Interactive Effects of Enalapril Administration and Novel HIIT Wheel-Bed Training in Aged Rats

Introduction: Growing research suggests that aerobic high-intensity interval training (HIIT) improves cardiovascular function and physical performance compared with moderate intensity continuous training (MICT). However relatively few animal models of HIIT are available to inform about the benefits...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Youfeng Yang, Anisha Banerjee, Yi Sun, Christy S. Carter, Thomas W. Buford
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	aging forced exercise renin-angiotensin system multi-modal intervention strength Other systems of medicine RZ201-999 Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/8be57fddad5b43af9e2aed4769f7a1f2
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8be57fddad5b43af9e2aed4769f7a1f2
record_format	dspace
spelling	oai:doaj.org-article:8be57fddad5b43af9e2aed4769f7a1f22021-11-08T05:06:42ZInteractive Effects of Enalapril Administration and Novel HIIT Wheel-Bed Training in Aged Rats2673-686110.3389/fresc.2021.764686https://doaj.org/article/8be57fddad5b43af9e2aed4769f7a1f22021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fresc.2021.764686/fullhttps://doaj.org/toc/2673-6861Introduction: Growing research suggests that aerobic high-intensity interval training (HIIT) improves cardiovascular function and physical performance compared with moderate intensity continuous training (MICT). However relatively few animal models of HIIT are available to inform about the benefits of this exercise—particularly among older animals. In addition, there is little evidence for how HIIT training interacts with adjuvant pharmacological therapies known to enhance the impact of MCIT in older individuals such as Angiotensin Converting Enzyme (ACE) Inhibitors.Purpose: The aim of the present study was to establish a HIIT protocol in aged rats based on forced running wheel-bed, and to subsequently (1) establish the feasibility of the HIIT protocol in a proof-of-concept study evaluating interactions between HIIT and (2) the result of combining HIIT + ACE inhibitor treatment using the ACE inhibitor enalapril.Methods: Two groups of rats were used in this study. The feasibility of using wheel-bed for HIIT training was tested in group one (15- and 30-month-old male rats). In the second group, 37 24-month-old Fisher 344 x Brown Norway male rats were randomly divided into four subgroups: control, enalapril, HIIT training group, and HIIT training combined with enalapril administration. The training and administration lasted for 4 weeks. After the intervention, locomotor activity, exercise tolerance, and grip strength were tested.Results: Our feasibility study suggested that middle-aged and aged rats were able to successfully complete the HIIT training. In our intervention study, HIIT training alone, regardless of adjuvant enalapril intervention, did raise treadmill exercise tolerance vs. the sedentary condition. Measures of healthspan were not negatively impacted by HIIT training.Conclusion: The novel HIIT protocol based on forced running wheel-bed was successfully employed in aged rats. We conclude that future studies should compare the results and of multi-modal intervention strategies which include both HIIT and MICT in combination with adjuvant therapies such as enalapril to improve exercise tolerance and other global indices of healthspan.Youfeng YangYoufeng YangYoufeng YangAnisha BanerjeeAnisha BanerjeeAnisha BanerjeeYi SunYi SunYi SunChristy S. CarterChristy S. CarterChristy S. CarterThomas W. BufordThomas W. BufordThomas W. BufordThomas W. BufordFrontiers Media S.A.articleagingforced exerciserenin-angiotensin systemmulti-modal interventionstrengthOther systems of medicineRZ201-999Medical technologyR855-855.5ENFrontiers in Rehabilitation Sciences, Vol 2 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	aging forced exercise renin-angiotensin system multi-modal intervention strength Other systems of medicine RZ201-999 Medical technology R855-855.5
spellingShingle	aging forced exercise renin-angiotensin system multi-modal intervention strength Other systems of medicine RZ201-999 Medical technology R855-855.5 Youfeng Yang Youfeng Yang Youfeng Yang Anisha Banerjee Anisha Banerjee Anisha Banerjee Yi Sun Yi Sun Yi Sun Christy S. Carter Christy S. Carter Christy S. Carter Thomas W. Buford Thomas W. Buford Thomas W. Buford Thomas W. Buford Interactive Effects of Enalapril Administration and Novel HIIT Wheel-Bed Training in Aged Rats
