Changing Mad2 levels affects chromosome segregation and spindle assembly checkpoint control in female mouse meiosis I.

Changing Mad2 levels affects chromosome segregation and spindle assembly checkpoint control in female mouse meiosis I.

The spindle assembly checkpoint (SAC) ensures correct separation of sister chromatids in somatic cells and provokes a cell cycle arrest in metaphase if one chromatid is not correctly attached to the bipolar spindle. Prolonged metaphase arrest due to overexpression of Mad2 has been shown to be delete...

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Autores principales: Théodora Niault, Khaled Hached, Rocío Sotillo, Peter K Sorger, Bernard Maro, Robert Benezra, Katja Wassmann
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2007
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/8bd4d848e5924c1cad0b23413be343a5
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