Insight into the morphology, pore structure and sorption properties of 4-hydroxy-3-nitrophenylacetic acid imprinted poly(acrylic acid-co-ethylene glycol dimethacrylate) sorbent
In this paper the exploration of specific imprinted sorbent for 4-hydroxy-3-nitrophenylacetic acid (NHPA), an indicator of 3-nitrotyrosine, a biomarker of pathophysiological states, was described. The optimization of synthetic protocol, supported by theoretical studies, allowed to select NHPA imprin...
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| Autores principales: | , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Elsevier
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/8bd9edf8bff04b668fe660fa4234c433 |
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| Sumario: | In this paper the exploration of specific imprinted sorbent for 4-hydroxy-3-nitrophenylacetic acid (NHPA), an indicator of 3-nitrotyrosine, a biomarker of pathophysiological states, was described. The optimization of synthetic protocol, supported by theoretical studies, allowed to select NHPA imprinted poly(acrylic acid-co-ethylene glycol dimethacrylate) as the most specific polymer with imprinting factor equal to 2.27. The acrylic copolymers were characterized, revealing differences between the imprinted and non-imprinted material in the adsorption binding capacities (0.54 ± 0.12 and 0.335 ± 0.073 μmol g−1, respectively), heterogeneity indices (0.47 and 0.72), pseudo-second order kinetics constants (0.251 and 0.077 g μmol −1 min−1, respectively), and total specific surface areas (51.8 and 292.3 m2 g−1, respectively). The significant difference in the microstructure of pores was considered as the crucial factor responsible for sorption properties of analyzed materials. |
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