Ultra-long-acting tunable biodegradable and removable controlled release implants for drug delivery

Patient drug regime compliance is a major issue; sustained release implants could address this. Here, the authors report on a phase inverted in situ forming implant of PLGA for the sustained release of antiretroviral drugs and optimize and demonstrate the release of 6 different drugs over a period o...

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Autores principales:	S. Rahima Benhabbour, Martina Kovarova, Clinton Jones, Daijha J. Copeland, Roopali Shrivastava, Michael D. Swanson, Craig Sykes, Phong T. Ho, Mackenzie L. Cottrell, Anush Sridharan, Samantha M. Fix, Orrin Thayer, Julie M. Long, Daria J. Hazuda, Paul A. Dayton, Russell J. Mumper, Angela D. M. Kashuba, J. Victor Garcia
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8bc4a989ec17413397ece8fc45f93686
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spelling	oai:doaj.org-article:8bc4a989ec17413397ece8fc45f936862021-12-02T15:36:21ZUltra-long-acting tunable biodegradable and removable controlled release implants for drug delivery10.1038/s41467-019-12141-52041-1723https://doaj.org/article/8bc4a989ec17413397ece8fc45f936862019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12141-5https://doaj.org/toc/2041-1723Patient drug regime compliance is a major issue; sustained release implants could address this. Here, the authors report on a phase inverted in situ forming implant of PLGA for the sustained release of antiretroviral drugs and optimize and demonstrate the release of 6 different drugs over a period of up to a year.S. Rahima BenhabbourMartina KovarovaClinton JonesDaijha J. CopelandRoopali ShrivastavaMichael D. SwansonCraig SykesPhong T. HoMackenzie L. CottrellAnush SridharanSamantha M. FixOrrin ThayerJulie M. LongDaria J. HazudaPaul A. DaytonRussell J. MumperAngela D. M. KashubaJ. Victor GarciaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q S. Rahima Benhabbour Martina Kovarova Clinton Jones Daijha J. Copeland Roopali Shrivastava Michael D. Swanson Craig Sykes Phong T. Ho Mackenzie L. Cottrell Anush Sridharan Samantha M. Fix Orrin Thayer Julie M. Long Daria J. Hazuda Paul A. Dayton Russell J. Mumper Angela D. M. Kashuba J. Victor Garcia Ultra-long-acting tunable biodegradable and removable controlled release implants for drug delivery
description	Patient drug regime compliance is a major issue; sustained release implants could address this. Here, the authors report on a phase inverted in situ forming implant of PLGA for the sustained release of antiretroviral drugs and optimize and demonstrate the release of 6 different drugs over a period of up to a year.
format	article
author	S. Rahima Benhabbour Martina Kovarova Clinton Jones Daijha J. Copeland Roopali Shrivastava Michael D. Swanson Craig Sykes Phong T. Ho Mackenzie L. Cottrell Anush Sridharan Samantha M. Fix Orrin Thayer Julie M. Long Daria J. Hazuda Paul A. Dayton Russell J. Mumper Angela D. M. Kashuba J. Victor Garcia
author_facet	S. Rahima Benhabbour Martina Kovarova Clinton Jones Daijha J. Copeland Roopali Shrivastava Michael D. Swanson Craig Sykes Phong T. Ho Mackenzie L. Cottrell Anush Sridharan Samantha M. Fix Orrin Thayer Julie M. Long Daria J. Hazuda Paul A. Dayton Russell J. Mumper Angela D. M. Kashuba J. Victor Garcia
author_sort	S. Rahima Benhabbour
title	Ultra-long-acting tunable biodegradable and removable controlled release implants for drug delivery
title_short	Ultra-long-acting tunable biodegradable and removable controlled release implants for drug delivery
title_full	Ultra-long-acting tunable biodegradable and removable controlled release implants for drug delivery
title_fullStr	Ultra-long-acting tunable biodegradable and removable controlled release implants for drug delivery
title_full_unstemmed	Ultra-long-acting tunable biodegradable and removable controlled release implants for drug delivery
title_sort	ultra-long-acting tunable biodegradable and removable controlled release implants for drug delivery
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/8bc4a989ec17413397ece8fc45f93686
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Ultra-long-acting tunable biodegradable and removable controlled release implants for drug delivery

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