Exchange catalysis by tapasin exploits conserved and allele-specific features of MHC-I molecules

Tapasin is part of the peptide loading complex necessary for presenting antigenic peptides on MHC-I for the induction of adaptive immunity. Here the authors show that tapasin interacts with MHC-I in both conserved and allele-specific regions to promote antigen presentation, with tapasin L18 and K16...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Huan Lan, Esam T. Abualrous, Jana Sticht, Laura Maria Arroyo Fernandez, Tamina Werk, Christoph Weise, Martin Ballaschk, Peter Schmieder, Bernhard Loll, Christian Freund
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8bd32bbbde944e95a968d72ae29445ed
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8bd32bbbde944e95a968d72ae29445ed
record_format	dspace
spelling	oai:doaj.org-article:8bd32bbbde944e95a968d72ae29445ed2021-12-02T16:14:57ZExchange catalysis by tapasin exploits conserved and allele-specific features of MHC-I molecules10.1038/s41467-021-24401-42041-1723https://doaj.org/article/8bd32bbbde944e95a968d72ae29445ed2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24401-4https://doaj.org/toc/2041-1723Tapasin is part of the peptide loading complex necessary for presenting antigenic peptides on MHC-I for the induction of adaptive immunity. Here the authors show that tapasin interacts with MHC-I in both conserved and allele-specific regions to promote antigen presentation, with tapasin L18 and K16 residues both implicated in this molecular interaction.Huan LanEsam T. AbualrousJana StichtLaura Maria Arroyo FernandezTamina WerkChristoph WeiseMartin BallaschkPeter SchmiederBernhard LollChristian FreundNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Huan Lan Esam T. Abualrous Jana Sticht Laura Maria Arroyo Fernandez Tamina Werk Christoph Weise Martin Ballaschk Peter Schmieder Bernhard Loll Christian Freund Exchange catalysis by tapasin exploits conserved and allele-specific features of MHC-I molecules
description	Tapasin is part of the peptide loading complex necessary for presenting antigenic peptides on MHC-I for the induction of adaptive immunity. Here the authors show that tapasin interacts with MHC-I in both conserved and allele-specific regions to promote antigen presentation, with tapasin L18 and K16 residues both implicated in this molecular interaction.
format	article
author	Huan Lan Esam T. Abualrous Jana Sticht Laura Maria Arroyo Fernandez Tamina Werk Christoph Weise Martin Ballaschk Peter Schmieder Bernhard Loll Christian Freund
author_facet	Huan Lan Esam T. Abualrous Jana Sticht Laura Maria Arroyo Fernandez Tamina Werk Christoph Weise Martin Ballaschk Peter Schmieder Bernhard Loll Christian Freund
author_sort	Huan Lan
title	Exchange catalysis by tapasin exploits conserved and allele-specific features of MHC-I molecules
title_short	Exchange catalysis by tapasin exploits conserved and allele-specific features of MHC-I molecules
title_full	Exchange catalysis by tapasin exploits conserved and allele-specific features of MHC-I molecules
title_fullStr	Exchange catalysis by tapasin exploits conserved and allele-specific features of MHC-I molecules
title_full_unstemmed	Exchange catalysis by tapasin exploits conserved and allele-specific features of MHC-I molecules
title_sort	exchange catalysis by tapasin exploits conserved and allele-specific features of mhc-i molecules
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8bd32bbbde944e95a968d72ae29445ed
work_keys_str_mv	AT huanlan exchangecatalysisbytapasinexploitsconservedandallelespecificfeaturesofmhcimolecules AT esamtabualrous exchangecatalysisbytapasinexploitsconservedandallelespecificfeaturesofmhcimolecules AT janasticht exchangecatalysisbytapasinexploitsconservedandallelespecificfeaturesofmhcimolecules AT lauramariaarroyofernandez exchangecatalysisbytapasinexploitsconservedandallelespecificfeaturesofmhcimolecules AT taminawerk exchangecatalysisbytapasinexploitsconservedandallelespecificfeaturesofmhcimolecules AT christophweise exchangecatalysisbytapasinexploitsconservedandallelespecificfeaturesofmhcimolecules AT martinballaschk exchangecatalysisbytapasinexploitsconservedandallelespecificfeaturesofmhcimolecules AT peterschmieder exchangecatalysisbytapasinexploitsconservedandallelespecificfeaturesofmhcimolecules AT bernhardloll exchangecatalysisbytapasinexploitsconservedandallelespecificfeaturesofmhcimolecules AT christianfreund exchangecatalysisbytapasinexploitsconservedandallelespecificfeaturesofmhcimolecules
_version_	1718384303539224576

Exchange catalysis by tapasin exploits conserved and allele-specific features of MHC-I molecules

Ejemplares similares