Obsessive-compulsive disorder with bipolar diathesis following isotretinoin therapy remitting upon treatment with olanzapine and fluvoxamine

Michele FornaroDepartment of Neuroscience, Section of Psychiatry, University of Genoa, Genoa, ItalyAbstract: Isotretinoin, a drug used for moderate to severe acne, has been repeatedly associated with various psychiatric complications, although a definitive causal relationship has not been establishe...

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Autor principal:	Michele Fornaro
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/8bd20d0f69ae4036916b493c8c752bb5
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spelling	oai:doaj.org-article:8bd20d0f69ae4036916b493c8c752bb52021-12-02T00:22:38ZObsessive-compulsive disorder with bipolar diathesis following isotretinoin therapy remitting upon treatment with olanzapine and fluvoxamine1176-63281178-2021https://doaj.org/article/8bd20d0f69ae4036916b493c8c752bb52010-10-01T00:00:00Zhttp://www.dovepress.com/obsessive-compulsive-disorder-with-bipolar-diathesis-following-isotret-a5577https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Michele FornaroDepartment of Neuroscience, Section of Psychiatry, University of Genoa, Genoa, ItalyAbstract: Isotretinoin, a drug used for moderate to severe acne, has been repeatedly associated with various psychiatric complications, although a definitive causal relationship has not been established to date. This case report describes a 25-year-old male who developed obsessive-compulsive disorder at the age of 23 years following isotretinoin treatment for acne (10&ndash;20 mg/day) since the age of 16 years. Although standard treatment for obsessive-compulsive disorder caused mood swings, the combination of fluvoxamine 300 mg/day and olanzapine 15 mg/day significantly improves the clinical picture. Although rare, severe adulthood psychiatric complications may occur following isotretinoin treatment, requiring management which is individually tailored to the patient.Keywords: isotretinoin, obsessive-compulsive disorder, olanzapine, fluvoxamine, treatment Michele FornaroDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2010, Iss Issue 1, Pp 719-722 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Michele Fornaro Obsessive-compulsive disorder with bipolar diathesis following isotretinoin therapy remitting upon treatment with olanzapine and fluvoxamine
description	Michele FornaroDepartment of Neuroscience, Section of Psychiatry, University of Genoa, Genoa, ItalyAbstract: Isotretinoin, a drug used for moderate to severe acne, has been repeatedly associated with various psychiatric complications, although a definitive causal relationship has not been established to date. This case report describes a 25-year-old male who developed obsessive-compulsive disorder at the age of 23 years following isotretinoin treatment for acne (10&ndash;20 mg/day) since the age of 16 years. Although standard treatment for obsessive-compulsive disorder caused mood swings, the combination of fluvoxamine 300 mg/day and olanzapine 15 mg/day significantly improves the clinical picture. Although rare, severe adulthood psychiatric complications may occur following isotretinoin treatment, requiring management which is individually tailored to the patient.Keywords: isotretinoin, obsessive-compulsive disorder, olanzapine, fluvoxamine, treatment
format	article
author	Michele Fornaro
author_facet	Michele Fornaro
author_sort	Michele Fornaro
title	Obsessive-compulsive disorder with bipolar diathesis following isotretinoin therapy remitting upon treatment with olanzapine and fluvoxamine
title_short	Obsessive-compulsive disorder with bipolar diathesis following isotretinoin therapy remitting upon treatment with olanzapine and fluvoxamine
title_full	Obsessive-compulsive disorder with bipolar diathesis following isotretinoin therapy remitting upon treatment with olanzapine and fluvoxamine
title_fullStr	Obsessive-compulsive disorder with bipolar diathesis following isotretinoin therapy remitting upon treatment with olanzapine and fluvoxamine
title_full_unstemmed	Obsessive-compulsive disorder with bipolar diathesis following isotretinoin therapy remitting upon treatment with olanzapine and fluvoxamine
title_sort	obsessive-compulsive disorder with bipolar diathesis following isotretinoin therapy remitting upon treatment with olanzapine and fluvoxamine
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/8bd20d0f69ae4036916b493c8c752bb5
work_keys_str_mv	AT michelefornaro obsessivecompulsivedisorderwithbipolardiathesisfollowingisotretinointherapyremittingupontreatmentwitholanzapineandfluvoxamine
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Obsessive-compulsive disorder with bipolar diathesis following isotretinoin therapy remitting upon treatment with olanzapine and fluvoxamine

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