Assessment of Vascular Changes in Patients after Pars Plana Vitrectomy Surgery Due to Macula-Off Rhegmatogenous Retinal Detachment

The aim of this study was to investigate the changes in the retinal capillary plexuses in patients after pars plana vitrectomy (PPV), which is used for the treatment of rhegmatogenous retinal detachment (RRD). In this study, we included the results of 114 patients who underwent PPV after total retin...

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Autores principales:	Anita Lyssek-Boroń, Adam Wylęgała, Katarzyna Krysik, Dominika Janiszewska-Bil, Edward Wylęgała, Beniamin Oskar Grabarek, Dariusz Dobrowolski
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	macula-off rhegmatogenous detachment optical coherence tomography angiography superficial perifoveal capillary plexus retinal deep perifoveal capillary plexus Medicine R
Acceso en línea:	https://doaj.org/article/8bbf2b7c97934d0dbabb3d3b6320c921
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spelling	oai:doaj.org-article:8bbf2b7c97934d0dbabb3d3b6320c9212021-11-11T17:40:38ZAssessment of Vascular Changes in Patients after Pars Plana Vitrectomy Surgery Due to Macula-Off Rhegmatogenous Retinal Detachment10.3390/jcm102150542077-0383https://doaj.org/article/8bbf2b7c97934d0dbabb3d3b6320c9212021-10-01T00:00:00Zhttps://www.mdpi.com/2077-0383/10/21/5054https://doaj.org/toc/2077-0383The aim of this study was to investigate the changes in the retinal capillary plexuses in patients after pars plana vitrectomy (PPV), which is used for the treatment of rhegmatogenous retinal detachment (RRD). In this study, we included the results of 114 patients who underwent PPV after total retinal detachment (RRD; retinal detachment group). It should be kept in mind that to qualify for the study group, there was a condition that retinal detachment be only present in one eye, allowing the fellow healthy eye to be used for the control group, and the study, therefore, did not include cases where retinal detachment occurred binocularly. Optical coherence tomography (OCT) and OCT-A images were taken at 9 ± 2 months (median 10 months) after the surgery, with the study conducted in the years 2017–2019. OCT was used to examine the external limiting membrane (ELM), central macular thickness (CMT) and retinal nerve fiber layer (RNFL), while OCT-angiography (OCT-A) was used to examine the extent of the foveal avascular zone (FAZ) in the deep and superficial capillary plexuses. Changes in the FAZ area of the superficial plexus (SCP) between the study and control groups were analyzed over 346 ± 50 days. In our study, we observed changes in the FAZ area between the RRD and control groups in the SCP (203.65 ± 31.69 μm<sup>2</sup> vs. 215.30 ± 35.82 μm<sup>2</sup>; <i>p</i> = 0.28733) and DCP (284.79 ± 35.82 µm<sup>2</sup> vs. 336.84 ± 32.23 µm<sup>2</sup>; <i>p</i> = 0.00924). Changes in the RNFL thickness between the study and control groups over 346 ± 50 days were as follows: 90.15 μm vs. 82.44 μm; <i>p</i> = 0.19773. Disruption of the external limiting membrane was observed in 78.95% (90 eyes) of the study group. In the control group, it was undamaged, and no integrity disorder was observed. In the RRD, changes occurred in the FAZ of both the SCP and the DCP, which reduced the extent of this zone, an effect that was more pronounced in DCPs. A better understanding of the anatomical and hemodynamic changes taking place in the retina after macula-off RRD might be helpful in answering the question as to why BCVA in these cases is “only” or “as much as” from 0.4 to 0.1, namely, that it might be related to changes in the neurosensory retina after macular peeling.Anita Lyssek-BorońAdam WylęgałaKatarzyna KrysikDominika Janiszewska-BilEdward WylęgałaBeniamin Oskar GrabarekDariusz DobrowolskiMDPI AGarticlemacula-off rhegmatogenous detachmentoptical coherence tomography angiographysuperficial perifoveal capillary plexusretinal deep perifoveal capillary plexusMedicineRENJournal of Clinical Medicine, Vol 10, Iss 5054, p 5054 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	macula-off rhegmatogenous detachment optical coherence tomography angiography superficial perifoveal capillary plexus retinal deep perifoveal capillary plexus Medicine R
