Quantitative proteomics and single-nucleus transcriptomics of the sinus node elucidates the foundation of cardiac pacemaking

The sinus node generates rhythmic heartbeat but the molecular basis of pacemaking is still under debate. Here, the authors combine quantitative proteomics and single-nucleus transcriptomics to characterize the molecular composition of the sinus node and provide insights into the underpinnings of pac...

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Autores principales:	Nora Linscheid, Sunil Jit R. J. Logantha, Pi Camilla Poulsen, Shanzhuo Zhang, Maren Schrölkamp, Kristoffer Lihme Egerod, Jonatan James Thompson, Ashraf Kitmitto, Gina Galli, Martin J. Humphries, Henggui Zhang, Tune H. Pers, Jesper Velgaard Olsen, Mark Boyett, Alicia Lundby
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8be1ba1976464a228f6bde3e4a31e04c
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spelling	oai:doaj.org-article:8be1ba1976464a228f6bde3e4a31e04c2021-12-02T14:39:20ZQuantitative proteomics and single-nucleus transcriptomics of the sinus node elucidates the foundation of cardiac pacemaking10.1038/s41467-019-10709-92041-1723https://doaj.org/article/8be1ba1976464a228f6bde3e4a31e04c2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10709-9https://doaj.org/toc/2041-1723The sinus node generates rhythmic heartbeat but the molecular basis of pacemaking is still under debate. Here, the authors combine quantitative proteomics and single-nucleus transcriptomics to characterize the molecular composition of the sinus node and provide insights into the underpinnings of pacemaking.Nora LinscheidSunil Jit R. J. LoganthaPi Camilla PoulsenShanzhuo ZhangMaren SchrölkampKristoffer Lihme EgerodJonatan James ThompsonAshraf KitmittoGina GalliMartin J. HumphriesHenggui ZhangTune H. PersJesper Velgaard OlsenMark BoyettAlicia LundbyNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-19 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nora Linscheid Sunil Jit R. J. Logantha Pi Camilla Poulsen Shanzhuo Zhang Maren Schrölkamp Kristoffer Lihme Egerod Jonatan James Thompson Ashraf Kitmitto Gina Galli Martin J. Humphries Henggui Zhang Tune H. Pers Jesper Velgaard Olsen Mark Boyett Alicia Lundby Quantitative proteomics and single-nucleus transcriptomics of the sinus node elucidates the foundation of cardiac pacemaking
description	The sinus node generates rhythmic heartbeat but the molecular basis of pacemaking is still under debate. Here, the authors combine quantitative proteomics and single-nucleus transcriptomics to characterize the molecular composition of the sinus node and provide insights into the underpinnings of pacemaking.
format	article
author	Nora Linscheid Sunil Jit R. J. Logantha Pi Camilla Poulsen Shanzhuo Zhang Maren Schrölkamp Kristoffer Lihme Egerod Jonatan James Thompson Ashraf Kitmitto Gina Galli Martin J. Humphries Henggui Zhang Tune H. Pers Jesper Velgaard Olsen Mark Boyett Alicia Lundby
author_facet	Nora Linscheid Sunil Jit R. J. Logantha Pi Camilla Poulsen Shanzhuo Zhang Maren Schrölkamp Kristoffer Lihme Egerod Jonatan James Thompson Ashraf Kitmitto Gina Galli Martin J. Humphries Henggui Zhang Tune H. Pers Jesper Velgaard Olsen Mark Boyett Alicia Lundby
author_sort	Nora Linscheid
title	Quantitative proteomics and single-nucleus transcriptomics of the sinus node elucidates the foundation of cardiac pacemaking
title_short	Quantitative proteomics and single-nucleus transcriptomics of the sinus node elucidates the foundation of cardiac pacemaking
title_full	Quantitative proteomics and single-nucleus transcriptomics of the sinus node elucidates the foundation of cardiac pacemaking
title_fullStr	Quantitative proteomics and single-nucleus transcriptomics of the sinus node elucidates the foundation of cardiac pacemaking
title_full_unstemmed	Quantitative proteomics and single-nucleus transcriptomics of the sinus node elucidates the foundation of cardiac pacemaking
title_sort	quantitative proteomics and single-nucleus transcriptomics of the sinus node elucidates the foundation of cardiac pacemaking
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/8be1ba1976464a228f6bde3e4a31e04c
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Quantitative proteomics and single-nucleus transcriptomics of the sinus node elucidates the foundation of cardiac pacemaking

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