Optimization of Photooxygenation of Dihydroartemisinic Acid in a Continuous Micro-reactor utilizing Physically Immobilized Methylene Blue on Polystyrene Micro-particles

Extensive studies reported upon the application of microfluidic devices for photooxygenation reactions. Only a few researches, however, have studied the optimization of experimentally controllable parameters towards achieving the best reaction conversion. Accordingly, in the current study, the optim...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Mohsen Tamtaji, Mohsmmad Kazemeini
Formato:	article
Lenguaje:	EN
Publicado:	AIDIC Servizi S.r.l. 2021
Materias:	Chemical engineering TP155-156 Computer engineering. Computer hardware TK7885-7895
Acceso en línea:	https://doaj.org/article/8beb5485bc1b4b609feaaa7d52ad0f26
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8beb5485bc1b4b609feaaa7d52ad0f26
record_format	dspace
spelling	oai:doaj.org-article:8beb5485bc1b4b609feaaa7d52ad0f262021-11-15T21:46:49ZOptimization of Photooxygenation of Dihydroartemisinic Acid in a Continuous Micro-reactor utilizing Physically Immobilized Methylene Blue on Polystyrene Micro-particles10.3303/CET21882212283-9216https://doaj.org/article/8beb5485bc1b4b609feaaa7d52ad0f262021-11-01T00:00:00Zhttps://www.cetjournal.it/index.php/cet/article/view/12014https://doaj.org/toc/2283-9216Extensive studies reported upon the application of microfluidic devices for photooxygenation reactions. Only a few researches, however, have studied the optimization of experimentally controllable parameters towards achieving the best reaction conversion. Accordingly, in the current study, the optimum values of operating parameters towards achieving the highest dihydroartemisinic acid (DHAA) conversion were determined through the response surface methodology (RSM) technique. In order to do that, first, heterogenized micro-photosensitizers were synthesized during a super facile procedure not requiring any chemical reaction or modifications. Then, these micro-photosensitizers were utilized to perform continuous photooxygenation of the DHAA by means of a glass micro-reactor at room temperature and atmospheric pressure. Finally, the impacts of experimental parameters such as the flow ratios of solution to oxygen as well as DHAA and micro-photosensitizers’ concentrations upon the DHAA conversions were examined by using Design of Experiments (DOE) software in order to optimize and statistically model the DHAA conversion. The optimum value for this conversion was predicted by the RSM technique to be 70 % which was in a very good agreement with that of the experimental value of 69 % obtained in this study. The optimal values for the flow rates ratio, DHAA initial concentration, and micro-photosensitizer’s concentration were obtained to be 0.5, 0.5 mg/ml, as well as 1.5 mg/ml, respectively.Mohsen TamtajiMohsmmad KazemeiniAIDIC Servizi S.r.l.articleChemical engineeringTP155-156Computer engineering. Computer hardwareTK7885-7895ENChemical Engineering Transactions, Vol 88 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chemical engineering TP155-156 Computer engineering. Computer hardware TK7885-7895
spellingShingle	Chemical engineering TP155-156 Computer engineering. Computer hardware TK7885-7895 Mohsen Tamtaji Mohsmmad Kazemeini Optimization of Photooxygenation of Dihydroartemisinic Acid in a Continuous Micro-reactor utilizing Physically Immobilized Methylene Blue on Polystyrene Micro-particles
description	Extensive studies reported upon the application of microfluidic devices for photooxygenation reactions. Only a few researches, however, have studied the optimization of experimentally controllable parameters towards achieving the best reaction conversion. Accordingly, in the current study, the optimum values of operating parameters towards achieving the highest dihydroartemisinic acid (DHAA) conversion were determined through the response surface methodology (RSM) technique. In order to do that, first, heterogenized micro-photosensitizers were synthesized during a super facile procedure not requiring any chemical reaction or modifications. Then, these micro-photosensitizers were utilized to perform continuous photooxygenation of the DHAA by means of a glass micro-reactor at room temperature and atmospheric pressure. Finally, the impacts of experimental parameters such as the flow ratios of solution to oxygen as well as DHAA and micro-photosensitizers’ concentrations upon the DHAA conversions were examined by using Design of Experiments (DOE) software in order to optimize and statistically model the DHAA conversion. The optimum value for this conversion was predicted by the RSM technique to be 70 % which was in a very good agreement with that of the experimental value of 69 % obtained in this study. The optimal values for the flow rates ratio, DHAA initial concentration, and micro-photosensitizer’s concentration were obtained to be 0.5, 0.5 mg/ml, as well as 1.5 mg/ml, respectively.
format	article
author	Mohsen Tamtaji Mohsmmad Kazemeini
author_facet	Mohsen Tamtaji Mohsmmad Kazemeini
author_sort	Mohsen Tamtaji
title	Optimization of Photooxygenation of Dihydroartemisinic Acid in a Continuous Micro-reactor utilizing Physically Immobilized Methylene Blue on Polystyrene Micro-particles
title_short	Optimization of Photooxygenation of Dihydroartemisinic Acid in a Continuous Micro-reactor utilizing Physically Immobilized Methylene Blue on Polystyrene Micro-particles
title_full	Optimization of Photooxygenation of Dihydroartemisinic Acid in a Continuous Micro-reactor utilizing Physically Immobilized Methylene Blue on Polystyrene Micro-particles
title_fullStr	Optimization of Photooxygenation of Dihydroartemisinic Acid in a Continuous Micro-reactor utilizing Physically Immobilized Methylene Blue on Polystyrene Micro-particles
title_full_unstemmed	Optimization of Photooxygenation of Dihydroartemisinic Acid in a Continuous Micro-reactor utilizing Physically Immobilized Methylene Blue on Polystyrene Micro-particles
title_sort	optimization of photooxygenation of dihydroartemisinic acid in a continuous micro-reactor utilizing physically immobilized methylene blue on polystyrene micro-particles
publisher	AIDIC Servizi S.r.l.
publishDate	2021
url	https://doaj.org/article/8beb5485bc1b4b609feaaa7d52ad0f26
work_keys_str_mv	AT mohsentamtaji optimizationofphotooxygenationofdihydroartemisinicacidinacontinuousmicroreactorutilizingphysicallyimmobilizedmethyleneblueonpolystyrenemicroparticles AT mohsmmadkazemeini optimizationofphotooxygenationofdihydroartemisinicacidinacontinuousmicroreactorutilizingphysicallyimmobilizedmethyleneblueonpolystyrenemicroparticles
_version_	1718426855098286080

Optimization of Photooxygenation of Dihydroartemisinic Acid in a Continuous Micro-reactor utilizing Physically Immobilized Methylene Blue on Polystyrene Micro-particles

Ejemplares similares