Different levels of blood pressure, different benefit from dual antiplatelet therapy in minor stroke or TIA patients

Abstract The study aimed to evaluate whether the benefits of dual antiplatelet therapy would be influenced by blood pressure (BP) levels, among acute minor stroke or transient ischemic attack (TIA). In CHANCE (Clopidogrel in High-Risk Patients with Acute Nondisabling cerebrovascular Events) trail, P...

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Autores principales:	Jie Xu, Yongli Tao, Hao Li, Hongqiu Gu, Xuewei Xie, Xia Meng, Yuming Xu, Yilong Wang, Yongjun Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8be06250f6b24b92af20737238db3138
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spelling	oai:doaj.org-article:8be06250f6b24b92af20737238db31382021-12-02T11:52:19ZDifferent levels of blood pressure, different benefit from dual antiplatelet therapy in minor stroke or TIA patients10.1038/s41598-017-04169-82045-2322https://doaj.org/article/8be06250f6b24b92af20737238db31382017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04169-8https://doaj.org/toc/2045-2322Abstract The study aimed to evaluate whether the benefits of dual antiplatelet therapy would be influenced by blood pressure (BP) levels, among acute minor stroke or transient ischemic attack (TIA). In CHANCE (Clopidogrel in High-Risk Patients with Acute Nondisabling cerebrovascular Events) trail, Patients were stratified by systolic BP (SBP) and diastolic BP (DBP) level measured on admission, respectively, using the supine position BP within 24 hours after symptoms onset. The primary efficacy outcome was stroke recurrence, bleeding was the safety outcome. Patients with SBP ≥ 140 mmHg, dual antiplatelet treatment could reduce the risk of stroke recurrence significantly (HR 0.654, 95% CI 0.529–0.793, p < 0.001) than mono antiplatelet therapy. And patients with DBP ≥ 90 mmHg, clopidogrel-aspirin significantly reduced the risk of recurrent stroke (HR 0.588, 95% CI 0.463–0.746, p < 0.001), compared with aspirin alone. However, in patients with SBP < 140 mmHg or DBP < 90 mmHg, no significant difference was observed between clopidogrel plus aspirin and aspirin alone. there was no difference in bleeding episodes by treatment assignment across categories of SBP or DBP. Patients with SBP ≥ 140 mmHg or DBP ≥ 90 mmHg after minor stroke or TIA got more benefits from dual antiplatelet therapy. Bleeding risk from dual antiplatelet treatment did not increase among patients with higher BP level on admission.Jie XuYongli TaoHao LiHongqiu GuXuewei XieXia MengYuming XuYilong WangYongjun WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-6 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jie Xu Yongli Tao Hao Li Hongqiu Gu Xuewei Xie Xia Meng Yuming Xu Yilong Wang Yongjun Wang Different levels of blood pressure, different benefit from dual antiplatelet therapy in minor stroke or TIA patients
description	Abstract The study aimed to evaluate whether the benefits of dual antiplatelet therapy would be influenced by blood pressure (BP) levels, among acute minor stroke or transient ischemic attack (TIA). In CHANCE (Clopidogrel in High-Risk Patients with Acute Nondisabling cerebrovascular Events) trail, Patients were stratified by systolic BP (SBP) and diastolic BP (DBP) level measured on admission, respectively, using the supine position BP within 24 hours after symptoms onset. The primary efficacy outcome was stroke recurrence, bleeding was the safety outcome. Patients with SBP ≥ 140 mmHg, dual antiplatelet treatment could reduce the risk of stroke recurrence significantly (HR 0.654, 95% CI 0.529–0.793, p < 0.001) than mono antiplatelet therapy. And patients with DBP ≥ 90 mmHg, clopidogrel-aspirin significantly reduced the risk of recurrent stroke (HR 0.588, 95% CI 0.463–0.746, p < 0.001), compared with aspirin alone. However, in patients with SBP < 140 mmHg or DBP < 90 mmHg, no significant difference was observed between clopidogrel plus aspirin and aspirin alone. there was no difference in bleeding episodes by treatment assignment across categories of SBP or DBP. Patients with SBP ≥ 140 mmHg or DBP ≥ 90 mmHg after minor stroke or TIA got more benefits from dual antiplatelet therapy. Bleeding risk from dual antiplatelet treatment did not increase among patients with higher BP level on admission.
format	article
author	Jie Xu Yongli Tao Hao Li Hongqiu Gu Xuewei Xie Xia Meng Yuming Xu Yilong Wang Yongjun Wang
author_facet	Jie Xu Yongli Tao Hao Li Hongqiu Gu Xuewei Xie Xia Meng Yuming Xu Yilong Wang Yongjun Wang
author_sort	Jie Xu
title	Different levels of blood pressure, different benefit from dual antiplatelet therapy in minor stroke or TIA patients
title_short	Different levels of blood pressure, different benefit from dual antiplatelet therapy in minor stroke or TIA patients
title_full	Different levels of blood pressure, different benefit from dual antiplatelet therapy in minor stroke or TIA patients
title_fullStr	Different levels of blood pressure, different benefit from dual antiplatelet therapy in minor stroke or TIA patients
title_full_unstemmed	Different levels of blood pressure, different benefit from dual antiplatelet therapy in minor stroke or TIA patients
title_sort	different levels of blood pressure, different benefit from dual antiplatelet therapy in minor stroke or tia patients
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8be06250f6b24b92af20737238db3138
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Different levels of blood pressure, different benefit from dual antiplatelet therapy in minor stroke or TIA patients

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