Implication of problematic substance use in poststroke depression: an hospital-based study

Abstract The prevalence of clinically defined problematic substance use among stroke patients is overlooked and its association with post-stroke depression (PSD) is unknown. Our aims were to: (1) estimate the proportion of stroke patients with a problematic substance use as defined by clinical scree...

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Autores principales:	Yolaine Rabat, Igor Sibon, Sylvie Berthoz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8bcb0c739c0843b1a0e14a8862e5546f
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spelling	oai:doaj.org-article:8bcb0c739c0843b1a0e14a8862e5546f2021-12-02T18:02:54ZImplication of problematic substance use in poststroke depression: an hospital-based study10.1038/s41598-021-92639-52045-2322https://doaj.org/article/8bcb0c739c0843b1a0e14a8862e5546f2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92639-5https://doaj.org/toc/2045-2322Abstract The prevalence of clinically defined problematic substance use among stroke patients is overlooked and its association with post-stroke depression (PSD) is unknown. Our aims were to: (1) estimate the proportion of stroke patients with a problematic substance use as defined by clinical screening scales; (2) determine the proportion of PSD at three months of follow-up; (3) explore if the baseline severity in substance use and its evolution are independent predictors of PSD. A cohort of first-ever non-severe stroke adult patients was screened at baseline and three months post-stroke using recommended cut-off scores of standardized scales for tobacco, alcohol and cannabis abuse. PSD was defined using the Center of Epidemiological Studies Depression scale score. Out of the 244 eligible patients, 74 (30.3%) presented a problematic substance use, including 21 (8.6%) polydrug abusers. Among these patients, the prevalence of PSD was 50.8%, including 29.5% of severe depression. The severity of tobacco dependence at baseline was found to double the risk (OR 1.59, 95% CI 1.05–2.43) of presenting a PSD, independently of previously reported risk factors. We found no significant evidence for an effect of the evolution in substance use at follow-up. Addictive disorders are part of the critical unmet needs that should be addressed in the management of PSD.Yolaine RabatIgor SibonSylvie BerthozNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yolaine Rabat Igor Sibon Sylvie Berthoz Implication of problematic substance use in poststroke depression: an hospital-based study
description	Abstract The prevalence of clinically defined problematic substance use among stroke patients is overlooked and its association with post-stroke depression (PSD) is unknown. Our aims were to: (1) estimate the proportion of stroke patients with a problematic substance use as defined by clinical screening scales; (2) determine the proportion of PSD at three months of follow-up; (3) explore if the baseline severity in substance use and its evolution are independent predictors of PSD. A cohort of first-ever non-severe stroke adult patients was screened at baseline and three months post-stroke using recommended cut-off scores of standardized scales for tobacco, alcohol and cannabis abuse. PSD was defined using the Center of Epidemiological Studies Depression scale score. Out of the 244 eligible patients, 74 (30.3%) presented a problematic substance use, including 21 (8.6%) polydrug abusers. Among these patients, the prevalence of PSD was 50.8%, including 29.5% of severe depression. The severity of tobacco dependence at baseline was found to double the risk (OR 1.59, 95% CI 1.05–2.43) of presenting a PSD, independently of previously reported risk factors. We found no significant evidence for an effect of the evolution in substance use at follow-up. Addictive disorders are part of the critical unmet needs that should be addressed in the management of PSD.
format	article
author	Yolaine Rabat Igor Sibon Sylvie Berthoz
author_facet	Yolaine Rabat Igor Sibon Sylvie Berthoz
author_sort	Yolaine Rabat
title	Implication of problematic substance use in poststroke depression: an hospital-based study
title_short	Implication of problematic substance use in poststroke depression: an hospital-based study
title_full	Implication of problematic substance use in poststroke depression: an hospital-based study
title_fullStr	Implication of problematic substance use in poststroke depression: an hospital-based study
title_full_unstemmed	Implication of problematic substance use in poststroke depression: an hospital-based study
title_sort	implication of problematic substance use in poststroke depression: an hospital-based study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8bcb0c739c0843b1a0e14a8862e5546f
work_keys_str_mv	AT yolainerabat implicationofproblematicsubstanceuseinpoststrokedepressionanhospitalbasedstudy AT igorsibon implicationofproblematicsubstanceuseinpoststrokedepressionanhospitalbasedstudy AT sylvieberthoz implicationofproblematicsubstanceuseinpoststrokedepressionanhospitalbasedstudy
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Implication of problematic substance use in poststroke depression: an hospital-based study

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