Hepatic metastasis from perianal Paget’s disease without identified underlying carcinoma: a case report

Abstract Background Perianal Paget’s disease (PPD) is a rare malignancy, often associated with an underlying adenocarcinoma and a poor prognosis. Case presentation A 69-year-old female was presented with a history of perianal pruritus for 6 months and enlarged inguinal lymph nodes in the left side....

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yi-Sheng Cao, Shu-Yan Wang
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Perianal Paget’s disease Hepatic metastasis Underlying carcinoma Case report Surgery RD1-811 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/8bbf08ce48df4caaa297905deaebea41
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8bbf08ce48df4caaa297905deaebea41
record_format	dspace
spelling	oai:doaj.org-article:8bbf08ce48df4caaa297905deaebea412021-12-05T12:21:29ZHepatic metastasis from perianal Paget’s disease without identified underlying carcinoma: a case report10.1186/s12957-021-02439-41477-7819https://doaj.org/article/8bbf08ce48df4caaa297905deaebea412021-12-01T00:00:00Zhttps://doi.org/10.1186/s12957-021-02439-4https://doaj.org/toc/1477-7819Abstract Background Perianal Paget’s disease (PPD) is a rare malignancy, often associated with an underlying adenocarcinoma and a poor prognosis. Case presentation A 69-year-old female was presented with a history of perianal pruritus for 6 months and enlarged inguinal lymph nodes in the left side. Paget cells were confirmed by pathology after a wide excision of perianal skin. Radiotherapy was performed covering the bilateral inguinal lymphatic drainage area. Hepatic metastasis was found 8 months after surgery. Hepatic artery embolization (HAE) and high-intensity focused ultrasound therapy (HIFU) were performed successively. However, hepatic metastasis happened again 3 months later. Ultrasound-guided percutaneous radiofrequency ablation (PRFA) was carried out and various means of inspection could not identify the primary tumor. In the case of rapid progression of the tumor, we gave the patient chemotherapy regimens of XELOX. After 4 cycles of chemotherapy, the tumor marker went down continuously and the hepatic metastasis stayed stable. Conclusions Hepatic metastasis from perianal Paget’s disease without identified underlying carcinoma may benefit from XELOX on the basis of adenocarcinoma.Yi-Sheng CaoShu-Yan WangBMCarticlePerianal Paget’s diseaseHepatic metastasisUnderlying carcinomaCase reportSurgeryRD1-811Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENWorld Journal of Surgical Oncology, Vol 19, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Perianal Paget’s disease Hepatic metastasis Underlying carcinoma Case report Surgery RD1-811 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Perianal Paget’s disease Hepatic metastasis Underlying carcinoma Case report Surgery RD1-811 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Yi-Sheng Cao Shu-Yan Wang Hepatic metastasis from perianal Paget’s disease without identified underlying carcinoma: a case report
description	Abstract Background Perianal Paget’s disease (PPD) is a rare malignancy, often associated with an underlying adenocarcinoma and a poor prognosis. Case presentation A 69-year-old female was presented with a history of perianal pruritus for 6 months and enlarged inguinal lymph nodes in the left side. Paget cells were confirmed by pathology after a wide excision of perianal skin. Radiotherapy was performed covering the bilateral inguinal lymphatic drainage area. Hepatic metastasis was found 8 months after surgery. Hepatic artery embolization (HAE) and high-intensity focused ultrasound therapy (HIFU) were performed successively. However, hepatic metastasis happened again 3 months later. Ultrasound-guided percutaneous radiofrequency ablation (PRFA) was carried out and various means of inspection could not identify the primary tumor. In the case of rapid progression of the tumor, we gave the patient chemotherapy regimens of XELOX. After 4 cycles of chemotherapy, the tumor marker went down continuously and the hepatic metastasis stayed stable. Conclusions Hepatic metastasis from perianal Paget’s disease without identified underlying carcinoma may benefit from XELOX on the basis of adenocarcinoma.
format	article
author	Yi-Sheng Cao Shu-Yan Wang
author_facet	Yi-Sheng Cao Shu-Yan Wang
author_sort	Yi-Sheng Cao
title	Hepatic metastasis from perianal Paget’s disease without identified underlying carcinoma: a case report
title_short	Hepatic metastasis from perianal Paget’s disease without identified underlying carcinoma: a case report
title_full	Hepatic metastasis from perianal Paget’s disease without identified underlying carcinoma: a case report
title_fullStr	Hepatic metastasis from perianal Paget’s disease without identified underlying carcinoma: a case report
title_full_unstemmed	Hepatic metastasis from perianal Paget’s disease without identified underlying carcinoma: a case report
title_sort	hepatic metastasis from perianal paget’s disease without identified underlying carcinoma: a case report
publisher	BMC
publishDate	2021
url	https://doaj.org/article/8bbf08ce48df4caaa297905deaebea41
work_keys_str_mv	AT yishengcao hepaticmetastasisfromperianalpagetsdiseasewithoutidentifiedunderlyingcarcinomaacasereport AT shuyanwang hepaticmetastasisfromperianalpagetsdiseasewithoutidentifiedunderlyingcarcinomaacasereport
_version_	1718372028366454784

Hepatic metastasis from perianal Paget’s disease without identified underlying carcinoma: a case report

Ejemplares similares