Long-term icariin treatment ameliorates cognitive deficits via CD4+ T cell-mediated immuno-inflammatory responses in APP/PS1 mice

Long-term icariin treatment ameliorates cognitive deficits via CD4+ T cell-mediated immuno-inflammatory responses in APP/PS1 mice

Tianrui Zhu,1 Feng Zhang,1 Heng Li,1 Yi He,2 Guitao Zhang,1 Nana Huang,1 Mingming Guo,3 Xiaohong Li11Department of Neurology, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong 250013, People’s Republic of China; 2Department of Neurology, The Second Affiliated Hospit...

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Autores principales: Zhu T, Zhang F, Li H, He Y, Zhang G, Huang N, Guo M, Li X
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2019
Materias:
Alzheimer’s disease
icariin
T lymphocyte
neuroinflammation
cytokines
Geriatrics
RC952-954.6
Acceso en línea:https://doaj.org/article/8bc3384e54744385bb346bd0dd6733e1
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spelling oai:doaj.org-article:8bc3384e54744385bb346bd0dd6733e12021-12-02T11:41:43ZLong-term icariin treatment ameliorates cognitive deficits via CD4+ T cell-mediated immuno-inflammatory responses in APP/PS1 mice1178-1998https://doaj.org/article/8bc3384e54744385bb346bd0dd6733e12019-05-01T00:00:00Zhttps://www.dovepress.com/long-term-icariin-treatment-ameliorates-cognitive-deficits-via-cd4-t-c-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Tianrui Zhu,1 Feng Zhang,1 Heng Li,1 Yi He,2 Guitao Zhang,1 Nana Huang,1 Mingming Guo,3 Xiaohong Li11Department of Neurology, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong 250013, People’s Republic of China; 2Department of Neurology, The Second Affiliated Hospital of Xi’an Medical University, Xi’an, Shaanxi 710021, People’s Republic of China; 3Department of Breast Surgery, The Second Hospital of Shandong University, Jinan, Shandong 250033, People’s Republic of ChinaBackground: Alzheimer’s disease (AD) is the most common neurodegenerative disorder that also involves neuroinflammation in addition to many other features. Icariin (ICA) as one of the active ingredients of Chinese herbal medicine has the immunomodulating function. This study aimed to investigate the immunotherapeutic potential of ICA on AD.Methods: APP/PS1 mice and wild type C57BL/6 mice were subjected to orally ICA administration (60 mg/kg/d) for 8 months. Then, the ethological and biochemical experiments, such as Morris water maze assay, Aβ ELISA, blood T cell flow cytometry, and plasma and brain cytokines array, were conducted to evaluate the effects of ICA administration.Results: ICA significantly improved spatial learning and memory retention in APP/PS1 mice. Long-term application of ICA could also reduce hippocampus Aβ deposition, modulate the differentiation of CD4+ T cells, and modulate the release of inflammatory cytokines in plasma and brain tissue.Conclusion: ICA shows the neuroprotective effects via modulating the CD4+ T lymphocyte-related immuno-inflammatory responses in APP/PS1 mice and may be a promising drug against AD progression.Keywords: Alzheimer’s disease, icariin, T lymphocyte, neuroinflammation, cytokinesZhu TZhang FLi HHe YZhang GHuang NGuo MLi XDove Medical PressarticleAlzheimer’s diseaseicariinT lymphocyteneuroinflammationcytokinesGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 14, Pp 817-826 (2019)
institution DOAJ
collection DOAJ
language EN
topic Alzheimer’s disease
icariin
T lymphocyte
neuroinflammation
cytokines
Geriatrics
RC952-954.6
spellingShingle Alzheimer’s disease
icariin
T lymphocyte
neuroinflammation
cytokines
Geriatrics
RC952-954.6
Zhu T
Zhang F
Li H
He Y
Zhang G
Huang N
Guo M
Li X
Long-term icariin treatment ameliorates cognitive deficits via CD4+ T cell-mediated immuno-inflammatory responses in APP/PS1 mice
description Tianrui Zhu,1 Feng Zhang,1 Heng Li,1 Yi He,2 Guitao Zhang,1 Nana Huang,1 Mingming Guo,3 Xiaohong Li11Department of Neurology, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong 250013, People’s Republic of China; 2Department of Neurology, The Second Affiliated Hospital of Xi’an Medical University, Xi’an, Shaanxi 710021, People’s Republic of China; 3Department of Breast Surgery, The Second Hospital of Shandong University, Jinan, Shandong 250033, People’s Republic of ChinaBackground: Alzheimer’s disease (AD) is the most common neurodegenerative disorder that also involves neuroinflammation in addition to many other features. Icariin (ICA) as one of the active ingredients of Chinese herbal medicine has the immunomodulating function. This study aimed to investigate the immunotherapeutic potential of ICA on AD.Methods: APP/PS1 mice and wild type C57BL/6 mice were subjected to orally ICA administration (60 mg/kg/d) for 8 months. Then, the ethological and biochemical experiments, such as Morris water maze assay, Aβ ELISA, blood T cell flow cytometry, and plasma and brain cytokines array, were conducted to evaluate the effects of ICA administration.Results: ICA significantly improved spatial learning and memory retention in APP/PS1 mice. Long-term application of ICA could also reduce hippocampus Aβ deposition, modulate the differentiation of CD4+ T cells, and modulate the release of inflammatory cytokines in plasma and brain tissue.Conclusion: ICA shows the neuroprotective effects via modulating the CD4+ T lymphocyte-related immuno-inflammatory responses in APP/PS1 mice and may be a promising drug against AD progression.Keywords: Alzheimer’s disease, icariin, T lymphocyte, neuroinflammation, cytokines
format article
author Zhu T
Zhang F
Li H
He Y
Zhang G
Huang N
Guo M
Li X
author_facet Zhu T
Zhang F
Li H
He Y
Zhang G
Huang N
Guo M
Li X
author_sort Zhu T
title Long-term icariin treatment ameliorates cognitive deficits via CD4+ T cell-mediated immuno-inflammatory responses in APP/PS1 mice
title_short Long-term icariin treatment ameliorates cognitive deficits via CD4+ T cell-mediated immuno-inflammatory responses in APP/PS1 mice
title_full Long-term icariin treatment ameliorates cognitive deficits via CD4+ T cell-mediated immuno-inflammatory responses in APP/PS1 mice
title_fullStr Long-term icariin treatment ameliorates cognitive deficits via CD4+ T cell-mediated immuno-inflammatory responses in APP/PS1 mice
title_full_unstemmed Long-term icariin treatment ameliorates cognitive deficits via CD4+ T cell-mediated immuno-inflammatory responses in APP/PS1 mice
title_sort long-term icariin treatment ameliorates cognitive deficits via cd4+ t cell-mediated immuno-inflammatory responses in app/ps1 mice
publisher Dove Medical Press
publishDate 2019
url https://doaj.org/article/8bc3384e54744385bb346bd0dd6733e1
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