spellingShingle	macula-off rhegmatogenous detachment optical coherence tomography angiography superficial perifoveal capillary plexus retinal deep perifoveal capillary plexus Medicine R Anita Lyssek-Boroń Adam Wylęgała Katarzyna Krysik Dominika Janiszewska-Bil Edward Wylęgała Beniamin Oskar Grabarek Dariusz Dobrowolski Assessment of Vascular Changes in Patients after Pars Plana Vitrectomy Surgery Due to Macula-Off Rhegmatogenous Retinal Detachment
description	The aim of this study was to investigate the changes in the retinal capillary plexuses in patients after pars plana vitrectomy (PPV), which is used for the treatment of rhegmatogenous retinal detachment (RRD). In this study, we included the results of 114 patients who underwent PPV after total retinal detachment (RRD; retinal detachment group). It should be kept in mind that to qualify for the study group, there was a condition that retinal detachment be only present in one eye, allowing the fellow healthy eye to be used for the control group, and the study, therefore, did not include cases where retinal detachment occurred binocularly. Optical coherence tomography (OCT) and OCT-A images were taken at 9 ± 2 months (median 10 months) after the surgery, with the study conducted in the years 2017–2019. OCT was used to examine the external limiting membrane (ELM), central macular thickness (CMT) and retinal nerve fiber layer (RNFL), while OCT-angiography (OCT-A) was used to examine the extent of the foveal avascular zone (FAZ) in the deep and superficial capillary plexuses. Changes in the FAZ area of the superficial plexus (SCP) between the study and control groups were analyzed over 346 ± 50 days. In our study, we observed changes in the FAZ area between the RRD and control groups in the SCP (203.65 ± 31.69 μm<sup>2</sup> vs. 215.30 ± 35.82 μm<sup>2</sup>; <i>p</i> = 0.28733) and DCP (284.79 ± 35.82 µm<sup>2</sup> vs. 336.84 ± 32.23 µm<sup>2</sup>; <i>p</i> = 0.00924). Changes in the RNFL thickness between the study and control groups over 346 ± 50 days were as follows: 90.15 μm vs. 82.44 μm; <i>p</i> = 0.19773. Disruption of the external limiting membrane was observed in 78.95% (90 eyes) of the study group. In the control group, it was undamaged, and no integrity disorder was observed. In the RRD, changes occurred in the FAZ of both the SCP and the DCP, which reduced the extent of this zone, an effect that was more pronounced in DCPs. A better understanding of the anatomical and hemodynamic changes taking place in the retina after macula-off RRD might be helpful in answering the question as to why BCVA in these cases is “only” or “as much as” from 0.4 to 0.1, namely, that it might be related to changes in the neurosensory retina after macular peeling.
format	article
author	Anita Lyssek-Boroń Adam Wylęgała Katarzyna Krysik Dominika Janiszewska-Bil Edward Wylęgała Beniamin Oskar Grabarek Dariusz Dobrowolski
author_facet	Anita Lyssek-Boroń Adam Wylęgała Katarzyna Krysik Dominika Janiszewska-Bil Edward Wylęgała Beniamin Oskar Grabarek Dariusz Dobrowolski
author_sort	Anita Lyssek-Boroń
title	Assessment of Vascular Changes in Patients after Pars Plana Vitrectomy Surgery Due to Macula-Off Rhegmatogenous Retinal Detachment
title_short	Assessment of Vascular Changes in Patients after Pars Plana Vitrectomy Surgery Due to Macula-Off Rhegmatogenous Retinal Detachment
title_full	Assessment of Vascular Changes in Patients after Pars Plana Vitrectomy Surgery Due to Macula-Off Rhegmatogenous Retinal Detachment
title_fullStr	Assessment of Vascular Changes in Patients after Pars Plana Vitrectomy Surgery Due to Macula-Off Rhegmatogenous Retinal Detachment
title_full_unstemmed	Assessment of Vascular Changes in Patients after Pars Plana Vitrectomy Surgery Due to Macula-Off Rhegmatogenous Retinal Detachment
title_sort	assessment of vascular changes in patients after pars plana vitrectomy surgery due to macula-off rhegmatogenous retinal detachment
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/8bbf2b7c97934d0dbabb3d3b6320c921
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Assessment of Vascular Changes in Patients after Pars Plana Vitrectomy Surgery Due to Macula-Off Rhegmatogenous Retinal Detachment

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