Impaired calcium signaling in astrocytes modulates autism spectrum disorder-like behaviors in mice

Astrocytes contribute to autism spectrum disorder (ASD) pathophysiology. Here, the authors show that IP3R2 conditional KO mice show ASD-like behaviours and identify astrocyte-derived ATP as a modulator of these behaviours in mice.

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Autores principales:	Qian Wang, Ying Kong, Ding-Yu Wu, Ji-Hong Liu, Wei Jie, Qiang-Long You, Lang Huang, Jian Hu, Huai-De Chu, Feng Gao, Neng-Yuan Hu, Zhou-Cai Luo, Xiao-Wen Li, Shu-Ji Li, Zhao-Fa Wu, Yu-Long Li, Jian-Ming Yang, Tian-Ming Gao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8bdbbf173fa34c22af105a449a7b98e1
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spelling	oai:doaj.org-article:8bdbbf173fa34c22af105a449a7b98e12021-12-02T15:56:54ZImpaired calcium signaling in astrocytes modulates autism spectrum disorder-like behaviors in mice10.1038/s41467-021-23843-02041-1723https://doaj.org/article/8bdbbf173fa34c22af105a449a7b98e12021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23843-0https://doaj.org/toc/2041-1723Astrocytes contribute to autism spectrum disorder (ASD) pathophysiology. Here, the authors show that IP3R2 conditional KO mice show ASD-like behaviours and identify astrocyte-derived ATP as a modulator of these behaviours in mice.Qian WangYing KongDing-Yu WuJi-Hong LiuWei JieQiang-Long YouLang HuangJian HuHuai-De ChuFeng GaoNeng-Yuan HuZhou-Cai LuoXiao-Wen LiShu-Ji LiZhao-Fa WuYu-Long LiJian-Ming YangTian-Ming GaoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Qian Wang Ying Kong Ding-Yu Wu Ji-Hong Liu Wei Jie Qiang-Long You Lang Huang Jian Hu Huai-De Chu Feng Gao Neng-Yuan Hu Zhou-Cai Luo Xiao-Wen Li Shu-Ji Li Zhao-Fa Wu Yu-Long Li Jian-Ming Yang Tian-Ming Gao Impaired calcium signaling in astrocytes modulates autism spectrum disorder-like behaviors in mice
description	Astrocytes contribute to autism spectrum disorder (ASD) pathophysiology. Here, the authors show that IP3R2 conditional KO mice show ASD-like behaviours and identify astrocyte-derived ATP as a modulator of these behaviours in mice.
format	article
author	Qian Wang Ying Kong Ding-Yu Wu Ji-Hong Liu Wei Jie Qiang-Long You Lang Huang Jian Hu Huai-De Chu Feng Gao Neng-Yuan Hu Zhou-Cai Luo Xiao-Wen Li Shu-Ji Li Zhao-Fa Wu Yu-Long Li Jian-Ming Yang Tian-Ming Gao
author_facet	Qian Wang Ying Kong Ding-Yu Wu Ji-Hong Liu Wei Jie Qiang-Long You Lang Huang Jian Hu Huai-De Chu Feng Gao Neng-Yuan Hu Zhou-Cai Luo Xiao-Wen Li Shu-Ji Li Zhao-Fa Wu Yu-Long Li Jian-Ming Yang Tian-Ming Gao
author_sort	Qian Wang
title	Impaired calcium signaling in astrocytes modulates autism spectrum disorder-like behaviors in mice
title_short	Impaired calcium signaling in astrocytes modulates autism spectrum disorder-like behaviors in mice
title_full	Impaired calcium signaling in astrocytes modulates autism spectrum disorder-like behaviors in mice
title_fullStr	Impaired calcium signaling in astrocytes modulates autism spectrum disorder-like behaviors in mice
title_full_unstemmed	Impaired calcium signaling in astrocytes modulates autism spectrum disorder-like behaviors in mice
title_sort	impaired calcium signaling in astrocytes modulates autism spectrum disorder-like behaviors in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8bdbbf173fa34c22af105a449a7b98e1
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Impaired calcium signaling in astrocytes modulates autism spectrum disorder-like behaviors in mice

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