Marcksl1 modulates endothelial cell mechanoresponse to haemodynamic forces to control blood vessel shape and size

During lumen formation in blood vessels, endothelial cells become exposed to hemodynamic forces that induce membrane blebbing and changes in cell shape. Here, the authors show endothelial cells develop an actin-based protective mechanism in the cell cortex that prevents excessive blebbing to control...

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Autores principales:	Igor Kondrychyn, Douglas J. Kelly, Núria Taberner Carretero, Akane Nomori, Kagayaki Kato, Jeronica Chong, Hiroyuki Nakajima, Satoru Okuda, Naoki Mochizuki, Li-Kun Phng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8be070b1e19849db983d903f0665e3ed
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spelling	oai:doaj.org-article:8be070b1e19849db983d903f0665e3ed2021-12-02T16:49:44ZMarcksl1 modulates endothelial cell mechanoresponse to haemodynamic forces to control blood vessel shape and size10.1038/s41467-020-19308-52041-1723https://doaj.org/article/8be070b1e19849db983d903f0665e3ed2020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19308-5https://doaj.org/toc/2041-1723During lumen formation in blood vessels, endothelial cells become exposed to hemodynamic forces that induce membrane blebbing and changes in cell shape. Here, the authors show endothelial cells develop an actin-based protective mechanism in the cell cortex that prevents excessive blebbing to control cell shape and vessel diameter.Igor KondrychynDouglas J. KellyNúria Taberner CarreteroAkane NomoriKagayaki KatoJeronica ChongHiroyuki NakajimaSatoru OkudaNaoki MochizukiLi-Kun PhngNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Igor Kondrychyn Douglas J. Kelly Núria Taberner Carretero Akane Nomori Kagayaki Kato Jeronica Chong Hiroyuki Nakajima Satoru Okuda Naoki Mochizuki Li-Kun Phng Marcksl1 modulates endothelial cell mechanoresponse to haemodynamic forces to control blood vessel shape and size
description	During lumen formation in blood vessels, endothelial cells become exposed to hemodynamic forces that induce membrane blebbing and changes in cell shape. Here, the authors show endothelial cells develop an actin-based protective mechanism in the cell cortex that prevents excessive blebbing to control cell shape and vessel diameter.
format	article
author	Igor Kondrychyn Douglas J. Kelly Núria Taberner Carretero Akane Nomori Kagayaki Kato Jeronica Chong Hiroyuki Nakajima Satoru Okuda Naoki Mochizuki Li-Kun Phng
author_facet	Igor Kondrychyn Douglas J. Kelly Núria Taberner Carretero Akane Nomori Kagayaki Kato Jeronica Chong Hiroyuki Nakajima Satoru Okuda Naoki Mochizuki Li-Kun Phng
author_sort	Igor Kondrychyn
title	Marcksl1 modulates endothelial cell mechanoresponse to haemodynamic forces to control blood vessel shape and size
title_short	Marcksl1 modulates endothelial cell mechanoresponse to haemodynamic forces to control blood vessel shape and size
title_full	Marcksl1 modulates endothelial cell mechanoresponse to haemodynamic forces to control blood vessel shape and size
title_fullStr	Marcksl1 modulates endothelial cell mechanoresponse to haemodynamic forces to control blood vessel shape and size
title_full_unstemmed	Marcksl1 modulates endothelial cell mechanoresponse to haemodynamic forces to control blood vessel shape and size
title_sort	marcksl1 modulates endothelial cell mechanoresponse to haemodynamic forces to control blood vessel shape and size
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/8be070b1e19849db983d903f0665e3ed
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Marcksl1 modulates endothelial cell mechanoresponse to haemodynamic forces to control blood vessel shape and size

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