description	Introduction: Growing research suggests that aerobic high-intensity interval training (HIIT) improves cardiovascular function and physical performance compared with moderate intensity continuous training (MICT). However relatively few animal models of HIIT are available to inform about the benefits of this exercise—particularly among older animals. In addition, there is little evidence for how HIIT training interacts with adjuvant pharmacological therapies known to enhance the impact of MCIT in older individuals such as Angiotensin Converting Enzyme (ACE) Inhibitors.Purpose: The aim of the present study was to establish a HIIT protocol in aged rats based on forced running wheel-bed, and to subsequently (1) establish the feasibility of the HIIT protocol in a proof-of-concept study evaluating interactions between HIIT and (2) the result of combining HIIT + ACE inhibitor treatment using the ACE inhibitor enalapril.Methods: Two groups of rats were used in this study. The feasibility of using wheel-bed for HIIT training was tested in group one (15- and 30-month-old male rats). In the second group, 37 24-month-old Fisher 344 x Brown Norway male rats were randomly divided into four subgroups: control, enalapril, HIIT training group, and HIIT training combined with enalapril administration. The training and administration lasted for 4 weeks. After the intervention, locomotor activity, exercise tolerance, and grip strength were tested.Results: Our feasibility study suggested that middle-aged and aged rats were able to successfully complete the HIIT training. In our intervention study, HIIT training alone, regardless of adjuvant enalapril intervention, did raise treadmill exercise tolerance vs. the sedentary condition. Measures of healthspan were not negatively impacted by HIIT training.Conclusion: The novel HIIT protocol based on forced running wheel-bed was successfully employed in aged rats. We conclude that future studies should compare the results and of multi-modal intervention strategies which include both HIIT and MICT in combination with adjuvant therapies such as enalapril to improve exercise tolerance and other global indices of healthspan.
format	article
author	Youfeng Yang Youfeng Yang Youfeng Yang Anisha Banerjee Anisha Banerjee Anisha Banerjee Yi Sun Yi Sun Yi Sun Christy S. Carter Christy S. Carter Christy S. Carter Thomas W. Buford Thomas W. Buford Thomas W. Buford Thomas W. Buford
author_facet	Youfeng Yang Youfeng Yang Youfeng Yang Anisha Banerjee Anisha Banerjee Anisha Banerjee Yi Sun Yi Sun Yi Sun Christy S. Carter Christy S. Carter Christy S. Carter Thomas W. Buford Thomas W. Buford Thomas W. Buford Thomas W. Buford
author_sort	Youfeng Yang
title	Interactive Effects of Enalapril Administration and Novel HIIT Wheel-Bed Training in Aged Rats
title_short	Interactive Effects of Enalapril Administration and Novel HIIT Wheel-Bed Training in Aged Rats
title_full	Interactive Effects of Enalapril Administration and Novel HIIT Wheel-Bed Training in Aged Rats
title_fullStr	Interactive Effects of Enalapril Administration and Novel HIIT Wheel-Bed Training in Aged Rats
title_full_unstemmed	Interactive Effects of Enalapril Administration and Novel HIIT Wheel-Bed Training in Aged Rats
title_sort	interactive effects of enalapril administration and novel hiit wheel-bed training in aged rats
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/8be57fddad5b43af9e2aed4769f7a1f2
work_keys_str_mv	AT youfengyang interactiveeffectsofenalapriladministrationandnovelhiitwheelbedtraininginagedrats AT youfengyang interactiveeffectsofenalapriladministrationandnovelhiitwheelbedtraininginagedrats AT youfengyang interactiveeffectsofenalapriladministrationandnovelhiitwheelbedtraininginagedrats AT anishabanerjee interactiveeffectsofenalapriladministrationandnovelhiitwheelbedtraininginagedrats AT anishabanerjee interactiveeffectsofenalapriladministrationandnovelhiitwheelbedtraininginagedrats AT anishabanerjee interactiveeffectsofenalapriladministrationandnovelhiitwheelbedtraininginagedrats AT yisun interactiveeffectsofenalapriladministrationandnovelhiitwheelbedtraininginagedrats AT yisun interactiveeffectsofenalapriladministrationandnovelhiitwheelbedtraininginagedrats AT yisun interactiveeffectsofenalapriladministrationandnovelhiitwheelbedtraininginagedrats AT christyscarter interactiveeffectsofenalapriladministrationandnovelhiitwheelbedtraininginagedrats AT christyscarter interactiveeffectsofenalapriladministrationandnovelhiitwheelbedtraininginagedrats AT christyscarter interactiveeffectsofenalapriladministrationandnovelhiitwheelbedtraininginagedrats AT thomaswbuford interactiveeffectsofenalapriladministrationandnovelhiitwheelbedtraininginagedrats AT thomaswbuford interactiveeffectsofenalapriladministrationandnovelhiitwheelbedtraininginagedrats AT thomaswbuford interactiveeffectsofenalapriladministrationandnovelhiitwheelbedtraininginagedrats AT thomaswbuford interactiveeffectsofenalapriladministrationandnovelhiitwheelbedtraininginagedrats
_version_	1718443019501305856

Interactive Effects of Enalapril Administration and Novel HIIT Wheel-Bed Training in Aged Rats

Ejemplares similares