ACTIVITY OF HOST DEFENSE FUNCTIONS IN STRESS CONDITIONS AND THEIR CORRECTION BY THE DERINAT DRUG

Abstract. Studies in altered functional activity of immunocompetent cells (peritoneal macrophages, lymphocytes and natural killer cells of the spleen), as well as concentrations of glucocorticoid hormones and testosterone were performed in peripheral blood of rats, subjected to cold stress at differ...

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Autores principales:	E. G. Rybakina, S. N. Shanin, E. E. Fomicheva, I. A. Kozinec, E. A. Korneva
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	derinat immunocompetent cells hormones stress Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/8bc018687dad4e0098c5b6530f613676
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spelling	oai:doaj.org-article:8bc018687dad4e0098c5b6530f6136762021-11-18T08:03:39ZACTIVITY OF HOST DEFENSE FUNCTIONS IN STRESS CONDITIONS AND THEIR CORRECTION BY THE DERINAT DRUG1563-06252313-741X10.15789/1563-0625-2008-4-5-431-438https://doaj.org/article/8bc018687dad4e0098c5b6530f6136762014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/208https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Studies in altered functional activity of immunocompetent cells (peritoneal macrophages, lymphocytes and natural killer cells of the spleen), as well as concentrations of glucocorticoid hormones and testosterone were performed in peripheral blood of rats, subjected to cold stress at different regimens. Moreover, a corrective effect of Derinat drug upon the mentioned indices of host defense functions was evaluated. The changes in functional activity of immunocompetent cells were found to be dependent on intensity of stress application, whereas alterations in blood hormone level did not depend on these conditions, i.e., application of both stress models revealed increased corticosterone concentrations and reduced testosterone levels in rat blood. A novel protective effect of Derinat under stress conditions was shown which manifested as a prevention of stress-induced testosterone decrease in blood. In present study, we have demonstrated both immunomodulatory effects and normalizing action of Derinat upon changed activities of immunocompetent cells induced by stress factors. The results obtained allow us to conclude that the strategy of correcting altered functional activity of immune system cells may include, e.g., application of native DNA preparations. (Med. Immunol., vol. 10, N 4-5, pp 431-438).E. G. RybakinaS. N. ShaninE. E. FomichevaI. A. KozinecE. A. KornevaSPb RAACIarticlederinatimmunocompetent cellshormonesstressImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 10, Iss 4-5, Pp 431-438 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	derinat immunocompetent cells hormones stress Immunologic diseases. Allergy RC581-607
spellingShingle	derinat immunocompetent cells hormones stress Immunologic diseases. Allergy RC581-607 E. G. Rybakina S. N. Shanin E. E. Fomicheva I. A. Kozinec E. A. Korneva ACTIVITY OF HOST DEFENSE FUNCTIONS IN STRESS CONDITIONS AND THEIR CORRECTION BY THE DERINAT DRUG
description	Abstract. Studies in altered functional activity of immunocompetent cells (peritoneal macrophages, lymphocytes and natural killer cells of the spleen), as well as concentrations of glucocorticoid hormones and testosterone were performed in peripheral blood of rats, subjected to cold stress at different regimens. Moreover, a corrective effect of Derinat drug upon the mentioned indices of host defense functions was evaluated. The changes in functional activity of immunocompetent cells were found to be dependent on intensity of stress application, whereas alterations in blood hormone level did not depend on these conditions, i.e., application of both stress models revealed increased corticosterone concentrations and reduced testosterone levels in rat blood. A novel protective effect of Derinat under stress conditions was shown which manifested as a prevention of stress-induced testosterone decrease in blood. In present study, we have demonstrated both immunomodulatory effects and normalizing action of Derinat upon changed activities of immunocompetent cells induced by stress factors. The results obtained allow us to conclude that the strategy of correcting altered functional activity of immune system cells may include, e.g., application of native DNA preparations. (Med. Immunol., vol. 10, N 4-5, pp 431-438).
format	article
author	E. G. Rybakina S. N. Shanin E. E. Fomicheva I. A. Kozinec E. A. Korneva
author_facet	E. G. Rybakina S. N. Shanin E. E. Fomicheva I. A. Kozinec E. A. Korneva
author_sort	E. G. Rybakina
title	ACTIVITY OF HOST DEFENSE FUNCTIONS IN STRESS CONDITIONS AND THEIR CORRECTION BY THE DERINAT DRUG
title_short	ACTIVITY OF HOST DEFENSE FUNCTIONS IN STRESS CONDITIONS AND THEIR CORRECTION BY THE DERINAT DRUG
title_full	ACTIVITY OF HOST DEFENSE FUNCTIONS IN STRESS CONDITIONS AND THEIR CORRECTION BY THE DERINAT DRUG
title_fullStr	ACTIVITY OF HOST DEFENSE FUNCTIONS IN STRESS CONDITIONS AND THEIR CORRECTION BY THE DERINAT DRUG
title_full_unstemmed	ACTIVITY OF HOST DEFENSE FUNCTIONS IN STRESS CONDITIONS AND THEIR CORRECTION BY THE DERINAT DRUG
title_sort	activity of host defense functions in stress conditions and their correction by the derinat drug
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/8bc018687dad4e0098c5b6530f613676
work_keys_str_mv	AT egrybakina activityofhostdefensefunctionsinstressconditionsandtheircorrectionbythederinatdrug AT snshanin activityofhostdefensefunctionsinstressconditionsandtheircorrectionbythederinatdrug AT eefomicheva activityofhostdefensefunctionsinstressconditionsandtheircorrectionbythederinatdrug AT iakozinec activityofhostdefensefunctionsinstressconditionsandtheircorrectionbythederinatdrug AT eakorneva activityofhostdefensefunctionsinstressconditionsandtheircorrectionbythederinatdrug
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ACTIVITY OF HOST DEFENSE FUNCTIONS IN STRESS CONDITIONS AND THEIR CORRECTION BY THE DERINAT DRUG

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