhan Mohammed Abo Mira Sami Mohammed
author_facet	Diaa Aboelata Amr Sarhan Mohammed Abo Mira Sami Mohammed
author_sort	Diaa Aboelata
title	Factors Affecting Nodal Status in Breast Cancer
title_short	Factors Affecting Nodal Status in Breast Cancer
title_full	Factors Affecting Nodal Status in Breast Cancer
title_fullStr	Factors Affecting Nodal Status in Breast Cancer
title_full_unstemmed	Factors Affecting Nodal Status in Breast Cancer
title_sort	factors affecting nodal status in breast cancer
publisher	Al-Azhar University, Faculty of Medicine (Damietta)
publishDate	2020
url	https://doaj.org/article/8bbeaacc605342e2bcacdf45b42c27d4
work_keys_str_mv	AT diaaaboelata factorsaffectingnodalstatusinbreastcancer AT amrsarhan factorsaffectingnodalstatusinbreastcancer AT mohammedabomira factorsaffectingnodalstatusinbreastcancer AT samimohammed factorsaffectingnodalstatusinbreastcancer
_version_	1718392392414920704

Factors Affecting Nodal Status in Breast Cancer

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